-
Using allogeneic stem cells to fight Parkinson's, clinical trials are successfully advanced
Time of Update: 2022-04-29
March 27, 2022 / eMedClub News / -- On March 24, 2022, IMAC Holdings announced that its allogeneic umbilical cord-derived mesenchymal stem cells for the treatment of Parkinson's disease-induced bradykinesia have initiated Phase 1 The third and final cohort of the clinical trial .
-
Progress in the analysis of single-cell transcriptome and developmental trajectories of early mouse embryonic inner ear ganglion cells
Time of Update: 2022-04-29
Although mature inner ear vestibular ganglia and spiral ganglia have different functions, they both originate from early embryonic otic capsule neuroblasts, also known as cochlear vestibular ganglion precursor cells (CVGs) .
-
JCI Xiamen University multi-unit cooperation, Wang Xin/Xu Huaxi/Song Weihong discovered potential targets for the treatment of Alzheimer's disease
Time of Update: 2022-04-29
Furthermore, overexpression of chromosome 21-encoded USP25 significantly increased amyloid deposition, and USP25 deficiency ameliorated amyloid pathology in 5 × FAD mice by regulating APP processing and Aβ production .
-
Nature : How do bacteria invade the brain?
Time of Update: 2022-04-29
On March 16, 2022, the research team of Marc Lecuit of the University of Paris established a Listeria infection model and found that Listeria can enter the brain parenchyma through intercellular diffusion through peripheral monocytes, which inhibits Fas apoptosis through InlB.
-
Nat Neurosci︱ Down-regulation of neuroimmunity and synapse-related pathways in the amygdala and anterior cingulate gyrus in patients with bipolar disorder
Time of Update: 2022-04-29
Hyde's team at the Johns Hopkins School of Medicine in the United States published an article entitled "Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways" in Nature Neuroscience, A series of transcriptomic analysis of RNA-seq was performed on human BD samples, and it was found that biological processes related to neuroimmunity and synaptic signaling were down-regulated in BD patients, which provided an evidence base for subsequent molecular biology studies [3] .
-
Review of Nat Neurosci︱Two-photon holographic optogenetics to detect neural coding
Time of Update: 2022-04-29
The current inability of single-photon optogenetics to reconstruct precise, cell-specific spatiotemporal activity patterns in highly dispersed brain tissue makes it challenging to specifically decode neuron-specific dynamics, for example using single-photon optogenetics Science is currently unable to address the effects of neuronal spiking frequency, neural synchrony, and neural networks on perception, cognition, and action .
-
ACTRIMS Conference Express--Interpretation of the latest research on multiple sclerosis
Time of Update: 2022-04-29
Real-world cross-sectional study: Increased EDSS score is significantly associated with increased economic burden in Chinese MS patients MS is a chronic, disabling neurological disease with clinical manifestations of multiple symptoms, including fatigue, depression, bowel/bladder function Impairment, mobility, and cognitive dysfunction that lead to limited physical activity, reduced work productivity, and increased utilization of healthcare resources in people with MS, among which cognitive impairment is a common and highly disabling disease symptom1 -3 .
-
Why do some people only sleep for 4 hours without being stupid?
Time of Update: 2022-04-29
Picture from research paper 1 For mice prone to AD, they 3 At the age of one month, the symptoms of AD will appear initially, and after 6 months, there will be obvious beta-amyloid plaques in the brain, and cognitive decline will be more obvious .
-
He was convicted of academic misconduct, lost his job and funding 3 years ago, and now he proves himself right with a Nature sub-journal
Time of Update: 2022-04-29
A successful demonstration of any BCI enabling individuals without reliable eye movement control and eye closure (CLIS) to form a complete sentence would upend these assumptions and open the door to investigations of communication and psychological processes in fully paralyzed ALS patients .
-
Science sub-journal: Stress makes people work harder under low anxiety, and flatten the state of high anxiety!
Time of Update: 2022-04-29
Injection of CRH through specific VTA brain regions can increase the target motivational behavior of low-anxiety rats and inhibit the motivational behavior of high-anxiety mice, which can simulate the effect of acute stress .
