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Adipose tissue "talks" to the central nervous system to maintain a whole-body energy balance1
Dorsal root ganglia innervate the sensory fibers of fat
The researchers injected the anterograde tracer virus into the DRG region of pan-DRG-cre mice (targeting DRG sensory neurons) and found that the virus-carrying GFP protein projected into the inguinal white adipose tissue under tissue transparency technique, clearly visible, this projection length is about 1.Figure 1: Tissue transparency technique showing intact brain-fat projected fibers
2
The fibers that dominate adipose tissue regulate the expression of genes associated with thermogenesis
By designing techniques that target fat sensory fibers, the researchers employed crease-dependent diphtheria toxoid A to specifically reduce DRG projection into adipose tissue fibers (about 40 percent).Figure 2: Fibers that dominate fat regulate thermogenesis
3
The fibers that innervate adipose tissue regulate the body's thermogenesis
During surgical removal, sensory and sympathetic fibers cannot be distinguished, so techniques that selectively target sympathetic fibers are particularly importantFigure 2: Induction of thermogenesis after knocking out of innerted fat fibers
summary
Conventional wisdom holds that fat signaling is delivered to the brain【References】
1.
The pictures in the article are from references
