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GNP2 encodes highly specific proline permeability in Candida albicans

 Last Update: 2022-02-16
 Source: Internet
 Author: User

Summary

close connection

Candida albicansTogether with the human host has driven the evolution of mechanisms that allow for metabolic flexibility

utilization of various nutrientsCandida albicanssuccessfully colonize and infect different host niches

is a common member of the human microbiome, colonizing mucosal surfaces such as the oral cavity, vagina, and gastrointestinal tract (1,2), despite a close symbiotic relationship, predisposing conditions such as long-term antibiotic treatment, immunosuppression, prolonged hospital stay, and disruption of anatomical barriers make the host susceptible to infectionC.

8–11) Nutrient composition of countless host nichesC.

C.
Candida albicansProline permeability, important for proline growth and filamentationin vitro.
despite the presence of additionalS.
wineProline permeates, they do not promote proline absorption
.
also,Gross National Product2Although the Δ strain had the ability to form filaments after phagocytosis, its ability to damage macrophages was impaired
.
Finally, deleteGross National Product2Sensitizes cells to oxidative stress, suggesting an important role for proline uptake in metabolism and stress adaptation in the host
.

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