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The collaborative research of Yu Yongfu's research group of Fudan University has made progress in the field of diabetes
Time of Update: 2023-01-06
This study demonstrates that children with diabetes have an increased risk of early onset kidney disease overall and specific types, and that preventing and treating diabetes early in childhood may significantly reduce the risk of developing kidney disease later in life.
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An unusual antibody shows super activity against Zika virus
Time of Update: 2023-01-06
" A team led by researchers at Weill Cornell Medical College, New York-Presbyterian Church, and the National Institutes of Health (NIH) has discovered an unusual antibody that neutralizes the Zika virus even at extremely low levels and makes the viral infection undetectable in preclinical models.
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PNAS Announces Revolutionary Gene Drive Technology: The First Results in Controlling Invasive Mice
Time of Update: 2023-01-06
"Leveraging a natural murine meiotic drive to suppress invasive populations Researchers at the University of Adelaide have published their first findings on the potential effectiveness of revolutionary gene drive technology in controlling invading mice.
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Diabetic hyperglycemia promotes primary tumor progression through glycation-induced extracellular stromal sclerosis
Time of Update: 2023-01-05
Inhibition of FAK-mediated cellular mechanical sensing slows the progression of diabetic tumors without affecting ECM stiffnessTo confirm that glycosylation promotes tumor progression by strengthening the tumor extracellular matrix (ECM), which in turn activates cellular mechanical sensing signals, STZ-injected mice were treated with the adhesion kinase (FAK) inhibitor PF573228 for 7 weeks until the end of the study.
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A large number of potential CRISPR-based genome editing tools have been discovered in the Cell viral genome
Time of Update: 2023-01-05
The researchers believe that these viruses use CRISPR-Cas to compete with each other and potentially manipulate the host's gene activity to their advantage.
The researchers believe that these viruses use CRISPR-Cas to compete with each other and potentially manipulate the host's gene activity to their advantage.
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Neuroimmune proteins can be used as biomarkers in the diagnosis of neurodegenerative diseases
Time of Update: 2023-01-05
Researchers from the BU CTE Center have found that immune-related proteins can help distinguish neurodegenerative diseases and provide additional candidates for biomarkers or novel therapeutic targets.
Researchers from the BU CTE Center have found that immune-related proteins can help distinguish neurodegenerative diseases and provide additional candidates for biomarkers or novel therapeutic targets.
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eLife: A coronavirus drug target that can prevent the immune system from shutting down
Time of Update: 2023-01-05
Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography Structural details of an attractive coronavirus drug target that could be used to combat SARS-CoV-2 and future pandemics were published today in eLife.
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Chinese scholars have made progress in the study of meningeal immunity in adult mice
Time of Update: 2023-01-05
Figure Stem cells were found to exert meningeal immunity in the steady-state meninges of adult mice With the funding of the National Natural Science Foundation of China (approval numbers: 81930027, 92169207, 81625010), Zhang Jiyan's team at the Beijing Brain Science and Brain-like Research Center found that adult mouse steady-state meninges have hematopoietic stem cells, and the research results were based on "Identification of hematopoietic stem residing cells in the adult mouse steady-state meninges.
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Science: The RNA-binding protein FMRP was found to allow tumors to evade recognition by the immune system and become resistant to immunotherapy
Time of Update: 2023-01-05
They then moved on to the main part of their study, which was to determine the functional significance of FMRP in these tumors--- they expressed this protein, but what role does it do?FMRP is associated with the immune systemTo explore this, the authors developed so-called "gene knockout" cancer cell lines.
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The researchers discovered a breast cancer protein that can predict chemotherapy sensitivity
Time of Update: 2023-01-05
"Alterations in the p53 isoform ratio govern breast cancer cell fate in response to DNA damageResearchers have identified a protein that, when present in large quantities in breast cancer tumors, is an indicator of whether DNA-damaging therapies are effective.
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Science: Revealed that the Hippo signaling pathway directs abnormal organ growth, but not normal organ growth
Time of Update: 2023-01-05
"To address this hypothesis, the authors studied two commonly used models of organ growth control, the eye of fruit flies and the liver of mice, in which they investigated the effects of loss of output from the Hippo signaling pathway on growth, its activity patterns during normal development, and genetic programs induced by experimental overactivation of Yap/Taz/Yki. Functional analysis of HIPPO signaling pathways in organ growth control.
