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Nature: The impact of new crown infection on the brain, even mild symptoms may cause potential brain damage!
Time of Update: 2022-04-27
The research experimental group included 8 adult monkeys, including 4 rhesus macaques (RM) and 4 African green monkeys (AGMs), who were infected with the original new coronavirus through multi-channel mucosal inoculation or aerosol atomization.
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Express significantly improves the symptoms of Parkinson's disease patients, and the phase 2 clinical results of the new mechanism therapy are positive
Time of Update: 2022-04-27
▎WuXi AppTec Content Team Editors Today, Cerevance announced that its potential "first-in-class" oral Parkinson's disease treatment CVN424 has achieved positive results in a Phase 2 clinical trial .
" Reference: [1] Cerevance Reports Positive Phase 2 Clinical Trial Results with CVN424, a Parkinson's Disease Drug Working Through a New Mechanism.
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A quick look!
Time of Update: 2022-04-27
The results showed that, compared with the placebo group, Inclisiran could significantly reduce LDL-C levels and PCSK9 levels in HeFH patients (Figure 1).
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Tai Chi can delay dementia!
Time of Update: 2022-04-27
They found that for patients with chronic cognitive impairment (MCI), supplementing Tai Chi can significantly improve the effect of cognitive training .
Therefore, Professor Chen's team imagined that, perhaps, Tai Chi could further strengthen cognitive training and help delay cognitive decline in patients with mild cognitive impairment (MCI) .
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Have you mastered all these questions about the routine examination of Alzheimer's disease?
Time of Update: 2022-04-27
For healthcare providers who cannot perform CSF testing or advanced imaging, the American Institute of Neurological Disorders and the Alzheimer's Association and American Academy of Neurology propose core clinical criteria for the diagnosis of mild cognitive impairment .
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Express New Pain Relief Mechanism, Vertex's Ion Channel Inhibitor Obtained Phase 2 Clinical Proof of Concept
Time of Update: 2022-04-27
8 channel inhibitor VX-548 has two Phase 2 proofs of concept in the treatment of acute pain after abdominoplasty or bunionectomy Positive results in clinical trials .
" Reference Source: [1] Vertex Announces Statistically Significant and Clinically Meaningful Results From Two Phase 2 Proof-of-Concept Studies of VX-548 for the Treatment of Acute Pain.
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"Cell" sub-issue: Nicotinamide riboside may have neuroprotective effects!
Time of Update: 2022-04-27
They found in the first phase I clinical trial that oral nicotinamide riboside (NR) significantly increased the level of nicotinamide adenine dinucleotide (NAD) in the brain of patients with Parkinson's disease, altered brain metabolism, and reduced the serum levels of the subjects.
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What is the real culprit behind the severe headache?
Time of Update: 2022-04-27
The results of the CSF analysis are shown in the following table: Table 1 The CSF report is shown in Figure 1 (AB), and the cerebrospinal fluid ink staining (see Figure 1C) shows Cryptococcal infection .
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Wuhan University/Yale University team published the latest research results of stroke treatment
Time of Update: 2022-04-27
133) published online the latest research results of stroke treatment carried out by Wuhan University People's Hospital and Yale University School of Medicine and School of Biomedical Engineering.
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Express Myasthenia Gravis subcutaneous injection therapy reaches the end of Phase 3 clinical trial, plans to submit regulatory application this year
Time of Update: 2022-04-27
The trial met its primary endpoint of reduced immune globulin G (IgG) levels from baseline in patients with generalized myasthenia gravis (gMG) at 29 days of treatment, in line with the drug's approved intravenous (IV) formulation, Vyvgart (efgartigimod alfa).
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The classic Möbius syndrome that cannot be missed in many pictures
Time of Update: 2022-04-27
Image source: Department of Radiology, Americas Medical City, Americas Serviços Médicos, Brazil, 2019 Figure 3: Sagittal FIESTA of the internal auditory canal showing facial nerve loss, with thick yellow arrows indicating its usual location .
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How to distinguish "otolithiasis" from "central positional vertigo"?
Time of Update: 2022-04-27
Warning signal 6: CPPV prompts Figure 1 Nystagmus that is inconsistent with the stimulated semicircular canal plane Dix-Hallpike maneuver stimulates the vertical semicircular canal, and upward nystagmus with a rotating component (uprotation nystagmus) occurs, because the posterior semicircular canal is excited on the same side The cause of the superior oblique muscle and the contralateral inferior rectus muscle, if it induces downward nystagmus (positional downward nystagmus), suggests a central source of damage .
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Cell sub-journal: Developmental adversity causes abnormal synaptic pruning, and adults are unresponsive to threats
Time of Update: 2022-04-27
Baram's research team published an article in Cell Reports, revealing that adverse stress events during development cause microglial phagocytosis dysfunction, enhanced CRH neuron excitatory input in the PVN region, and adulthood A behavioral disorder that exhibits a blunted response to threatening behavior .
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"Cell Metabolism": Ptprd was first discovered to be a specific receptor of the appetite-stimulating hormone Asprosin in the central nervous system
Time of Update: 2022-04-26
But Atul Chopra's team found that Olfr734 was not expressed in AgRP neurons that respond to Asprosin and mediate the appetite-regulating effect of Asprosin .
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Cell: Tsinghua Ge Liang's team provides new therapeutic targets for neurodegenerative diseases | Cell Press Dialogue with Scientists
Time of Update: 2022-04-26
Life science On April 1, 2022, Ge Liang's team from the School of Life Sciences of Tsinghua University published a research paper entitled "CCT2 is an aggrephagy receptor for clearance of solid protein aggregates" in the Cell Press journal Cell .
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Nat Commun︱New progress in monitoring technology of cerebral cortex activity in free state of small animals: intelligent optical fiber two-photon microscope
Time of Update: 2022-04-26
In this research, the research group developed a high-speed sparse sampling fiber-scanning two-photon microscope, the imaging frame rate was increased by more than 10 times to 26fps, and the deep learning architecture was used for image enhancement to provide better image quality .
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With pictures and texts: an article to grasp the brainstem syndrome caused by developmental abnormalities
Time of Update: 2022-04-26
Figure 1 Möbius Syndrome, Axial (a, b) and sagittal (c) t2-weighted images showing loss of abducens and facial nerves at the level of Merkel's cavity .
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Nat Commun︱Guan Jisong's group discovered an important indexing mechanism of the hippocampus for memory storage
Time of Update: 2022-04-25
The researchers found that inducing cortical synchronization (iSOS) by activating neuronal projections from the LEC to the cortex not only rescued the deficits of fear memory in hippocampal-damaged mice (Fig.
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NBT Dai Qionghai and others developed an artificial intelligence method for fusion analysis of cell microscopic images and genetic data—MUSE
Time of Update: 2022-04-25
Altschuler of UCSF and the team of Academician Dai Qionghai of Tsinghua University (co-authored as Bao Feng and Yue Deng) published an article in Nature Biotechnology Integrative spatial analysis of cell morphologies and transcriptional states with MUSE, proposes an artificial intelligence method for the fusion analysis of cell microscopic images and gene data.
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Review of Nat Rev Neurosci︱ Yulong Li's team was invited to write a review of new technologies for neurotransmitter detection
Time of Update: 2022-04-25
It is worth mentioning that on March 22, 2022, Li Yulong's team and Lin Tian's team from UC Davis were invited to co-author a paper entitled "Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors" research review .
