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Review of Trends in Molecular Medicine by Li Jiayi/Li Wen team: "Death" signal in Parkinson's disease - iron death

 Last Update: 2022-04-29
 Source: Internet
 Author: User

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▲ Click the blue word above to follow CellPress Cell Science ▲ Life science Life science Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta and the loss of α-synuclein (α-synuclein, α-synuclein).
-syn) aggregated Lewy bodies and Lewy neurites
.

The exact pathogenesis of PD is still unclear
.

Studies have shown that iron deposition and glial cell activation are closely related to dopaminergic neuron ferroptosis, and glial cells may participate in the process of neuron death by regulating neuronal iron homeostasis and oxidative stress
.

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