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Living at the "peak" of life at the age of 35?
Time of Update: 2022-04-28
At each exam and at three age groups (35-50, 51-60, 61-70) in adulthood, the researchers assessed Alzheimer's disease with multiple known risk factors for cardiovascular disease and diabetes ( Includes links between good cholesterol (HDL-C), bad cholesterol (LDL-C), triglycerides, glucose, blood pressure, smoking, and body mass index) .
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Express treatment of childhood neuroblastoma, radioimmunotherapy submits marketing application
Time of Update: 2022-04-27
▎Y-mAbs Therapeutics, editor of WuXi AppTec's content team, recently announced that the company has completed the submission of the Biologics License Application (BLA) for the radioimmunotherapy I131-omburtamab to the US FDA .
"Reference: [1] Y-mAbs Announces Submission of Omburtamab Biologics License Application to FDA.
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J Neuroinflammation︱An Jing/Luan Guoming team work together to reveal a new pathogenesis of Rasmussen encephalitis
Time of Update: 2022-04-27
Written by ︱ Wang Yisong, Wang Peigang, Jing Jing editor ︱ Wang Sizhen Rasmussen encephalitis (Rasmussen's encephalitis, RE) is a chronic neurological disease of unknown etiology seen in children [1]
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What kind of positional dizziness/vertigo does the 13 patient "portraits" tell you might not be otolithiasis?
Time of Update: 2022-04-27
At this time, the high probability may not be otolithiasis, but more likely vestibular migraine or benign recurrent dizziness .
03 The patient had repeated attacks for several years, with only one positional dizziness/vertigo each time .
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Can statins reduce Parkinson's risk?
Time of Update: 2022-04-27
*For medical professionals to read and reference clinical information, the burden of 1s exposure to cerebrovascular disease pathology is associated with progressive Parkinsonism in the elderly, but it is unclear whether the use of statins can reduce the risk of Parkinsonism in the elderly risk .
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Consensus on diagnosis and treatment of dizziness/vertigo in the elderly, insightful analysis of mind maps
Time of Update: 2022-04-27
Elderly people often have a variety of chronic diseases, such as vision and hearing impairment, balance disorders, abnormal gait, orthostatic hypotension, heart disease, cognitive impairment of varying degrees, anxiety and depression disorders, sleep disorders, and multiple medications that cause dizziness.
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Nature Sub-Journal: Formyl Peptide Receptor Structure Brings New Opportunities for Alzheimer's Drug Development
Time of Update: 2022-04-27
(Photo provided by Beili Wu’s research group) FPR1 and FPR2 play important roles in host defense and inflammatory responses by binding to formyl peptides derived from bacteria or mitochondria, but these two FPRs are highly specific for the recognition of formyl peptides sex .
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Nat Biomed Eng︱Utilizes infrared light through the brain to modulate deep brain neural activity
Time of Update: 2022-04-27
The inner neurons express TRP protein, so as to achieve the purpose of regulating deep brain neural activity with near-infrared light (Fig.
In conclusion, this latest work reports the use of NIR-II light through the intact scalp and skull to modulate TRPV1 channel protein-expressing neurons in the deep brain of mice and sensitized by MINDS .
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How to reduce recurrence and death in stroke caused by intracranial atherosclerosis?
Time of Update: 2022-04-27
In March 2022, the American Academy of Neurology (AAN) published guidelines for stroke prevention in symptomatic intracranial atherosclerosis.
4. Clinicians should not routinely recommend angioplasty or indirect bypass surgery alone for stroke prevention in patients with sICAS .
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Exquisite jade pen, flowers all the way - Quanxinda® (ofatumumab) brings new hope to "beauty disease"
Time of Update: 2022-04-27
In the second year of ofatumumab treatment, nearly 90% of patients achieved the composite index of no recurrence, no new or enlarged lesions, and no disability progression-NEDA-3 (no evidence of disease activity) [4] .
