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JAMA Sub-Journal: Differences in Cortical PET Imaging Patterns in Preclinical Alzheimer's Patients
Time of Update: 2022-05-08
preventionTo evaluate the prevalence of cortical tau positron emission tomography (PET) heterogeneity with elevated beta-amyloid (A+) in a large clinically accessible cohort of older adults, experts from Stanford University conducted a A cross-sectional study examining pre-randomization tau PET, amyloid PET, structural magnetic resonance imaging, demographics and cognition from the Anti-Amyloid Therapy (A4) study in asymptomatic AD from April 2014 to December 2017 data .
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Stroke: The effect of intensive blood pressure reduction on the risk of stroke in patients with mild cognitive impairment
Time of Update: 2022-05-08
Patients with mild cognitive impairment may be at higher risk for stroke, but the impact of intensive blood pressure control on this effect is unclear .
Effect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairment.
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Alzheimer&Dementia: Preventing Dementia Starts as a Baby - Diet and Exercise Can Affect Brain Neurogenesis Years Before Dementia
Time of Update: 2022-05-08
Several clinical studies have documented the protective effect of increased exercise on CD/dementia and revealed how greater adherence to the Mediterranean diet slows CD and reduces dementia risk .
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Cell ushered in a qualitative leap!
Time of Update: 2022-04-30
A major goal of contemporary neuroscience at iNature is to identify the neural populations underlying complex mammalian brain function, a goal made possible by new techniques for large-scale neural recordings during behavior, optical imaging being one of these techniques .
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The latest research from Yale University uncovers the molecular mechanism of the blood-brain barrier and briefly opens the blood-brain barrier
Time of Update: 2022-04-30
The receptor Unc5B of vascular endothelial cells maintains the integrity of the blood-brain barrier by regulating the Wnt signaling pathway .
. Collectively, this study demonstrates that the vascular endothelial cell receptor Unc5B maintains the integrity of the blood-brain barrier by regulating the Wnt signaling pathway .
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NBE Hong Guosong/Pu Kanyi Collaborate to Regulate Neural Activity Using Near-Infrared Light Penetrating the Brain
Time of Update: 2022-04-30
Compared with visible light used in traditional optogenetics, near-infrared light penetrates deeper in strong scattering media such as biological tissue, and is therefore more suitable as an energy transfer medium in non-invasive neuromodulation techniques .
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Cell: The latest version 3.0!
Time of Update: 2022-04-30
On the other hand, the technique of imaging calcium ions in free-motion state using single-photon microscopic microscopes has developed rapidly and has been widely used in neuroscience research .
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Science Tuberous sclerosis human brain organoids: expansion of interneuronal progenitors drives tumor and cortical nodule development
Time of Update: 2022-04-30
They completed the TSC human brain organoid model of tuberous sclerosis complex , by scRNA-seq and histological validation, identified a specific interneuron progenitor population, caudal late interneuron progenitors (caudal late interneuron progenitors) originating from the caudal ganglionic eminence (CGE) in mid-gestation cells, CLIP), which are hyperproliferative in TSC and can cause brain tumors and cortical nodules .
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Study finds thalamo-cortical mechanism of nostalgic analgesia
Time of Update: 2022-04-30
Studies have shown that the thalamus, a key brain region that regulates pain, is also involved in nostalgia-related analgesia (Figure E) .
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Glia︱Yuan Jianqiang's group reveals a new mechanism for regulating the proliferation of oligodendrocyte precursor cells: c-Abl phosphorylates Olig2
Time of Update: 2022-04-30
The study found that specific knockout of c-Abl resulted in decreased oligodendrocyte lineage gene expression, insufficient OPCs proliferation, and blocked myelin formation; in a bicyclohexanone oxalyl dihydrazone (CPZ)-induced demyelination model, specific Remyelination was delayed in c-Abl knockout mice .
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Dizziness, unsteady walking for 1 month, double vision for 8 days, is it a cerebral infarction?
Time of Update: 2022-04-29
The patient went to the emergency department of a local hospital for treatment, and underwent head MRI (unenhanced scan + DWI), and found a right cerebellar lesion (DWI high signal).
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Nature sub-issue: Professor Han Minghu reveals differential neural circuits that regulate anxiety and depression behaviors
Time of Update: 2022-04-29
Further experiments found that light activation of the VTA → BLA circuit could alleviate anxiety-like behaviors (increase the dwell time of the open arms) in AD mice and A mice, but could not alleviate behavioral disorders such as social impairment and anhedonia in AD mice .
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Bravely breaking into the restricted area, how to overcome this case of thalamic space occupation?
Time of Update: 2022-04-29
Before surgery, the patient's diagnosis was considered to be a right thalamic tumor, a possible glioma, and a meningioma .
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JCI Xiamen University multi-unit cooperation, Wang Xin/Xu Huaxi/Song Weihong discovered potential targets for the treatment of Alzheimer's disease
Time of Update: 2022-04-29
Furthermore, overexpression of chromosome 21-encoded USP25 significantly increased amyloid deposition, and USP25 deficiency ameliorated amyloid pathology in 5 × FAD mice by regulating APP processing and Aβ production .
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Professor Lou Wenhui talks about perioperative treatment strategies for pancreatic neuroendocrine tumors, and individualized diagnosis and treatment can break the situation!
Time of Update: 2022-04-29
In order to clarify the surgical intervention methods for NEN patients and the individualized treatment and follow-up strategies for NEN patients, the Medical Tumor Channel invited Professor Lou Wenhui from the Pancreatic Surgery Department of Zhongshan Hospital Affiliated to Fudan University to conduct a comprehensive analysis and discussion on the above issues .
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Study reveals neural mechanism of stress-induced anxiety and metabolic abnormalities
Time of Update: 2022-04-29
The research results exerts dual control of anxiety-like behavior and energy expenditure, revealing that the cluster discharge of ventromedial hypothalamus (VMH) neurons in chronic stress stress regulates anxiety and energy metabolism, while The calcium channel Cav3.
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NSMB Ye Keqiang/Zhang Zhentao collaborated to reveal the mechanism of Tau protein aggregation and lesion dissemination in the locus coeruleus region
Time of Update: 2022-04-29
The research team found that the norepinephrine metabolite DOPEGAL in the locus coeruleus covalently modifies the K353 site of Tau protein, promoting Tau aggregation and disease dissemination .
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Using allogeneic stem cells to fight Parkinson's, clinical trials are successfully advanced
Time of Update: 2022-04-29
March 27, 2022 / eMedClub News / -- On March 24, 2022, IMAC Holdings announced that its allogeneic umbilical cord-derived mesenchymal stem cells for the treatment of Parkinson's disease-induced bradykinesia have initiated Phase 1 The third and final cohort of the clinical trial .
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Science︱ Mouse REM sleep is regulated by dopamine signaling in the basolateral amygdala
Time of Update: 2022-04-29
Next, we demonstrated that optogenetic inhibition of Drd2 neurons following implantation of optical fibers in the BLA of vLWO-expressing Drd2-Cre mice induced a transition from NREM to REM sleep (Fig.
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Progress in the analysis of single-cell transcriptome and developmental trajectories of early mouse embryonic inner ear ganglion cells
Time of Update: 2022-04-29
Although mature inner ear vestibular ganglia and spiral ganglia have different functions, they both originate from early embryonic otic capsule neuroblasts, also known as cochlear vestibular ganglion precursor cells (CVGs) .
