-
Chinese scholars have made progress in cosmic reionization research
Time of Update: 2022-02-16
11773051, 12022303), the team of researcher Zheng Zhenya from Shanghai Astronomical Observatory of the Chinese Academy of Sciences analyzed the observation data of the famous deep-field GOODS-S of the Hubble Space Telescope (HST) and found a case at redshift.
-
Science Life Center Qu Lijia has made another major textbook discovery!
Time of Update: 2022-02-16
At the beginning of 2022, the internationally renowned journal Science published a research paper titled "RALF peptide signaling controls the polytubey block in Arabidopsis" by Qu Lijia's Laboratory o
-
GNP2 encodes highly specific proline permeability in Candida albicans
Time of Update: 2022-02-16
Candida albicansHas multiple mechanisms of utilization, such as secreted proteases, oligopeptide transporters, and amino acid permeability (AAPs), exceeding the capabilities of non-pathogenic fungi (19–21) genes required for uptake of these nutrients are often induced under conditions associated with virulence, such as antagonism with macrophages or neutrophils (twenty two,twenty three) Amino acids are not only ready-made building blocks for protein biosynthesis, but are also valuable nitrogen and carbon sources that are heavily metabolized during energy production and gluconeogenesis .
-
Fat Injections Can Treat Common Cause of Foot Pain - Plantar Fasciitis
Time of Update: 2022-02-16
In a preliminary study published in the journal Plastic and Reconstructive Surgery, a couple-led team found that the fat injection procedure improved symptoms of plantar fasciitis in patients, setting the stage for a larger clinical trial foundation .
-
The unexpected appeal of RNA and lipids
Time of Update: 2022-02-16
In a new study published in the journal PNAS, Tomasz Czerniak and James Sáenz found that lipids can directly regulate the activity of RNA in a simple synthetic system .
Original search: Tomasz Czerniak, James Sáenz: Lipid membranes modulate the activity of RNA through sequence-dependent interactions.
-
Qiu Jinlong's team developed a new method for genome editing of plant pathogens based on endogenous CRISPR system
Time of Update: 2022-01-27
Recently, Qiu Jinlong's team from the Institute of Microbiology, Chinese Academy of Sciences has established an efficient genome editing method using the endogenous CRISPR-Cas system of the rice bacterial blight to achieve precise genetic modification of the bacterial blight.
This efficient genome editing method can facilitate plant immunity research using rice-bacterial blight as a model system .
-
Zhou Xi's research group from Wuhan Institute of Virology/State Key Laboratory of Virology reveals drugs with broad-spectrum antiviral effects in insects
Time of Update: 2022-01-27
In 2019, a collaborative study by Zhou Xi's team from the Wuhan Institute of Virology found that the small molecule drug enoxacin can enhance RNAi antiviral responses in human neural precursor cells and brain organoids, and protect against Zika virus infection and microcephaly.
-
Dong Xiuzhu's team from the Institute of Microbiology discovered the mechanism of transcription termination in archaea
Time of Update: 2022-01-27
Post-transcriptional regulation of somatic protein synthesis and assembly (Nucleic Acids Res, 2017); found that mRNA processing is important for low temperature adaptation in Methanogens (Environ Microbiol, 2021), and revealed the working mechanism of related nucleases (RNA Biol 2020; Mol Microbiol, 2017); discovered the first archaeal cold shock protein and its RNA chaperone function (PLoS Genet, 2019; Front Microbiol, 2017) .
-
Peking University researchers map pan-cancer single-cell map of tumor-infiltrating T cells
Time of Update: 2022-01-27
Combining gene expression profiles and T cell receptor sequences to study the heterogeneity and dynamics of tumor-infiltrating T cells, systematically compare T cells across different cancer types .
-
Tongji University and other places issued a paper: A new method for non-invasive screening of cervical lesions with cross-modal fusion
Time of Update: 2022-01-27
Recently, associate researcher Xia Wei of Suzhou Institute of Biomedical Engineering Technology, Chinese Academy of Sciences proposed a new method for non-invasive screening of cervical lesions by cross-modal fusion of cytology examination, HPV detection and colposcopy image examination results (as shown in Figure 1).
