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Recently, the team of Hou Shengtao, a professor at the School of Life Sciences, Southern University of Science and Technology, together with the University of Queensland Brain Research Institute, the German Center for Neurodegenerative Diseases and other units, published an online article entitled "Selenium mediates exercise-induced increases in adult neurogenesis and reverses the learning" in the academic journal Cell Metabolism.
Research paper on deficits induced by hippocampal injury and ageing"
.
Nervous system diseases related to population aging have become a heavy burden on the medical system in China and even in the world, causing various direct and indirect economic losses of hundreds of billions of yuan each year, becoming a huge economic burden on Chinese families and public health
.
China is the country with the highest death and disability rate of cerebrovascular disease (even 4 times higher than that of European and American countries), and the rate of increase is close to 9% every year, which has become the number one cause of death in China
.
Hou Shengtao's team has been conducting research on the basic neurobiology and clinical application of cerebrovascular disease for a long time.
He led the establishment of the "Joint Neuroscience and Neuroengineering Research Center" with the Brain Institute of the University of Queensland, Australia.
Cultivate outstanding compound talents, and make a series of research progress
.
The study uncovers an entirely new mechanism by which exercise mediates adult neurogenesis, during which mice produce a selenium-containing protein that helps their brains grow new neurons
.
This element can also be used to help reverse cognitive decline due to aging and brain damage, further elucidating the protective effect of dietary selenium supplementation on cognitive impairment caused by aging and stroke
.
The work attracted widespread attention, and Science published a follow-up report in the News column on the same day
.
Figure 1 Exercise and dietary selenium reverse cognitive impairment due to ageing and brain damage This is an "amazing" study, Barbara Cardoso, a nutritional biochemist at the Victoria Heart Institute at Monash University, told Science
.
Her own research shows that selenium, found in Brazil nuts, grains and some legumes, can improve verbal fluency and the ability to correctly reproduce pictures in older adults
.
"We can start to think about selenium as a strategy" to treat or prevent cognitive decline in people who cannot exercise or are more prone to selenium deficiency, such as the elderly, stroke and Alzheimer's disease patients, she said
.
In addition, Hou Shengtao's team recently published a research paper titled "Phosphorylation of Ser562/563 on GLT-1 by PKCα increases glutamate excitotoxicity in mice ischemic model" in Signal Transduction and Targeted Therapy with the Brain Science Center of Beijing Institute of Basic Medical Sciences, which clarifies that PKCα-mediated glutamate transporter-1 (Glt-1) phosphorylation at specific sites plays a key role in neuronal cell death in the acute phase of cerebral ischemia, providing a new target for the development of new drugs for stroke
.
Hou Shengtao's team also encouraged SUSTech undergraduates to work in the laboratory, laying a solid foundation for undergraduates to climb academic peaks
.
Recently, a research paper titled "40 Hz Light Flicker Alters Human Brain Electroencephalography Microstates and Complexity Implicated in Brain Diseases" independently completed by three undergraduate students in Hou Shengtao's team was published online on December 13, 2021 in the international academic journal Frontiers in Neuroscience
.
This study extends the previous work of Hou Shengtao's research group (South University of Science and Technology Hou Shengtao's team published research progress on light-to-neural network regulation in "Nature-Communication"), using 64-channel EEG recording equipment to study 20 adult volunteers receiving 40 Hz flickering Changes in EEG signals during photovisual stimulation
.
This study found for the first time the effects of 40 Hz flickering light stimulation on adult EEG microstates and characteristic indicators such as Lempel-Ziv complexity, which are affected to varying degrees in cognitive disorders such as stroke and Alzheimer's disease.
The next step of clinical treatment application has laid the foundation
.
The device has obtained a national patent (ZL.
2019 9 0000276.
6).
Fig.
2 The EEG activity map induced by 40Hz visual light stimulation Zhuo Zhan is the co-first author of the Cell Metab paper
.
Hou Shengtao, Professor Gerd Kempermann of the German Center for Neurodegenerative Diseases, and Tara L Walker, a researcher at the Brain Research Institute of the University of Queensland, are the co-corresponding authors of the paper
.
For the second STTT paper, visiting scholar Wang Yuqing of the School of Life Sciences of SUSTech is the first author, Hou Shengtao and academician Wang Yizheng of the Brain Science Center of the Beijing Academy of Basic Medical Sciences are the co-corresponding authors of the paper
.
Zhang Yiqi and Zhang Zhenyu, the 2018 undergraduates of the Department of Biology, School of Life Sciences, SUSTech, are the co-authors of the FN paper, and Hou Shengtao is the corresponding author.
The research was strongly supported by Professor Chen Fei from the Department of Electronics, Southern University of Science and Technology, and Tong Huaiyu, PLA 301 Hospital, as co-authors
.
The above papers are the first authors of SUSTech
.
The above work has been funded by the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province, the General and Key Projects of the Shenzhen Science and Technology Innovation Committee, the Peacock Program Talent and Innovation Project, and the Shenzhen-Hong Kong Brain Institute Team Project
.
