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The researchers were surprised to find that APOE protein is strongly enriched in dementia, even in the brains of patients without the APOE ε4 allele
"Dementia is very complex, but you can simplify it: The disease is caused by a 'sticky protein' in the brain," says the Saunders-Brown Center on Aging and Department of Pathology, University of Lexington, Kentucky, USA.
The researchers used mass spectrometry to fully characterize the protein, or proteome, in the amygdala of 40 participants from the University of Kentucky Alzheimer's Disease Center autopsy cohort
As expected, some proteins previously associated with neurodegenerative diseases, including Tau (associated with neurofibrillary tangles), Aβ (associated with amyloid plaques), and α-Synuclein (associated with amyloid plaques), were found in the brains of dementia patients.
The data also revealed a strong relationship between the diagnosis of dementia and the detection of apolipoprotein E peptides in the brain
Dr Nelson said: "Our study furthers our understanding of multiple misfolded proteins in the human brain and advances the field by highlighting that ApoE may be a powerful contributor to the prototype of dementia, even when it does not lead to The same is true in individuals with the ApoE gene for disease
Magazine
American Journal of Pathology
DOI
10.
