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Stroke is the "number one killer" that endangers human health, and human's counterattack has never stopped
.
The latest issue of the top international biomedical engineering journal "Bioactive Materials" (instant IF=16.
133) published online the latest research results of stroke treatment carried out by Wuhan University People's Hospital and Yale University School of Medicine and School of Biomedical Engineering.
.
The research team has developed a series of nanoparticles derived from medicinal natural product small molecule compounds, which can be used as both effective drugs for stroke treatment and as effective carriers for drug delivery targeting stroke areas, providing a promising solution for stroke drug treatment.
new treatment modalities
.
Zhang Shenqi introduced that stroke has become the leading cause of death in China and the leading cause of disability among adults in China.
It has the characteristics of high morbidity, high mortality and high disability rate.
burden
.
The traditional therapeutic drugs cannot effectively penetrate the blood-brain barrier, and the therapeutic effect is unsatisfactory
.
Medicinal natural products are the main active ingredients of many traditional Chinese herbal medicines, but because more than 90% of medicinal natural product small-molecule compounds have poor water solubility, short in vivo half-lives, and low targeting, they are difficult to penetrate the blood-brain barrier and cannot be absorbed.
It is widely used in the drug treatment of stroke patients
.
In this context, the research team screened out a series of medicinal natural product small molecule compounds, and synthesized medicinal natural product small molecule compound nanoparticles by nano-supramolecular self-assembly method, which have good water solubility, blood stability and blood-brain Barrier permeability
.
The research team also found that betulinic acid is one of the most effective antioxidants in the treatment of stroke
.
By applying chemical synthesis technology, the amino group of betulinic acid is added to generate the amine derivative betulin, and the synthesized betulin nanoparticles can rapidly release drugs in the acidic stroke microenvironment
.
Modification of CXCR4 antagonist AMD3100 on the surface of betylamine nanoparticles can enhance its ability to actively target the stroke area, and by encapsulating the neuroprotective peptide NA1, its efficacy in improving stroke can be further enhanced
.
According to reports, the research team reported the phased results of the research at the 2021 International Stroke Conference (ISC 2021), and the American Stroke Association (ASA) official website reported it, which has aroused strong international response and has strong clinical translation potential.
To provide a new treatment method for sniping stroke, benefiting more stroke patients around the world
.
Text/Yang Centu, correspondent of Qian Zhongjun, correspondent in Hubei/Wuhan University People's Hospital
.
The latest issue of the top international biomedical engineering journal "Bioactive Materials" (instant IF=16.
133) published online the latest research results of stroke treatment carried out by Wuhan University People's Hospital and Yale University School of Medicine and School of Biomedical Engineering.
.
The research team has developed a series of nanoparticles derived from medicinal natural product small molecule compounds, which can be used as both effective drugs for stroke treatment and as effective carriers for drug delivery targeting stroke areas, providing a promising solution for stroke drug treatment.
new treatment modalities
.
Zhang Shenqi introduced that stroke has become the leading cause of death in China and the leading cause of disability among adults in China.
It has the characteristics of high morbidity, high mortality and high disability rate.
burden
.
The traditional therapeutic drugs cannot effectively penetrate the blood-brain barrier, and the therapeutic effect is unsatisfactory
.
Medicinal natural products are the main active ingredients of many traditional Chinese herbal medicines, but because more than 90% of medicinal natural product small-molecule compounds have poor water solubility, short in vivo half-lives, and low targeting, they are difficult to penetrate the blood-brain barrier and cannot be absorbed.
It is widely used in the drug treatment of stroke patients
.
In this context, the research team screened out a series of medicinal natural product small molecule compounds, and synthesized medicinal natural product small molecule compound nanoparticles by nano-supramolecular self-assembly method, which have good water solubility, blood stability and blood-brain Barrier permeability
.
The research team also found that betulinic acid is one of the most effective antioxidants in the treatment of stroke
.
By applying chemical synthesis technology, the amino group of betulinic acid is added to generate the amine derivative betulin, and the synthesized betulin nanoparticles can rapidly release drugs in the acidic stroke microenvironment
.
Modification of CXCR4 antagonist AMD3100 on the surface of betylamine nanoparticles can enhance its ability to actively target the stroke area, and by encapsulating the neuroprotective peptide NA1, its efficacy in improving stroke can be further enhanced
.
According to reports, the research team reported the phased results of the research at the 2021 International Stroke Conference (ISC 2021), and the American Stroke Association (ASA) official website reported it, which has aroused strong international response and has strong clinical translation potential.
To provide a new treatment method for sniping stroke, benefiting more stroke patients around the world
.
Text/Yang Centu, correspondent of Qian Zhongjun, correspondent in Hubei/Wuhan University People's Hospital
