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New oral drug for lowering cholesterol in Cell Reports
Time of Update: 2023-01-05
Study resultsAt the heart of cholesterol regulation is the low-density lipoprotein receptor, which sits on the surface of liver cells and removes cholesterol from the blood, thereby lowering serum levels.
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Microplastics with different charges affect plant gene regulation and metabolism
Time of Update: 2023-01-05
Paper links: 1, 2, 3 Microplastics are plastic pollutants with a particle size of less than 5mm, which are widely detected in environmental media such as atmosphere, water and soil.
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A new sign of amyotrophic lateral sclerosis (ALS) reveals possible triggers for neurodegeneration
Time of Update: 2023-01-05
Corinne Houart, Professor of Developmental Neurobiology at King's College and lead author of the study, said: "Finding the same mRNA abnormalities in zebrafish SFPQ mutants and human ALS neurons opens up a new avenue for understanding neurodegenerative processes.
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Lung cancer progression can be predicted by the tumor stroma
Time of Update: 2023-01-05
Their findings, "Extracellular matrix mapping determines risk and prognosis of squamous cell carcinoma subtypes of non-small cell lung cancer," were published in the journal BMC Genomic Medicine.
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Biomarkers predict melanoma resistance to immunotherapy
Time of Update: 2023-01-05
Researchers at Duke Cancer Institute have identified potential biomarkers that predict the likelihood that checkpoint inhibitor drugs will backfire, driving hyperprogression in melanoma cells rather than releasing the immune system to fight them.
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The methyltransferase SMYD3 regulates a new function of hypoxic tolerance in the body
Time of Update: 2023-01-05
Recently, Xiao Wuhan's team from the Institute of Hydrobiology, Chinese Academy of Sciences revealed the mechanism by which methyltransferase SMYD3 inhibits hypoxic tolerance by activating the hypoxia signaling pathway, and this inhibitory function does not depend on the methyltransferase activity of SMYD3.
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Nature: The magical "hollow sphere" protein protects the genome of cancer cells
Time of Update: 2023-01-05
MYC proteins also show a previously unknown activity that now opens new doors for cancer research: They form hollow spheres that protect particularly sensitive parts of the genome.
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Mechanoregulation of the RNA-binding protein hnRNPC in a failed heart
Time of Update: 2023-01-05
Mechanical regulation helps clarify heart failuresummaryHeart disease is characterized by a strong remodeling of the extracellular matrix (ECM), which eventually leads to heart failure.
Mechanical regulation helps clarify heart failuresummaryHeart disease is characterized by a strong remodeling of the extracellular matrix (ECM), which eventually leads to heart failure.
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Nature Genetics' world's largest research has found new Alzheimer's genes
Time of Update: 2023-01-05
The study, titled "Exome sequencing identifies rare disruptive variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease," was published in Nature Genetics.
Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer's disease
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The drug triggers immune cells to attack prostate cancer
Time of Update: 2023-01-05
Image: According to new research from Washington University School of Medicine in St. Louis, a drug compound stimulates immune cells to attack prostate tumors.
Image credit: Nupam MahajanImage: According to new research from Washington University School of Medicine in St. Louis, a drug compound stimulates immune cells to attack prostate tumors.
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A common fungus removes toxic mercury from soil and water
Time of Update: 2023-01-05
Proceedings of the National Academy of Sciences, 2022; 119 (47) The researchers and his colleagues found that Metarhizium robertsii can remove mercury from soil, fresh water and salt water around plant roots.
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"Father of CAR-T" Cell Opinion Article: CAR-T cell therapy has gone beyond cancer
Time of Update: 2023-01-05
"Original:CAR T therapy extends its reach to autoimmune diseases Carl June, "CAR-T pioneer" and tenured professor at the Perelman School of Medicine at the University of Pennsylvania, was also named one of the "2018 Global Top 100 Influential People" by Time magazine for this achievement.
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Nature cover: Mammalian brain research makes a major discovery
Time of Update: 2023-01-05
Using this new method, the researchers studied mammalian enzymes isolated from rat brains for the first time.
Using this new method, the researchers studied mammalian enzymes isolated from rat brains for the first time.
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A new way to measure blood sugar levels without drawing blood
Time of Update: 2023-01-05
In this study, the research team proposed an electromagnetic-based sensor that could be implanted subcutaneously and be able to track small changes in the dielectric constant due to changes in BGLs. About one-fifth the weight of a cotton swab, this sensor can measure changes in glucose concentration in interstitial fluid (ISF) that fills the intercellular space.
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Lab-grown "mini-eyes" unlock understanding of blindness, a rare genetic disease
Time of Update: 2023-01-05
Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution Researchers at the Great Ormond Street Institute for Child Health (UCL GOS ICH) at University College London have developed "mini-eyes", which make it possible to study and better understand the development of blindness in a rare genetic condition, Ushel syndrome.
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HIV infection leaves a "memory" in cells
Time of Update: 2023-01-05
”Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells Picture of HIV.
”Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells Picture of HIV.
”Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells Picture of HIV.
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Wang Ying's research group in the School of Life Sciences collaborated to discover conserved molecular modules that regulate plant organogenesis
Time of Update: 2023-01-05
In this work, the researchers combined molecular genetics, laser confocal microscopy, transcriptome sequencing analysis and external hormone and chemical drugs to carefully track and compare the cytology process of non-homologous organ formation, and found that in seed plants and bryophytes, the common themes of axillary bud occurrence and leaf midvein formation are cell division, while GRAS family transcription factors LATERAL SUPPRESSOR (LAS) PROMOTES THE FORMATION OF THESE TWO NON-HOMOLOGOUS STRUCTURES BY REGULATING CELL DIVISION.
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Deep learning enhances cell image analysis capabilities
Time of Update: 2023-01-05
Article Deep Learning in Cell Image Analysis Cells are the basic structure and function of life, varying in size, shape, and density.
Article Deep Learning in Cell Image Analysis Cells are the basic structure and function of life, varying in size, shape, and density.
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Molecular Cell breaks down one of the deadliest cancers: how liver cells go astray
Time of Update: 2023-01-05
essayTranscription factors TEAD2 and E2A inhibit acetyl-CoA synthesis globally and promote tumorigenesis Image: One of the leading causes of liver cancer is excessive alcohol consumption.
essayTranscription factors TEAD2 and E2A inhibit acetyl-CoA synthesis globally and promote tumorigenesis Image: One of the leading causes of liver cancer is excessive alcohol consumption.
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How are microplastics different on both sides of the Atlantic?
Time of Update: 2023-01-05
” Image: Samples of different types of microplastics found by the expedition during their voyage across the North AtlanticImage credit: Sophie Dingwall/exppeditionAccording to a new study, the North Atlantic circulation waters contain significantly more plastic than other high seas areas, and plastic is made up of polymers produced by packaging, rope and paint particles.
