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This article is converted Medicine original, reproduced please indicate the source Author: Cathy Introduction: Nobel laureate Joshua Lederberg has pointed out, the human body and human commensal microorganisms constitutes a super-organism (superorganism).
As the human body's largest and most complex microecosystem, the intestinal microorganisms themselves and their metabolites can not only regulate human health, but also play an important role as a bridge between the diet and the host.
Recently, a new study proved that a diet rich in healthy and plant-based foods is related to the composition and abundance of gut microbes.
Intestinal microbes are closely related to the risks of diseases such as obesity, type 2 diabetes and cardiovascular disease (CVD).
This multinational study was jointly completed by researchers from King's College London, Harvard University Chen Zengxi School of Public Health, Massachusetts General Hospital, University of Trento, Italy, and health science start-up ZOE.
The researchers said that this is the largest and most detailed study of its kind.
It applied metagenomics and blood chemistry analysis techniques and discovered 15 gut microbes that are associated with a variety of common disease risks.
At the same time, they also discovered some new microorganisms that have not yet been named.
The study was published in the journal Nature Medicine on January 11, entitled "Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals".
To help overcome the existing challenges associated with large-scale human research, the international research team launched the Individualized Response Study of Dietary Composition 1 (PREDICT 1) to study the interaction of diet-microbiome in metabolic health, a project involving individuals from the United States And British subjects.
They explained: "PredICT 1 involves more than 1,000 participants, using intensive clinical bioassays, blood testing, habitual diet data collection, continuous blood glucose monitoring, and stool metagenomics research to analyze dietary challenges before and after standardization.
" In this study, the researchers performed deep metagenomic sequencing on the 1,203 gut microbiomes of 1,098 individuals in the PREDICT 1 trial, and obtained detailed long-term dietary information of the subjects and hundreds of fasting and postprandial cardiometabolic events.
The level of blood markers.
There are many variables involved in studying the relationship between the microbiome, diet, and disease, because people’s diets are often personalized and can change a lot over time.
The two advantages of this experiment are the large number of participants, the large scale, and the very detailed information collected.
The analysis results show that the subject’s intestinal microbiome is closely related to specific nutrients, food types and diet composition, and certain microbes in the intestine are related to the level of biomarkers of metabolic diseases.
Surprisingly, the microbiome seems to be more closely associated with these markers than other factors (such as genetics).
The overall findings indicate that participants whose diets are rich in healthy, plant-based foods are more likely to have high levels of "good" gut microbes.
Conversely, diets containing highly processed plant-based foods are more likely to be related to "bad" gut microbes.
The study also identified microbial-based biomarkers for obesity, as well as markers for cardiovascular disease and impaired glucose tolerance.
Studies have also shown that the abundance of Prevotella copri and Blastocystis in the intestine is associated with maintaining good blood sugar levels after meals.
There are also some strains related to blood lipid levels and inflammation markers after a meal.
Researchers believe that their microbiome data can be used to help people who have not yet experienced symptoms determine the risk of cardiometabolic disease, and may help design a personalized diet that improves someone’s health.
The research team also found that the gut microbiota associated with healthy eating habits and the gut microbiota associated with good cardiometabolic and postprandial markers overlap with each other, indicating that these gut microbiome levels can be used to determine whether there is clinical The health of the individual with symptoms.
Dr.
Nicola Segata, professor and principal investigator of the Computer Metagenomics Laboratory of the University of Trento, Italy, said: “We are very surprised to find such a large community of “good” and “bad” microorganisms in the analysis.
Little is known, and these microorganisms have not even been named.
These effects of the gut microbiome on the human dietary response may help explain some of the heterogeneity found in previous human studies.
" Curtis of the Chen Zengxi School of Public Health, Harvard University Dr.
Huttenhower added: “Diet and gut microbiome are highly individualized.
PREDICT is one of the first studies that began to decompose this complex molecular network on a large scale.
This is a major focus for us.
In the future, we will continue to explore how Use the gut microbiome as an adjustable target to improve human metabolism and health.
