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What is the cause of progressive limb weakness and muscle atrophy for 10 years?
Time of Update: 2022-09-15
▌ Localization diagnosis: patients have progressive limb and facial muscle weakness, with muscle atrophy, mild elevation of muscle enzymes, electromyography and muscular pathology suggest muscle-induced damage, which can be localized as a disease of the skeletal muscle system.
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Predict Alzheimer's disease 17 years in advance! These two blood test indicators are expected to bring about a change in early diagnosis!
Time of Update: 2022-09-15
In the current study, based on the study data from subjects in the ESTHER cohort (n=308), the researchers analyzed the association between the degree of Aβ misfolding (pathological changes in the early stages of AD disease) and plasma marker levels (P-tau181, GFAP, and NfL) levels, and explored effective predictors of AD diagnosis in the general population.
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Research express | "old therapies" have a significant impact on pediatric brain tumors
Time of Update: 2022-09-14
"Disulfiram [DSF], a drug that has been used to treat chronic alcoholism for nearly 70 years, is promising to be 'repurposed' as an anti-cancer agent, especially when it is complexed with metal ions such as copper [Cu++]," said Study senior author Betty Tyler, an associate professor of neurosurgery at the Johns Hopkins University School of Medicine.
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European Radiology: Comparison of head and neck single-energy and dual-energy CT image quality
Time of Update: 2022-09-14
Therefore, it is unclear whether DECTWAI reconstructions can produce the same or even higher image quality compared to single-energy images obtained with TVAs on dual-source CT scanners.
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Nat Commun – Ye Keqiang's team found that the TrkB agonist prodrug R13 inhibits bone loss
Time of Update: 2022-09-14
Written by Wang Mengmeng, Ye KeqiangEditor-in-charge - Fang Yiyi, Wang SizhenEdit— Square to oneOsteoporosis is a systemic bone disease characterized by the destruction of bone mass and normal bone st
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[One case per day] Chinese Journal of Neurosurgery: A case of primary central nervous system vasculitis with magnetic resonance-like brain tumors
Time of Update: 2022-09-14
Sagittal enhancement T1WI after 24 months of immunosuppressive therapy shows that the lesion disappearsFig. 2 Surgical specimen pathology: more lymphocyte infiltrates (HE×100) can be seen in the vascular wall and perivascular, which are confirmed by immunohistochemical CD20 staining as B lymphocytesPrimary angiitis of the central nervous system (PACNS) is a rare autoimmune disease that involves only the central nervous system and is not accompanied by extra-central nervous system damage.
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No wonder it's so hard to lose weight! "Nature" new discovery: addicted to sugar and fat, the intestines and brain have to "carry the pot"
Time of Update: 2022-09-14
▎ WuXi AppTec content team editor The craving for sugar and oil has penetrated deeply into our brains, guiding our definition of food, and indirectly leading to the prevalence of metabolic diseases such as diabetes and obesity.
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The Mol Neurobioloby-Yang Li/Long Cheng research group reveals molecular pathways for microglia to mediate anxious behavior caused by chronic stress
Time of Update: 2022-09-14
In this study, the authors found that chronic unpredictable mild stress (CUMS) administered to C57 mice for three weeks raised levels of the pro-inflammatory cytokines IL-1β, IL-6, TNFα, ROS-mediated oxidative stress, and mitochondrial lysis protein Drp-1 while causing anxious behaviors and hyperactivation of mPFC and HIPP microglia It reduced levels of ATP synthesis, nicotinylcholinergic α7 receptor (nAChRα7), Nrf-2 for protecting cells, and GABA signaling pathway key proteins (GS, Vgat, GABAα1R).
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New nature: Why do you like to eat greasy food? Scientists have revealed the mechanism of the gut-brain axis loop that favors fat
Time of Update: 2022-09-14
Click on the blue word to follow usHumans and animals have a preference for high-sugar, high-fat foods, in part because they are high in energy. Interestingly, mice lacking sweetener receptors could s
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Du Yifeng, Wang Lihua, Cao Yongjun Interview: Vascular re-communication "joins hands" with TK supplementary treatment to improve the efficacy of AIS treatment and achieve a better prognosis for patients!
Time of Update: 2022-09-14
Therefore, rapid open collateral circulation can help intravenous thrombolysis and interventional therapy to better achieve the purpose of improving perfusion and salvaging the semi-dark band, thereby increasing the effective remission rate and prolonging the treatment time window.
