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Although Parkinson's disease (PD) is characterized by dyskinesia, it is associated with distinct non-motor features, including gastrointestinal (GI) dysfunction such as constipation, dysphagia, hypersalivation, delayed gastric emptying, and regurgitation flow
Although Parkinson's disease (PD) is characterized by dyskinesia, it is associated with distinct non-motor features, including gastrointestinal (GI) dysfunction such as constipation, dysphagia, hypersalivation, delayed gastric emptying, and regurgitation flow
Figure 1: Paper title map
Figure 1: Paper title mapResearch efforts on the gut-brain axis have greatly increased, and there is growing evidence that gut dysfunction may play a role in the early pathogenesis of PD; however, its link to disease progression has been underrepresented attention
Research efforts on the gut-brain axis have greatly increased, and there is growing evidence that gut dysfunction may play a role in the early pathogenesis of PD; however, its link to disease progression has been underrepresented attention
Figure 2: Constipation affects clinical outcomes
Figure 2: Constipation affects clinical outcomesWith this, M.
With this, M.
Constipation is assessed by the MDS-UPDRS Constipation Item or a similar categorical scale
The primary PD outcomes of interest were dementia, postural instability, and death
PD patients were stratified according to the severity of constipation at diagnosis
After adjusting for relevant confounders, Cox regression analysis confirmed a significant association between constipation severity and dementia progression, but not postural instability or death
Thus, early constipation may herald the accelerated development of neurodegenerative disease
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