"Reference: [1] https:// -diet-gut-microbes-metabolic-health/ [2] https:// Today’s video content recommendation [Trailer] Associate Professor Yang Xinrong of "My 2020"— —Chief physician of liver surgery in Zhongshan Hospital of Fudan University, focusing on tumor diseases and paying attention to the physical and mental health of tumor patients
As the human body's largest and most complex microecosystem, the intestinal microorganisms themselves and their metabolites can not only regulate human health, but also play an important role as a bridge between the diet and the host.
Recently, a new study proved that a diet rich in healthy and plant-based foods is related to the composition and abundance of gut microbes.
Intestinal microbes are closely related to the risks of diseases such as obesity, type 2 diabetes and cardiovascular disease (CVD).
This multinational study was jointly completed by researchers from King's College London, Harvard University Chen Zengxi School of Public Health, Massachusetts General Hospital, University of Trento, Italy, and health science start-up ZOE.
The researchers said that this is the largest and most detailed study of its kind.
It applied metagenomics and blood chemistry analysis techniques and discovered 15 gut microbes that are associated with a variety of common disease risks.
At the same time, they also discovered some new microorganisms that have not yet been named.
The study was published in the journal Nature Medicine on January 11, entitled "Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals".
To help overcome the existing challenges associated with large-scale human research, the international research team launched the Individualized Response Study of Dietary Composition 1 (PREDICT 1) to study the interaction of diet-microbiome in metabolic health, a project involving individuals from the United States And British subjects.
They explained: "PredICT 1 involves more than 1,000 participants, using intensive clinical bioassays, blood testing, habitual diet data collection, continuous blood glucose monitoring, and stool metagenomics research to analyze dietary challenges before and after standardization.
" In this study, the researchers performed deep metagenomic sequencing on the 1,203 gut microbiomes of 1,098 individuals in the PREDICT 1 trial, and obtained detailed long-term dietary information of the subjects and hundreds of fasting and postprandial cardiometabolic events.
The level of blood markers.
There are many variables involved in studying the relationship between the microbiome, diet, and disease, because people’s diets are often personalized and can change a lot over time.
The two advantages of this experiment are the large number of participants, the large scale, and the very detailed information collected.
The analysis results show that the subject’s intestinal microbiome is closely related to specific nutrients, food types and diet composition, and certain microbes in the intestine are related to the level of biomarkers of metabolic diseases.
Surprisingly, the microbiome seems to be more closely associated with these markers than other factors (such as genetics).
The overall findings indicate that participants whose diets are rich in healthy, plant-based foods are more likely to have high levels of "good" gut microbes.
Conversely, diets containing highly processed plant-based foods are more likely to be related to "bad" gut microbes.
The study also identified microbial-based biomarkers for obesity, as well as markers for cardiovascular disease and impaired glucose tolerance.
Studies have also shown that the abundance of Prevotella copri and Blastocystis in the intestine is associated with maintaining good blood sugar levels after meals.
There are also some strains related to blood lipid levels and inflammation markers after a meal.
Researchers believe that their microbiome data can be used to help people who have not yet experienced symptoms determine the risk of cardiometabolic disease, and may help design a personalized diet that improves someone’s health.
The research team also found that the gut microbiota associated with healthy eating habits and the gut microbiota associated with good cardiometabolic and postprandial markers overlap with each other, indicating that these gut microbiome levels can be used to determine whether there is clinical The health of the individual with symptoms.
Dr.
Nicola Segata, professor and principal investigator of the Computer Metagenomics Laboratory of the University of Trento, Italy, said: “We are very surprised to find such a large community of “good” and “bad” microorganisms in the analysis.
Little is known, and these microorganisms have not even been named.
These effects of the gut microbiome on the human dietary response may help explain some of the heterogeneity found in previous human studies.
" Curtis of the Chen Zengxi School of Public Health, Harvard University Dr.
Huttenhower added: “Diet and gut microbiome are highly individualized.
PREDICT is one of the first studies that began to decompose this complex molecular network on a large scale.
This is a major focus for us.
In the future, we will continue to explore how Use the gut microbiome as an adjustable target to improve human metabolism and health.
"Reference: [1] https:// -diet-gut-microbes-metabolic-health/ [2] https:// Today’s video content recommendation [Trailer] Associate Professor Yang Xinrong of "My 2020"— —Chief physician of liver surgery in Zhongshan Hospital of Fudan University, focusing on tumor diseases and paying attention to the physical and mental health of tumor patients
