Evolutionary atlases at the molecular and cellular levels of the dorsolateral prefrontal cortex of Science primates

Written by Ma Shaojie

Editor-in-charge - Wang Sizhen

Editor — Binwei Yang

The long evolution has allowed us to develop a series of advanced cognitions and complex social behaviors

In the study, the authors first systematically analyzed a total of about 600,000 nuclear transcriptomes from adult humans, chimpanzees, rhesus macaques, and marmosets with a total of about 600,000 nuclear transcriptomes from the dorsolateral prefrontal cortex (Figure 1A

Taken together, the study systematically presented a high-resolution cell type atlas of the primate prefrontal cortex and revealed evolutionary homology to these cell subtypes, finding numerous cross-species differences at the cellular and molecular levels, including human-specific variations

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