Paper links: 1.
https:// 2.
https:// supplement-may-explain-brain-boost-exercise 3, https:// 4, https:// 16826-0
Research paper on deficits induced by hippocampal injury and ageing"
.
Nervous system diseases related to population aging have become a heavy burden on the medical system in China and even in the world, causing various direct and indirect economic losses of hundreds of billions of yuan each year, becoming a huge economic burden on Chinese families and public health
.
China is the country with the highest death and disability rate of cerebrovascular disease (even 4 times higher than that of European and American countries), and the rate of increase is close to 9% every year, which has become the number one cause of death in China
.
Hou Shengtao's team has been conducting research on the basic neurobiology and clinical application of cerebrovascular disease for a long time.
He led the establishment of the "Joint Neuroscience and Neuroengineering Research Center" with the Brain Institute of the University of Queensland, Australia.
Cultivate outstanding compound talents, and make a series of research progress
.
The study uncovers an entirely new mechanism by which exercise mediates adult neurogenesis, during which mice produce a selenium-containing protein that helps their brains grow new neurons
.
This element can also be used to help reverse cognitive decline due to aging and brain damage, further elucidating the protective effect of dietary selenium supplementation on cognitive impairment caused by aging and stroke
.
The work attracted widespread attention, and Science published a follow-up report in the News column on the same day
.
Figure 1 Exercise and dietary selenium reverse cognitive impairment due to ageing and brain damage This is an "amazing" study, Barbara Cardoso, a nutritional biochemist at the Victoria Heart Institute at Monash University, told Science
.
Her own research shows that selenium, found in Brazil nuts, grains and some legumes, can improve verbal fluency and the ability to correctly reproduce pictures in older adults
.
"We can start to think about selenium as a strategy" to treat or prevent cognitive decline in people who cannot exercise or are more prone to selenium deficiency, such as the elderly, stroke and Alzheimer's disease patients, she said
.
In addition, Hou Shengtao's team recently published a research paper titled "Phosphorylation of Ser562/563 on GLT-1 by PKCα increases glutamate excitotoxicity in mice ischemic model" in Signal Transduction and Targeted Therapy with the Brain Science Center of Beijing Institute of Basic Medical Sciences, which clarifies that PKCα-mediated glutamate transporter-1 (Glt-1) phosphorylation at specific sites plays a key role in neuronal cell death in the acute phase of cerebral ischemia, providing a new target for the development of new drugs for stroke
.
Hou Shengtao's team also encouraged SUSTech undergraduates to work in the laboratory, laying a solid foundation for undergraduates to climb academic peaks
.
Recently, a research paper titled "40 Hz Light Flicker Alters Human Brain Electroencephalography Microstates and Complexity Implicated in Brain Diseases" independently completed by three undergraduate students in Hou Shengtao's team was published online on December 13, 2021 in the international academic journal Frontiers in Neuroscience
.
This study extends the previous work of Hou Shengtao's research group (South University of Science and Technology Hou Shengtao's team published research progress on light-to-neural network regulation in "Nature-Communication"), using 64-channel EEG recording equipment to study 20 adult volunteers receiving 40 Hz flickering Changes in EEG signals during photovisual stimulation
.
This study found for the first time the effects of 40 Hz flickering light stimulation on adult EEG microstates and characteristic indicators such as Lempel-Ziv complexity, which are affected to varying degrees in cognitive disorders such as stroke and Alzheimer's disease.
The next step of clinical treatment application has laid the foundation
.
The device has obtained a national patent (ZL.
2019 9 0000276.
6).
Fig.
2 The EEG activity map induced by 40Hz visual light stimulation Zhuo Zhan is the co-first author of the Cell Metab paper
.
Hou Shengtao, Professor Gerd Kempermann of the German Center for Neurodegenerative Diseases, and Tara L Walker, a researcher at the Brain Research Institute of the University of Queensland, are the co-corresponding authors of the paper
.
For the second STTT paper, visiting scholar Wang Yuqing of the School of Life Sciences of SUSTech is the first author, Hou Shengtao and academician Wang Yizheng of the Brain Science Center of the Beijing Academy of Basic Medical Sciences are the co-corresponding authors of the paper
.
Zhang Yiqi and Zhang Zhenyu, the 2018 undergraduates of the Department of Biology, School of Life Sciences, SUSTech, are the co-authors of the FN paper, and Hou Shengtao is the corresponding author.
The research was strongly supported by Professor Chen Fei from the Department of Electronics, Southern University of Science and Technology, and Tong Huaiyu, PLA 301 Hospital, as co-authors
.
The above papers are the first authors of SUSTech
.
The above work has been funded by the National Natural Science Foundation of China, the Natural Science Foundation of Guangdong Province, the General and Key Projects of the Shenzhen Science and Technology Innovation Committee, the Peacock Program Talent and Innovation Project, and the Shenzhen-Hong Kong Brain Institute Team Project
.
Paper links: 1.
https:// 2.
https:// supplement-may-explain-brain-boost-exercise 3, https:// 4, https:// 16826-0
