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Platelet-mimicking procoagulant nanoparticles enhance hemostasis in an animal model of hemorrhage
Time of Update: 2022-02-16
SummaryThe use of donor-derived platelet transfusions for the treatment of bleeding disorders presents logistical challenges due to their limited availability, high risk of contamination, and short shelf life (5 to 7 days) .
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Surprising discovery: Non-mutated apolipoprotein E is also linked to dementia
Time of Update: 2022-02-16
As expected, some proteins previously associated with neurodegenerative diseases, including Tau (associated with neurofibrillary tangles), Aβ (associated with amyloid plaques), and α-Synuclein (associated with amyloid plaques), were found in the brains of dementia patients.
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Defective BRCA gene linked to prostate and pancreatic cancer
Time of Update: 2022-02-16
Based on these data, the researchers estimated that men with a mutation in the BRCA2 gene had a 27 percent risk of developing prostate cancer at age 80, more than double the risk of non-carriers .
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Gene therapy for Huntington's disease
Time of Update: 2022-02-16
Image: The field's first peer-reviewed journal, providing comprehensive access to key pillars of human gene therapy: research, methods and clinical applications .
An adeno-associated virus (AAV) gene therapy comprising a primary artificial microRNA (pri-amiRNA) targeting HTT mRNA is described in the peer-reviewed journal Human Gene Therapy .
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Zhang Lei/Tang Chao's team builds a computational model of the early developmental morphology of nematode embryos
Time of Update: 2022-02-16
Based on the above phase field model, the research team focused on how the cell division direction, division time, and viscosity relationship affect the embryonic morphological evolution path .
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Peking University research team released a new method of watching 3D cartoons to treat children with amblyopia
Time of Update: 2022-02-16
To address the challenges of traditional occlusion and compulsive eye therapy, the research team devised a treatment protocol for amblyopia using an asynchronous stimulation modality (3D movie/cartoon visual stimulation) .
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Study finds how genetic variation alters how brain stimulation affects memory
Time of Update: 2022-02-16
The conclusions suggest that people with the BDNF gene variant Val/Val are more likely to have altered cognitive activity through transcranial magnetic stimulation (TMS) .
Now, a paper reveals that changes in cognitive activity through transcranial magnetic stimulation (TMS) are more likely for people with the BDNF gene variant Val/Val .
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Stem cell discovery has potential to improve cancer treatment
Time of Update: 2022-02-16
Chute and his colleagues found that when mice received radiation therapy, cells lining the blood vessels in the bone marrow produced a protein called semaphorin 3A .
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Genome editing technology builds biological "valve" in DNA to directly form cellular information flow
Time of Update: 2022-02-16
Senior author Dr Thomas Gorochowski, University of Bristol Royal Society Research Fellow, said: "Similar to the valves that control the speed of fluids through pipes, these valves determine the flow of molecular processes in DNA .
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Gender differences in brain genes
Time of Update: 2022-02-16
)"In these four tiny brain structures, it was completely surprising to find that the activity levels of hundreds of genes depended solely on a woman's cycle phase," said Shah, who has devoted his career to understanding how sex hormones regulate typical sexual behavior .
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mBio discovers new way to attack herpes virus
Time of Update: 2022-02-16
Studies have shown that targeting two metal ion-dependent enzymes of human herpesvirus with two compounds, AK-157 and AK-166, can inhibit viral replication .
In test-tube studies, the researchers tested a series of compounds for their ability to inhibit specific metal-ion-dependent enzymes and replication of the herpes virus .
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Composition of gut microbiota may be associated with risk of long-term symptoms of SARS-CoV-2 infection
Time of Update: 2022-02-16
The composition of the gut microbiome may be linked to a person's risk of developing "long-term COVID" many months after initial infection with the SARS-CoV-2 virus that causes COVID-19 infection, according to a study published online in the journal Gut.
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Men with too much worry may develop heart disease and diabetes at a young age
Time of Update: 2022-02-16
To track the relationship between anxiety and cardiometabolic disease risk factors, the researchers analyzed data from participants in the Standard Aging Study .
After adjusting for demographic characteristics, higher levels of worry were associated with a 10% increased likelihood of having six or more cardiometabolic disease risk factors .
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Cell Rep: Targeting healthy cells could help develop treatments for pancreatic cancer
Time of Update: 2022-02-16
Image: Drs Angus Cameron and Dr Shinelle Menzes from the Bartz Cancer Institute Researchers at the Barts Cancer Institute, Queen Mary University of London, supported by a collaboration between the UK charities World Cancer Research and the Pancreatic Cancer Research Fund, have made a new discovery that sheds light on how healthy cells can help pancreatic tumors develop, and they hope This will help develop new drugs to treat this difficult-to-treat cancer .
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Line-scanning high-speed atomic force microscopy captures rapid displacement of single molecules
Time of Update: 2022-02-16
10 in the journal Nature Communications, describes a technique the researchers developed called line-scanning speed atomic force microscopy, It captures the movement of bacteriorhodopsin in response to light on a millisecond time scale .
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"Nature" cake becomes steak?
Time of Update: 2022-02-16
Dr Benoit Bruneau, director of the Gladstone Institute of Cardiovascular Disease and senior author of the new study, published in Nature, said: "This really challenges how cells maintain the process of becoming heart or brain cells once they start.
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Chinese scholars have made progress in the field of perovskite tandem solar cells
Time of Update: 2022-02-16
7%) of single-junction cells, in which the high surface defect density of narrow-bandgap perovskite grains and the short carrier diffusion length are constraints for tandem cells.
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Ultrasound technology predicts hip dysplasia in infants
Time of Update: 2022-02-16
Source: Radiological Society of North AmericaA technique that uses ultrasound images to determine the depth and shape of the hip socket can accurately predict which babies with hip dysplasia will develop normal hip structures and which ones will still develop, according to a study in the journal Radiology.
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PNAS: Hungry yeast are tiny living thermometers
Time of Update: 2022-02-16
"We asked: If these domains are important to a cell, then if we change the cell's environment - by growing them at different temperatures - the cell will 'care' and put energy into keeping the phase separated in the membrane ?""The answer is yes!"Past research has shown that when sugar is plentiful, a yeast cell's vacuole -- an important storage and signaling organelle -- grows so large that its membranes appear homogeneous under a microscope .
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Neuron Chen Lei's research group reported that intracellular calcium ions regulate TRPC3/6 channels..
Time of Update: 2022-02-16
On January 19, 2022, the research group of Chen Lei from the Joint Center for Life Sciences and the Institute of Molecular Medicine, School of Future Technology, Peking University, reported the structural mechanism of Ca2+ regulation of human TRPC3/6 and the pathogenic mechanism of FSGS-related mutants in the journal Neuron.
