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Time of Update: 2022-04-28
The normal flow is still that the dendrites of the dopamine neuron receive the signal, then the neuron transmits the action potential to the axon, and finally the dopamine is released .
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Is it difficult to get started with cranial anatomy?
Time of Update: 2022-04-28
*For reference of medical professionals only, read the collection quickly! In order to become an excellent neurologist, it is essential to learn the basics of cranial anatomy. The author has also ta
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The field of express epilepsy is approved again, and the prospect of fenfluramine "old drug new" is promising
Time of Update: 2022-04-28
S. Food and Drug Administration (FDA) has approved the expanded indication of Fintepla (fenfluramine) for the treatment of patients two years of age and older with Lennox- Seizures associated with Gastaut syndrome (LGS) .
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Front Mol Neurosci︱ Gao Shangbang's research group analyzes the composition and molecular mechanism of motor neuron oscillators
Time of Update: 2022-04-28
In this study, the authors found that the rhythmic postsynaptic currents (rPSCs) output by motor neurons actually consist of multiple components, and at least six different ion channels are involved in the regulation of A-MNs-rPSCs .
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Rare "see" the dawn - Ruijin Hospital prescribes Quanxinda® (ofatumumab)
Time of Update: 2022-04-28
Zhou Qinming, the chief physician of the Department of Neurology, Ruijin Hospital, administered Quanxinda® (ofatumumab) injection for MS patients to treat two young children with muscle weakness.
In addition to multiple sclerosis, autoimmune encephalitis and other diseases, other rare, The treatment of difficult patients has always been the direction we stick to .
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Nature sub-issue: Han Minghu's team reveals that VTA-BLA projection neurons encode anxiety rather than depressive behavior
Time of Update: 2022-04-28
To search for the neural mechanisms of anxiety-like behaviors, the team focused on anxiety-related brain nuclei, AMG, retrogradely labeled VTA-BLA DA neurons and examined their Basal firing frequency, it was found that compared with the control group, the basal firing frequency of AD and A mice was significantly reduced (Figure 3) .
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Express 100 million US dollars to help develop precise Parkinson's disease therapy, the main drug will enter clinical development this year
Time of Update: 2022-04-28
The company said it has identified a potential "best-in-class" blood-brain barrier-crossing LRRK2 inhibitor called NEU-723 as a clinical candidate for Parkinson's disease .
"Reference: [1] Neuron23 Closes $100 Million Series C Financing Round, Nominates Clinical Candidate for Parkinson's Disease.
Retrieved March 30, 2022, from https:// million-series-c-financing-round-nominates-clinical-candidate-for-parkinsons-disease-301513270.
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Nat Commun︱Guo Ming's team discovered a new mechanism of mitochondrial fission and a new target for the prevention and treatment of Parkinson's disease
Time of Update: 2022-04-28
In the follow-up research to further explore the functions of PINK1 and parkin, Professor Guo Ming's team found that PINK1 and parkin regulate mitochondrial morphology[2], and combined with the Drosophila model and human cell model, they successively found that the genes MUL1, VCP/p97, Atg1 can effectively inhibit the The mitochondrial damage caused by the deletion of PINK1 and parkin provides multiple potential drug targets for the prevention and treatment of PD[3-5] .
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Do brain cells use one less than one?
Time of Update: 2022-04-28
The research team looked at the brains of donors of different ages and measured carbon-14 levels in neurons in different regions of the hippocampus .
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Current Biology: Professor Zhong Chen discovers histamine-like neural circuits with potential to treat obesity
Time of Update: 2022-04-28
The above study found that activation of the TMN-HA→MS loop inhibited feeding, but this inhibitory effect no longer existed in the activation of excitatory neurons in the MS region .
These results suggest that the TMN-HA→MS loop regulates feeding behavior through histamine type 2 receptors .
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Induce iPSC-derived neurons!
Time of Update: 2022-04-28
Recommended reading: Erythrocyte vectored tumor vaccine is applied for clinical application in China for the treatment of HPV-positive tumorsYimai Meng broke the news ▲ SQZ AACs platform (Image source: SQZ Biotechnologies) Sexual antigens squeeze red blood cells to form TACs.
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AS: The "high-precision compass" of the brain - a new type of head-direction cell in the somatosensory cortex
Time of Update: 2022-04-28
Abstract: Zhang Shengjia's research group from the Department of Neurosurgery of the Second Affiliated Hospital of Army Medical University used free-motion multi-channel electrophysiological recording technology to identify for the first time that there are both excitatory and inhibitory head direction cells in the somatosensory cortex.
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With a fatality rate of 100%, can this century-old disease usher in the dawn of innovative treatments?
Time of Update: 2022-04-28
S. FDA will convene an external committee of experts to discuss whether the clinical trial data of Amylyx's investigational therapy AMX0035 in patients with amyotrophic lateral sclerosis (ALS) support its regulatory approval .
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Axsome expands neuroscience pipeline
Time of Update: 2022-04-28
▎WuXi AppTec Content Team Editor On March 28, 2022, Axsome Therapeutics announced that it has reached a definitive agreement with Jazz Pharmaceuticals to acquire Sunosi (solriamfetol) .
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Speak with your mind!
Time of Update: 2022-04-28
Since the complete loss of eye movement ability is inevitable, the patient told the research team at the University of Tübingen that he hopes to have a brain-computer interface implanted to maintain communication with his family, especially his young son .
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The latest research finds: more than 1/4 of the elderly in rural areas are at high risk of dementia?
Time of Update: 2022-04-28
At the same time, this study suggests that advanced age, low education level and non-mental work may increase the risk of MCI, while the history of hypertension and stroke may increase the possibility of naMCI .
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Current Biology︱Chen Zhong's team made new achievements in the mechanism of histamine regulation of feeding: H2 receptor-dependent medial septal nucleus histaminergic circuit
Time of Update: 2022-04-28
Written by ︱Xu Lingyu Edited ︱Wang Sizhen Obesity is a disease caused by excessive accumulation of fat in the body, which can cause damage to liver and kidney function and increase the probability of
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Cell sub-journal: SUSTech Hou Shengtao's team jointly made a series of scientific research progress in the field of brain science
Time of Update: 2022-04-28
Recently, the team of Hou Shengtao, a professor at the School of Life Sciences, Southern University of Science and Technology, together with the University of Queensland Brain Research Institute, the German Center for Neurodegenerative Diseases and other units, published an online article entitled "Selenium mediates exercise-induced increases in adult neurogenesis and reverses the learning" in the academic journal Cell Metabolism.
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[Nature] A research team from Cornell University and UBC has discovered a substance that can fight all virus variants, which may become the latest solution to the new crown!
Time of Update: 2022-04-28
The researchers emphasized that the continued need for new coronavirus treatment options, especially the emergence of new sub-variants leading to a resurgence of cases, means that the pandemic "remains a significant threat to global health for the foreseeable future .
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2 Figure 3 Table to teach you the diagnostic chart summary of autoimmune encephalitis
Time of Update: 2022-04-28
Autoimmune encephalitis (AE) includes a group of noninfectious immune-mediated inflammatory diseases of the brain parenchyma, usually involving the cortex or deep gray matter, with or without involve
