PNAS Announces Revolutionary Gene Drive Technology: The First Results in Controlling Invasive Mice

Researchers at the University of Adelaide have published their first findings
on the potential effectiveness of revolutionary gene drive technology in controlling invading mice.

The team developed the world's first proof-of-concept for the technology, called t-CRISPR
, using lab mice.

Using sophisticated computer modeling by co-first author Dr.
Aysegul Birand, the researchers also found that 250 genetically modified mice could wipe out 200,000 mice
on an island in about 20 years.

The results of this study were published in
the international journal Proceedings of the National Academy of Sciences.

Lead researcher Professor Paul Thomas, from the University of Adelaide and the South Australian Institute of Health and Medical Research (SAHMRI), said: "This is the first time a new genetic tool has been discovered to suppress invasive mouse populations
by inducing female infertility.

"The t-CRISPR method uses cutting-edge DNA editing technology to alter
a woman's fertility genetics.
Once the genetic modifications of this population reach saturation, all the females produced will not be fertile
.
”

"We are also developing a new version of t-CRISPR technology that aims to target specific pest populations and prevent the unwanted spread of
gene drives.
"

Luke Gierus, a graduate student and co-first author of the research paper, said t-CRISPR is the first genetic biological control tool
for invasive mammals.

"So far, the technology has targeted insects in an attempt to limit the spread of malaria, which kills 500,000 people worldwide each year
," said Mr Gierus.

"The use of t-CRISPR technology provides a humane approach to controlling invasive mice without releasing toxins
into the environment.
We are also investigating strategies to prevent eradication failures due to the emergence of gene drive resistance in the target population.
"

The research team has worked closely with CSIRO, Australia's national science agency, the Invasive Species Solutions Centre, the Invasive Rodent Genetic Biological Control (GBIRd) Alliance and the U.
S.
Department of Agriculture to consider next steps
for the safe implementation of the new technology.

Professor Thomas said: "Our wider project includes consideration of social perspectives and attitudes as part of
our ongoing research related to gene drives.
"

Dr.
Owain Edwards, leader of CSIRO's Environmental Mitigation and Recovery Group, added: "This particular prototype was designed to be highly specific to mice, but it also demonstrates that gene drives can be developed to combat other invasive harmful animals
.
"

"As part of this research, we conducted a safety assessment
of the highest standards for this technology.
Because this is the first prototype of a vertebrate gene drive, interested stakeholders will include many
from the international community.
”

The research was supported
by the South Australian Government and the New South Wales Government.

Dr Susan Close, MP, Deputy Prime Minister of South Australia, said: "These promising findings suggest that gene drive technology could be a game-changer
when it comes to managing the impact of mice on our environment, communities and agricultural sectors.
"