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Nat Microbiol | Gao Xiang's group and others reveal the pathogenic mechanism of Salmonella effector protein SopD
Time of Update: 2021-03-25
On February 19, 2021, Gao Xiang's research group from the State Key Laboratory of Microbial Technology of Shandong University and Professor Jorge Galán from Yale University published an article The Salmonella effector protein SopD targets Rab8 to positively and negatively modulate the inflammatory response in Nature Microbiology.
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Eat melon, the new coronavirus RNA will be integrated into the human genome?
Time of Update: 2021-03-25
In order to experimentally confirm the possibility of viral reverse transcription integration, the research group described that SARS-CoV-2 RNAs can be reverse transcribed in human cells by reverse transcriptase (RT) from the LINE-1 element or HIV-1 RT.
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Nature Microbiology | Shandong University and other multi-unit cooperation, Wang Haibo and others found that calcium signal transduction is essential for the survival of Listeria
Time of Update: 2021-03-25
The research found Listeria monocytogenes (an intracellular bacterial pathogen) inhibits LC3-related phagocytosis (LAP) by regulating mitochondrial Ca2 + (mtCa2 +) signaling in order to survive in the cell.
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The Xia Ningshao team of Xiamen University reveals the mechanism and key sites of CAR-mediated high-efficiency decapsidation of CVB virus
Time of Update: 2021-03-25
. This research can provide a key basis for the research of CVB vaccines and antiviral drugs, enrich the understanding of the interaction mechanism between the virus and the receptor, and provide an important reference and theoretical basis for the development of high-efficiency broad-spectrum antiviral drugs targeting the viral receptor binding domain .
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JGG | Identification of melanin-forming genes of Shimeji mushroom based on high-quality genome deciphering and population genetics
Time of Update: 2021-03-25
This study analyzed the chromosome-level genome of Shimeji mushroom for the first time, clarified the evolutionary position of Shimeji mushroom in the phylum Basidiomycota, and identified related genes that control the gray-white color of the strain.
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The discovery and naming conventions of type VII toxin/antitoxin system | Cell Press Express Articles
Time of Update: 2021-03-25
Review article.
This article reports the discovery of type seven toxin/antitoxin (TA) and proposes the naming convention for type seven TA.
Researcher Wang Xiaoxue, the author, was invited to interpret the review article on the WeChat official account of Cell Press.
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Cell Review | Using CRISPR gene editing technology to analyze the biological problems of the new coronavirus
Time of Update: 2021-03-25
Scientists have obtained a large amount of information on the biology of SARS-CoV-2 based on the whole genome CRISPR-Cas9 screening method.
Finally, several host factors that help SARS-CoV-2 to leave the cell were also identified, such as phosphatidylinositol kinase (PIK3C3, PICfyve) and TMEM106B to allow the virus to leave the infected cell through exocytosis.
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The RNA virus polymerase revealed by Wuhan virus has a characteristic region related to host adaptation
Time of Update: 2021-03-25
Gong Peng’s team, a researcher at the Wuhan Institute of Virology, Chinese Academy of Sciences, has long been engaged in the study of the catalysis and regulation mechanism of viral RdRP.
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Nature Sub-Journal: In order to deal with antibiotics, bacteria actually staged a "metamorphosis"!
Time of Update: 2021-03-25
Specifically, through single-cell experiments, researchers found that the cells of Caulobacter crescentus, a commonly used model organism, can restore the growth rate before being stimulated by antibiotics and undergo significant changes in morphology.
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"Science" hot discussion: the genetic material of the new coronavirus will be inserted into the human genome!
Time of Update: 2021-03-25
They subsequently confirmed through in vitro cell line studies that part of the nucleic acid sequence of the new coronavirus can be integrated into the human genome based on the widespread LINE-1 retrotransposon in the human body or the HIV-1 reverse transcriptase in HIV-infected persons.
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Intestinal flora research: from correlation to causality
Time of Update: 2021-03-25
Three studies published last year identified the role of certain key bacteria in aggravating/alleviating cancer and metabolic diseases through in vitro culture of intestinal microbes.
coli strain isolated from colorectal cancer (CRC) tissue can produce a gene toxin that induces human intestinal organoids to develop mutations similar to those of CRC patients.
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A creature that feeds on hydrogen in the dark
Time of Update: 2021-03-25
. What is even more exciting for researchers is that the microbial communities under the glacier can combine hydrogen and carbon dioxide to produce more organic matter (ie biomass) through a chemical synthesis process.
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[Nature News] Blessed are those who love vegetarian food!
Time of Update: 2021-03-25
To help overcome the existing challenges associated with large-scale human research, the international research team launched the Individualized Response Study of Dietary Composition 1 (PREDICT 1) to study the interaction of diet-microbiome in metabolic health, a project involving individuals from the United States And British subjects.
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Science Advances | Great Discovery!
Time of Update: 2021-03-25
This study shows that methanogenesis already exists in the common ancestor of Euryarchaeota, TACK archaea and Asgard archaea, and it is likely to occur in the late Hadean or early Archean, and the ancestral methanogens depend on methylated compounds and hydrogen.
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Bacteria + Yeast =?
Time of Update: 2021-03-25
Recently, researchers from Imperial College and Massachusetts Institute of Technology took inspiration from a fermented tea, developed a new method of making these living materials, and created "living substances" that can be used to purify and filter water.
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Nature Protocols: The Baiyang Group of the Institute of Genetics and Development publishes a method for high-throughput isolation, culture and identification of root bacteria
Time of Update: 2021-03-25
Original link: https:// Nature Protocols: Baiyang Group of Institute of Genetics and Development of Chinese Academy of Sciences published an article detailing the experimental procedures and analysis of high-throughput isolation, culture and identification of plant root bacteria Methods The research of plant root microbiome mainly relies on high-throughput amplicon and metagenomic sequencing technology to describe the species classification and genetic composition of the microbiome.
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The map of known mosquito vectors and their viruses in my country is completed
Time of Update: 2021-03-25
Recently, researchers from the Wuhan Institute of Virology, Chinese Academy of Sciences investigated all Chinese and English documents related to "mosquitoes" and "viruses" published from 1953 to 2019 in China, and extracted information such as mosquito species, virus types, distribution, and time, and created The first known comprehensive geographic information dataset of vector mosquitoes and viruses in my country.
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Nature Sub-Journal: How to isolate, cultivate and identify root bacteria with high throughput
Time of Update: 2021-03-25
On January 13, 2021, Nature Protocols magazine published an online research paper titled "High-throughput cultivation and identification of bacteria from the plant root microbiota" from the Baiyang Group of the Institute of Genetics and Development of the Chinese Academy of Sciences.
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The Chinese Academy of Sciences Institute of Microbiology has made progress in the study of new coronavirus binding to pangolin receptors
Time of Update: 2021-03-25
Recently, "Science Bulletin" published the article "The molecular mechanism of new coronavirus binding to pangolin ACE2 receptor" by the research team of the Institute of Microbiology, Chinese Academy of Sciences.
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Small cells, big impact: RNA-protein complexes in cyanobacteria
Time of Update: 2021-03-25
Scientific question: What are the RNA-binding proteins involved in important post-transcriptional regulation processes in cyanobacteria that have not been clearly studied in other bacteria?