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The deubiquitinase USP7 is a novel cyclin F interaction protein that regulates the stability of cyclin F protein
Time of Update: 2023-01-05
A new research paper, published in the journal Aging, titled "Deubiquitinase USP7 is a novel cyclin F interacting protein and regulates cyclin F stability.
A new research paper, published in the journal Aging, titled "Deubiquitinase USP7 is a novel cyclin F interacting protein and regulates cyclin F stability.
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Gene therapy for neurological diseases has taken a big step: viral vectors that cross the blood-brain barrier
Time of Update: 2023-01-05
Systemic administration of novel engineered AAV capsids facilitates enhanced transgene expression in the macaque CNS Gene therapy can treat, and may even cure, certain genetic diseases, but getting therapeutic drugs to the parts of the body that need them is a challenge.
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Zeng Yi's group discovered the mechanism by which Zeb1 regulates vascular endothelial stem cell rest
Time of Update: 2023-01-05
TRS_Editor A{font-family:;font-size:12pt;}On November 22, Cell Reports published online the latest research results of Zeng Yi Research Group of the Center for Excellence in Molecular Cell Science (Institute of Biochemistry and Cell Biology) of the Chinese Academy of Sciences, "Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence" entry”。 This study revealed the mechanism by which Zeb1 regulates the resting state of vascular endothelial stem cells by regulating the Wnt/β-catenin signaling pathway.
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The Chengdu Institute of Biology revealed the contribution of mycorrhizal fungi to the formation of soil aggregates during the secondary succession of subalpine forests
Time of Update: 2023-01-05
Particle size distribution of 4 aggregates (>2000; 250-2000 μ m； 53-250 μ m； by % in a indices were ( in grassland and shrubland succession in subalpine climates, while in In order to verify the above inference, Qiang Wei, a doctoral student in the research team of Pang Xueyong of the Chengdu Institute of Biology and Ecosystem Management, Chinese Academy of Sciences, selectedshrubland→→secondarysuccession soil of primary forest in subalpine areas.
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For the first time, the University of Oxford has discovered that drug-resistant bacteria can move from the intestines to the lungs
Time of Update: 2023-01-05
The study's findings also show that eliminating drug-resistant pathogens from the gut microbiome of hospitalized patients can prevent serious infections, and highlight how antibiotic use can have a profound impact on bacteria beyond the true target.
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Zhou Jing's group and collaborators constructed blood flow shear-responsive nanodiscs that can be used to resist vascular endothelial inflammation and atherosclerosis
Time of Update: 2023-01-05
On November 20, 2022, the research group of Zhou Jing, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University Health Science Center, and Gan Yong, Yu Miaorong, and others from the Shanghai Institute of Materia Medica, Peking University Health Science Center, published an online report in Small magazine Disturbed flow-facilitated margination and targeting of nanodisks protect against atherosclerosis.
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Nat Commun: Using DNA barcoding technology may reveal the ability of cancer cells to evade attacks by the host body's immune system
Time of Update: 2023-01-05
Although immune checkpoint inhibitors can effectively reactivate tumor immunity in some cancer types, many other solid tumors, including breast cancer, may be largely unresponsive, and understanding
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Luo Huan and Zhang Hang's research group published a paper in Progress in Neurobiology to reveal the dynamic emergence of relationship network structure in the human brain...
Time of Update: 2023-01-05
Emergence of higher-order structures in neural signaling and computational modelsIn summary, Luo Huan and Zhang Hang's research group combined behavioral, neural and computational models to reveal the neural mechanism and computer theory behind the human brain's extraction and learning from continuous picture streams, and then establishing the neural mechanism and computer theory of high-order statistical structure (intracluster compression and intercluster distance) from this low-order transfer probability.
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Professor Gao Shuai of Wuhan University cooperated with Professor Yan Ning, and Cell released the latest collaborative research results of drug regulation of calcium ion channels
Time of Update: 2023-01-05
News Network News (Correspondent Yang Peng) On November 22, Professor Gao Shuai of the School of Pharmacy of Wuhan University and Yan Ning, former Professor of Princeton University, jointly published the latest research results of drug regulation of calcium ion channels online in Cell (Cell) magazine.