-
Meng Songdong's team has made new progress in the study of autoimmune disease treatment
Time of Update: 2022-01-27
This study clarified the mechanism of gp96 -mediated Treg activation, verified that activated Treg can effectively inhibit autoantibodies and Th cell-induced autoimmune diseases, and provided a basis for the development of drugs for the treatment of autoimmune diseases by activating Treg .
-
Pan Kaifeng's team clarified the effectiveness of gastroscopic screening and the optimal time interval for repeated screening through prospective studies
Time of Update: 2022-01-27
Based on the gastroscopic screening cohort of the National Upper Gastrointestinal Cancer Early Diagnosis and Early Treatment Project in Linqu, Shandong Province, this study not only conclusively verified the effectiveness of upper gastrointestinal endoscopy screening in real-world situations, but also provided a basis for optimizing endoscopy.
-
Lei Zuhai's research group and Zhang Fan's group from the Department of Chemistry have made progress in the field of near-infrared second region in vivo biosensing
Time of Update: 2022-01-27
png" cropright="13141f"> Figure 1 Design strategy, response mechanism, spectral changes before and after response, and in vivo sensing imaging of dual-activation probe PN910 Recently, young researcher Lei Zuhai and Professor Zhang Fan created a series of new NIR-II fluorescent dyes Chrodol by replacing the symmetric structure similar to rhodamine in the CX series of dyes with an asymmetric structure similar to Rhodol .
-
The research group of researcher Ye Ji from the School of Physics and collaborators reveal the magnetic behavior of the few-layer manganese antimony tellurium
Time of Update: 2022-01-27
Therefore, in the two-dimensional limit, revealing the magnetic states of ferromagnetic and antiferromagnetic MnBi 2 Te 4 materials in the parameter space of layer number, temperature, and external magnetic field is of great significance for further research on their topological properties .
-
Fudan University EMBO Journal publishes an article revealing a new mechanism of intestinal epithelial barrier dysfunction in inflammatory bowel disease
Time of Update: 2022-01-27
The study revealed that OMV is internalized into early endosomes in human intestinal epithelial cells, and then induces SNX10-mediated recruitment of caspase-5 and PIKfyve to the early endosomal membrane, which subsequently triggers the release of LPS into the cytoplasm and is caspase-5 perception .
-
eLife: Common osteoporosis drug boosts immune response in lungs
Time of Update: 2022-01-26
"Bisphosphonates are a safe and effective treatment for osteoporosis and have been standard of care to prevent bone loss and reduce the risk of fractures since the 1990s," said senior author Professor Mike Rogers, senior author of the study.
-
O-glycan sialylation defines breast cancer stem cell population
Time of Update: 2022-01-26
SummaryWe investigated a hypothesis that specific glycans can be used to differentiate breast cancer stem cells (CSCs) and affect their function .
Comparing CSCs and non-CSCs from multiple breast cancer models, it was found that CSCs differed by the expression of α2,3 sialylated core2o-linked glycans .
-
"Cell Stem Cell" is a new breakthrough in changing the paradigm!
Time of Update: 2022-01-26
"Li-Huei Tsai, senior author of the study, said the finding that neural precursor cells (NPCs) have senescent features, a finding that develops into major cells in the brain, including neurons, is remarkable and novel , but the group's extensive work to elucidate the underlying mechanism of the effects of abnormal chromosome number, or rather, asphericity, within the nucleus .
-
The research group of Associate Professor Xiao Yuling and Professor Hong Xuechuan has made new progress in the research of polypyridine ruthenium(Ⅱ) targeted therapy in the near-infrared second region
Time of Update: 2022-01-26
Recently, Journal of Medicinal Chemistry , a well-known journal in the field of medicinal chemistry under the American Chemical Society, published online the team of Associate Professor Xiao Yuling and Professor Hong Xuechuan of the State Key Laboratory of Virology and the School of Pharmacy in the Near Infrared Region II ( NIR-II , 1000-1700 nm ) The latest progress in single-molecule targeted therapy research .
-
Chen Chang's research group reveals the role of GAPDH nitrosylation in senile sarcopenia
Time of Update: 2022-01-26
On January 3, 2022, Chen Chang's research group from the Institute of Biophysics, Chinese Academy of Sciences published an online article entitled "GAPDH S-nitrosation contributes to age-related sarcopenia through mediating apoptosis" in the journal " Nitric Oxide ".