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Courier for Alzheimer's Disease, Potential "first-in-class" NMDA Modulator Positive Phase 2 Clinical Results
Time of Update: 2022-04-27
▎Sage Therapeutics, editor of WuXi AppTec's content team, recently announced its potential "first-in-class" NMDA receptor allosteric modulator SAGE-718 for the treatment of mild cognitive impairment (MCI) and Alzheimer's disease (AD) Results of a phase 2 clinical trial in patients with mild dementia .
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Science: Indispensable!
Time of Update: 2022-04-27
Figure 2: Specific knockout of Igf1 in CD11c-positive microglia inhibits the process of pain self-healing Further molecular experiments showed that Igf1 expression in CD11c-positive microglia increased after peripheral nerve injury, reaching a peak at 5 weeks after injury .
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Bilateral thalamic infarction, unforgettable after reading
Time of Update: 2022-04-27
*For medical professionals to read for reference only, bilateral thalamic infarction is relatively rare in clinical practice.
1. Cranial MRI showed midbrain and bilateral thalamic infarction) (Fig.
Type III accounted for 14%, that is, bilateral paramedian area of thalamus and anterior thalamus, midbrain infarction .
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Nature sub-journal: Food cravings during pregnancy are derived from dopamine secreted by the brain
Time of Update: 2022-04-27
The authors reveal that pregnancy affects brain connectivity, particularly components of the dopamine circuit that is involved in the perception of rewarding stimuli and drives food-craving-like behaviors .
Nature Metabolism also distributed a review article entitled: Dopamine drives food craving during pregnancy .
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Nature︱On bacterial self-cultivation: a new mechanism to promote neuroinvasion and survival persistence
Time of Update: 2022-04-27
In-depth experiments showed that InlB blocked Fas-mediated killing of infected monocytes by CD8+ T cells, extending their lifespan and giving them the necessary time to adhere to brain blood vessels and put their cells inside the cells.
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Frontier Discovers 42 New Genetic Risk Factors for Alzheimer's Disease
Time of Update: 2022-04-27
▲The genetic risk loci associated with Alzheimer's disease found in this study (Image source: Reference [1]) One of the co-authors of the study, Professor Julie Williams, director of the UK Dementia Research Institute (UK Dementia Research Institute) The findings could rekindle efforts to find effective treatments, he said .
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JCI︱Liang Zhang/Zhanxiang Wang's team discovered that autocrine pathway regulates oligodendrocyte differentiation and promotes remyelination
Time of Update: 2022-04-27
Recently, Zhang Liang's team and Wang Zhanxiang's team from Xiamen University published a research paper entitled "Sec13 promotes oligodendrocyte differentiation and myelin repair through autocrine pleiotrophin signaling" in The Journal of Clinical Investigation, revealing that the process of oligodendrocyte differentiation is Physiological functions and mechanisms of action of COPII .
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New results have been achieved in the study of single neuron projection mapping in the mouse prefrontal cortex
Time of Update: 2022-04-27
On March 31st, Beijing time, Nature Neuroscience published a research paper titled "Projection Map of Mouse Prefrontal Cortex Single Neuron" in the form of a cover article. Scientific Research Insti
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What you should know about Meniere's disease｜Review the past and learn the new
Time of Update: 2022-04-27
➤Although the evidence is still lacking, systemic steroids should be considered in patients with co-morbid autoimmune disease, especially bilateral sensorineural hearing loss .
➤Intratympanic gentamicin therapy may be effective in reducing seizures in patients with significant loss of hearing vestibular function in the affected ear but with persistent severe seizures .
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Nature: The impact of new crown infection on the brain, even mild symptoms may cause potential brain damage!
Time of Update: 2022-04-27
The research experimental group included 8 adult monkeys, including 4 rhesus macaques (RM) and 4 African green monkeys (AGMs), who were infected with the original new coronavirus through multi-channel mucosal inoculation or aerosol atomization.