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Nature: Up knowledge - 1cm makes heat production faster! Scientists reveal brain-fat "small projection" that regulates the body's thermogenic "big function"
Time of Update: 2022-09-14
1038/s41586-022-05137-7The pictures in the article are from referencesClick on the blue word to follow us1 Dorsal root ganglia innervate the sensory fibers of fatFigure 1: Tissue transparency technique showing intact brain-fat projected fibers2The fibers that dominate adipose tissue regulate the expression of genes associated with thermogenesisFigure 2: Fibers that dominate fat regulate thermogenesis3The fibers that innervate adipose tissue regulate the body's thermogenesisFigure 2: Induction of thermogenesis after knocking out of innerted fat fiberssummary【References】1.
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Science blockbuster! Chinese scientists released the world's first "brain regeneration map"!
Time of Update: 2022-09-14
Cell type annotation, cell spatial distribution, gene activity dynamics, and cell state transitions were analyzed, and the mechanism of injury-induced regeneration was studied compared with these cellular properties during development 。 The findings were published in the September 2, 2022 issue of the journal Science, "Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration.
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【Philips 1 case per day】Intracranial tuberculosis is misdiagnosed as a case of intracranial metastatic malignancy
Time of Update: 2022-09-14
Sudden speech inability during intravenous infusion during 40 days of admission, weakness of the right limb with movement disorders, referral to a municipal hospital, check cerebrospinal fluid routine, biochemical examination without obvious abnormalities, diagnosis: (1) cerebral infarction; (2) Intracranial infection?
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[PHILIPS 1 case per day] 1 case of cervical vertebral neurofibroma
Time of Update: 2022-09-14
Fig. 1 shows that the soft tissue window artery stage after cross-section CT enhancement shows mild strengthening of the flaky patches scattered within the cervical 6 spinous lesions; Fig. 2 is a CT s
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Nature Sub-Journal: Artificial intelligence provides a digital biomarker for the diagnosis of Parkinson's disease
Time of Update: 2022-09-14
In the new study, the team developed a new AI-based neural network model for detecting Parkinson's disease, predicting disease severity, and using nighttime breathing ( that is, breathing characteristics during sleep ) to track the progression of the disease over time.
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Express 7:2! The innovative treatment of "frostbite" is supported by the FDA Expert Committee
Time of Update: 2022-09-14
▲The mechanism of AMX0035 (Image source: Amylyx official website)The efficacy of this therapy was supported by a Phase 2 clinical trial, CENTAUR, in which patients treated significantly reduced the average score decline compared to the placebo group after 24 weeks using alsfrs-R scores that comprehensively measure daily functioning in als patients.
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Evolutionary atlases at the molecular and cellular levels of the dorsolateral prefrontal cortex of Science primates
Time of Update: 2022-09-14
And through a comparative analysis between species based on this atlas, the authors revealed a wealth of cellular and molecular-level differences between species, including the discovery of species-specific cell subtypes, and the presence of primate-specific expression of a psychiatric disease susceptibility gene FOXP2 in excitatory neurons in the fourth layer of the cortex, as well as human-specific expression in microglia.
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Express Antisense oligonucleotide drugs have reached the end of clinical phase 3 and are scheduled to submit a listing application this year
Time of Update: 2022-09-14
The data showed that antisense oligonucleotide (ASO) therapy eplontersen achieved a common primary and secondary endpoint in the treatment of patients with hereditary transthyroxinin (TTR)-mediated amyloidosis multiple neuropathy (ATTRv-PN).
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NBE Sheng Xing/Li Xiaojian/Wang Shirong collaborated to discover that thin-film silicon photodiodes can selectively activate or inhibit neural activity
Time of Update: 2022-09-14
The development of novel neuromodulation techniques to activate and/or inhibit the activities of individual neurons or specific neural networks in real time and precisely is of great significance for
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For the first time, Bi Yan's team at Nanjing University found that exosomes mediate fat-brain-to-brain communication and promote the occurrence of diabetic cognitive dysfunction
Time of Update: 2022-09-14
Previous studies have shown that miRNAs are key molecules that play a biological role in adipose tissue EVs. Subsequently, through virus-mediated gene editing techniques, the researchers found that adipose tissue EVs can transport miRNAs to the hippocampal brain region, while targeting the removal of miRNAs in adipose tissue EVs can reduce cognitive impairment in diabetic mice.
