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Sarcopenia is a disease that progressively reduces the strength and quality of skeletal muscle with aging, and has become a major public health problem for the elderly in modern society
.
The main pathogenic factors of the disease include the ubiquitin-proteasome pathway-mediated muscle protein degradation and skeletal muscle cell apoptosis
.
The research team found for the first time that the nitrosylation level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is increased in the skeletal muscle of naturally aging mice; when GAPDH is nitrosylated, it is transferred to the nucleus, thereby inducing pro-apoptosis The gene p53 upregulates the high expression of apoptosis regulator ( PUMA ), which mediates the apoptosis of skeletal muscle cells
.
GAPDH (Cys150, Cys154, Cys245) nitrosation sites during skeletal muscle aging were identified by quantitative protein nitrosation modification omics analysis.
After mutation of these three sites, the level of GAPDH nitrosation decreased, and skeletal muscle cells Apoptosis is reduced
Researcher Chen Chang from the Institute of Biophysics, Chinese Academy of Sciences is the corresponding author of this paper
.
Doctoral student Xie Ting, assistant researcher Qiao Xinhua and assistant researcher Sun Chuanxin are the co-first authors of the paper
.
Figure: GAPDH nitrosylation leads to senile sarcopenia by mediating apoptosis
Article link: https://
(Contributed by: Chen Chang's research group)