Acute stress does not increase target-motivated behaviors in low-anxiety rats after reducing CRHR1 in the VTA brain region.
-
Molecular characterization of human dorsal root ganglion nociceptors by STM using 10x Genomics Visium spatial transcriptome technology
Time of Update: 2022-04-29
Price of the University of Texas at Dallas published an article in Science Translational Medicine Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors, using 10x Genomics Visium spatial transcriptome technology to analyze eight Single-cell resolution spatial transcriptome analysis of the dorsal root ganglia of donor organs identified 12 clusters of sensory neurons .
-
JEM︱Mechanisms of microglia regulating blood flow and neurovascular connections
Time of Update: 2022-04-29
Recently, the team of Ádám Dénes from the Budapest Institute of Experimental Medicine, Hungary, published a work entitled "Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions" in the Journal of Experimental Medicine, and found that microglia play a role in normal The mechanism of CBF regulation through P2Y12 receptor under physiological conditions and low perfusion [4] .
-
How will intensive and stable blood pressure lowering benefit patients with cerebral hemorrhage?
Time of Update: 2022-04-29
For a long time, how to improve the prognosis of patients with ICH has also been a key issue in the academic community, and strengthening and stable blood pressure reduction is an important principle of blood pressure management in the acute phase of ICH .
-
Review of Trends in Molecular Medicine by Li Jiayi/Li Wen team: "Death" signal in Parkinson's disease - iron death
Time of Update: 2022-04-29
Studies have shown that iron deposition and glial cell activation are closely related to dopaminergic neuron ferroptosis, and glial cells may participate in the process of neuron death by regulating neuronal iron homeostasis and oxidative stress .
-
Mol Psychiatry︱The role of biological clock gene Bmal1 in mouse models of autism and cerebellar ataxia
Time of Update: 2022-04-29
, Mol Psychiatry, 2022) Conclusions and discussions, inspiration and prospects Conditional knockout of Bmal1 either systemically or only in cerebellar Purkinje cells in a mouse model resulted in autism-related symptoms in mice, including loss of social activity and increased repetitive behaviors .
-
The remote control brain experiment was successful, but it scared the netizens
Time of Update: 2022-04-29
According to Hong Guosong, the corresponding author of the paper, the main purpose of this study is to achieve one of the biggest unmet needs in neuroscience through this non-invasive method - in mice under free activities (such as social interaction), Observe and record the function of specific brain cells and circuits deep in their brains .
-
Clinical overview of targeted gene-related ALS therapy
Time of Update: 2022-04-29
Last December, a team from the Department of Neurology at the University of Massachusetts synthesized and optimized an antisense oligonucleotide (ASO) targeting the GGGGCC repeat of the C9ORF72 gene, and demonstrated that it can safely and effectively reduce disease markers in patients with the genetic mutation.
-
Novel Parkinson's disease treatment based on artificial enzymes
Time of Update: 2022-04-29
Schematic of Prussian blue enzyme as an inhibitor of pyroptosis, an inflammatory cell death, in the treatment of Parkinson's disease.
As shown, after cells were treated with MPTP, Prussian blue enzyme scavenged the reactive oxygen species produced by the cells, thereby disrupting the NLRP3 inflammatory response chain that can lead to neuronal death .
-
Arterial thrombolysis with alteplase improves patient outcomes after successful stroke thrombectomy
Time of Update: 2022-04-29
This article is from the NEJM Journal Watch Review of Outcomes Improved with Intra-Arterial Alteplase After Successful Stroke Thrombectomy The early termination and small sample size of this phase 2b trial meant that a confirmatory study was warranted .
-
Nature sub-journal: New technology of deep brain neuromodulation based on near-infrared light
Time of Update: 2022-04-29
To verify the feasibility of this technique, the research team selectively expressed TRPV1 in dopamine neurons located in the ventral tegmental area of the mouse midbrain, and tested the effect of neuromodulation using a conditioned place preference experiment in the Y maze .
