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Review of Trends in Molecular Medicine by Li Jiayi/Li Wen team: "Death" signal in Parkinson's disease - iron death
Time of Update: 2022-04-29
Studies have shown that iron deposition and glial cell activation are closely related to dopaminergic neuron ferroptosis, and glial cells may participate in the process of neuron death by regulating neuronal iron homeostasis and oxidative stress .
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The first batch of express delivery in the world!
Time of Update: 2022-04-28
▎WuXi AppTec Content Team Editor Today, Sanofi announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) has approved the company's innovative enzyme replacement therapy Xenpozyme (olipudase alfa) for the treatment of acid sphingomyelinase deficiency ( acid sphingomyelinase deficiency, ASMD) non-central nervous system symptoms in adult and pediatric patients .
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The 17-year-old girl suddenly became unconscious, why?
Time of Update: 2022-04-28
Head CT, head MRI + MRA + DWI + SWI ➤ Qualitative analysis of the patient's coma, considering the damage to the cerebral cortex and the reticular ascending activation system; the patient's bilateral Chaddock was positive, and the right limb was occasionally moved by orbital pressure stimulation, and the left limb was not.
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PNAS: Oleic acid, activates the brain's "fountain of youth", a new way of anti-aging
Time of Update: 2022-04-28
The study shows that oleic acid produced by neural stem cells is an endogenous metabolic ligand for TLX, and oleic acid activates neurogenesis by binding to TXL, a discovery that opens the door to future TLX-based treatments that are expected to counteract aging by activating neurogenesis and cognitive impairment caused by disease .
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Stop Seizures Fast!
Time of Update: 2022-04-28
Zhou Dong, director of the Department of Neurology, West China Hospital of Sichuan University, head of the epilepsy and electroencephalography group of the Neurology Branch of the Chinese Medical Association, and vice president of the China Antiepileptic Association, said: " Alprazolam inhalation powder is being developed as a novel treatment for out-of-hospital treatment of epilepsy currently worldwide - Rapid Epileptic Seizure Termination (REST) therapy .
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Can aneurysms be treated like this?
Time of Update: 2022-04-28
. In addition, considering the three-dimensional relationship between the aneurysm neck angle and the parent artery, the surgical plan uses coils to loosely pack the patient's aneurysm to reduce the blood flow rate in the aneurysm to accelerate the healing process of the aneurysm .
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With pictures and texts: one article to grasp the anatomy of the medulla oblongata and common syndromes
Time of Update: 2022-04-28
➤Clinical manifestations: Includes a combination of medial and lateral medulla symptoms, such as ipsilateral cerebellar ataxia, facial sensory deficits, Horner syndrome, contralateral hemiparesis, and hemianesthesia .
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Mol Cell Shi Yun et al. Reveal the mechanism of small molecule inhibitor against axonal degeneration
Time of Update: 2022-04-28
Then, using the small molecule inhibitor 1AD as a tool, this paper used its high affinity to aggregate the TIR domains of the full-length SARM1 protein in the activated state, and successfully captured the cryo-electron microscope structure of the full-length SARM1 in the activated state for the first time.
Structural Basis of SARM1 Activation, Substrate Recognition, and Inhibition by Small Molecules.
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Read the article: Edema around cerebral hemorrhage
Time of Update: 2022-04-28
The patient's hematoma did not expand from 3 hours to 4 days after onset, but the surrounding edema gradually increased .
Three days after the onset of intracerebral hemorrhage, hemoglobin and iron-related toxicity resulting from lysis of red blood cells dominate the PHE process .
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Nature back to back!
Time of Update: 2022-04-28
Here, the study extracted amyloid fibrils from four donors diagnosed with type A to D FTLD-TDP and determined the structure at near-atomic resolution by cryo-electron microscopy .
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Nature's Whole-Brain Association Reproducibility Study
Time of Update: 2022-04-28
In general, the work found that brain-wide association studies between neuroimaging databases such as MRI and human behavior require larger sample sizes, at least thousands of data samples to ensure the authenticity of the association .
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What are the clues to the clinical diagnosis of headache?
Time of Update: 2022-04-28
The final diagnosis of the patient combined with further medical history and imaging examinations, we concluded that the final diagnosis of the patient was Spontaneous Intracranial Hypotension (SIH) caused by cerebrospinal fluid leakage .
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Protein & Cell Li Xiaojiang's team summarizes related research on large animal neurodegenerative disease models
Time of Update: 2022-04-28
The PINK1 knockdown non-human primate model established by CRISPR/Cas9 technology can simulate the pathological characteristics of neuronal cell death in Parkinson's patients, and reveal that PINK1 kinase is abundantly expressed in primate brain, phosphorylating a series of important neural functions protein to maintain the survival of nerve cells (experts commented on Protein & CellSubverting the classic theory, Li Xiaojiang's team revealed a new mechanism of hereditary Parkinson's disease) (Figure 1) .
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Do you know the diagnosis and treatment of intracranial vein and venous sinus thrombosis?
Time of Update: 2022-04-28
➤ For CVST patients with persistent or progressive symptoms despite medical treatment, or with signs of thrombus expansion, CTV or MRV examinations are recommended for early follow-up .
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Intravenous immunoglobulin for chronic inflammatory demyelinating polyneuropathy
Time of Update: 2022-04-28
The primary outcome was the rate of remission in the standard-dose group, defined as a ≥1-point improvement in the adjusted Inflammatory Neuropathy Cause and Treatment (INCAT) scale score (a measure of upper and lower extremity disability).
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Nap too long, Alzheimer's?
Time of Update: 2022-04-28
The researchers found that for people without cognitive impairment, nap time increased by an average of 11 minutes per year with age .
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List of migraine preventive treatment drugs, quickly collect!
Time of Update: 2022-04-28
The "Chinese Expert Consensus on Diagnosis and Treatment of Migraine and Depressive Disorders" (2020) pointed out that the class A recommended preventive treatment drugs for migraine are flunarizine, valproic acid, topiramate, metoprolol, propranolol ; Grade B recommended gabapentin, bisoprolol, venlafaxine, amitriptyline, candesartan, lisinopril .
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Front Cell Neurosci︱Shi Peng/Liu Zhen’s research group collaborated to reveal the shared molecular mechanism of sensorineural hearing loss caused by multiple factors
Time of Update: 2022-04-28
Through transcriptome sequencing analysis and related functional verification of the cochleae of three mouse models of hearing loss induced by aging, noise exposure and the ototoxic drug cisplatin, the multi-factor sensorineural hearing loss was systematically revealed.
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Can the old drug suramin sodium cure the sequelae of the new crown?
Time of Update: 2022-04-28
Naviaux studies using suramin sodium for the treatment of autism for decades have achieved statistical significance in two animal models of ASD and a small clinical trial [1,2,3] .
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Nature Methods: Next-Generation Stealth HYBRiD Technology Visualizes Whole Body Tissues of Animals, Helping Scientific Research
Time of Update: 2022-04-28
Another transparent brain technology based on hydrogel (acrylamide) and water, such as CLARITY technology, has good transparent effect, high signal-to-noise ratio of endogenous fluorescent signal, does not cause tissue shrinkage, but requires electrophoresis equipment, and the clearing time is relatively short.
