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Cellular responses that protect pigs from COVID-19
Time of Update: 2022-02-18
Nelli and Gimenez-Lirola said their findings could lead to new ways to treat humans infected with COVID-19, the disease caused by infection with the SARS-CoV-2 virus .
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New drug for lung cancer: disease control rate as high as 92%
Time of Update: 2022-02-18
Experimental research, the results show [3]:• The objective response rate of non-small cell lung cancer patients can reach 55.
6%• The objective response rate of 11 patients with HER2-mutated non-small cell lung cancer was as high as 72.
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PLOS Digital Health: AI identifies individuals at risk for heart disease complications
Time of Update: 2022-02-18
"We can bring artificial intelligence to help refine the risk of virtually any medical diagnosis," said Martin Tristani-Firouzi, corresponding author of the medical study and a pediatric cardiologist at U of Health and Intermountain Children's Hospital, Nora and scientist Ike Harrison Cardiovascular Research and Training Institute .
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Want to know your "life span"?
Time of Update: 2022-02-18
In the current analysis, DunedinPACE accelerated in middle-aged and older adults with increased risk of chronic disease, disability, and mortality; across the lifespan, DunedinPACE correlated with biological age measures from blood chemistry and DNA methylation data and studies Participants' subjective perceptions of their own health .
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Cover article Chinese scientists find new tool to target cancer bone metastases
Time of Update: 2022-02-18
Through extensive testing, they found that engineering a "bone-homing" peptide and attaching it to a common breast cancer drug, the antibody trastuzumab, could effectively target and attack bone tumors .
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Pfizer's COVID-19 vaccine linked to increased risk of myocarditis
Time of Update: 2022-02-18
A case-control study found an increased relative risk of carditis associated with BNT162b2 (Pfizer) vaccination despite a low absolute risk .
Researchers at the University of Hong Kong studied 160 case patients (with myocarditis) and 1533 control patients (without myocarditis) to examine potential heart disease risks associated with vaccination with BNT162b2 .
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Salk Institute: Active ingredient in cannabis may fight brain aging
Time of Update: 2022-02-18
"We found that cannabidiol protects neurons from oxidative stress and cell death, two major causes of Alzheimer's disease," said senior author Pamela, research professor and director of the Salk Laboratory of Cellular Neurobiology La Maher said .
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Beijing Normal University scholars reveal the important potential of blood RNA modification in clinical detection of pulmonary arterial hypertension
Time of Update: 2022-02-18
More and more evidences suggest that RNA modification may be closely related to the occurrence and development of diseases, so we raise an important question: Can RNA modification be used as a biomarker for clinical diagnosis ?Pulmonary hypertension is a clinical pathophysiological state of excessive pulmonary arterial pressure, which can lead to right heart failure and has a high fatality rate .
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"Cells" 3D simulates the behavior of living "minimal cells"
Time of Update: 2022-02-18
"What's new is that we have developed a three-dimensional, fully dynamic minimal living cell dynamics model that simulates what happens in an actual cell," says Luthey Schulten .
" "We have developed a three-dimensional, fully dynamic kinetic model of the smallest living cell," said Luthey Schulten.
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Molecular mechanism of platelet aggregation regulation by Ero1α/PDI electron transport system on platelet surface
Time of Update: 2022-02-18
On January 20, 2022, the research group of Wang Zhizhen/Wang Lei from the Institute of Biophysics, Chinese Academy of Sciences published an article entitled "The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential" in " Redox Biology ", revealing for the first time The Ero1α/PDI electron transport system exists on the platelet surface, and the molecular mechanism of its regulation of platelet aggregation is elucidated .
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Obese people's 'lottery' genes
Time of Update: 2022-02-18
"Some people are more fortunate, and their genes mean higher amounts of fat under the skin, but lower levels of liver fat and a lower risk of diseases such as type 2 diabetes .
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A contagious cancer is spreading in clams
Time of Update: 2022-02-18
"The genetic similarities of cancer cells found in the Atlantic and Mediterranean clams suggest that human shipping activity may have spread cancer from one region to another," said co-first author Alicia Bruzos, who led the study on the study.
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The research group of Chen Lei from Future Institute of Technology reports the mechanism of intracellular calcium ion regulation of TRPC3/6 channels
Time of Update: 2022-02-18
On January 19, 2022, the research group of Chen Lei, Institute of Molecular Medicine, School of Future Technology, Peking University, Peking University-Tsinghua Life Science Joint Center , reported the structural mechanism of Ca 2+ regulation of human TRPC3/6 and FSGS-related mutations in Neuron .
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Cell Research: A new strategy for gene mutation therapy in glioma
Time of Update: 2022-02-18
The study gave Koschmann and his team a deeper understanding of how the atrx mutant works in glioma cells and how it interacts with a class of drugs known as ATM inhibitors .
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Cell: Typical sexual behavior in male and female mice guided by differences in brain gene activity
Time of Update: 2022-02-18
)"In these four tiny brain structures, it was completely surprising to find that the activity levels of hundreds of genes depended solely on a woman's cycle phase," said Shah, who has devoted his career to understanding how sex hormones regulate typical sexual behavior .
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"Cell" sub-issue: fatal blow!
Time of Update: 2022-02-18
The existing weight loss guidelines also mention that when adults lose weight, they need to consume 500-600 kcal per day.
In fact, the heavier the person, the more energy compensation, the more difficult it is to lose weight through exercise .
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Interbacterial transfer of carbapenem resistance and large antibiotic resistance islands through natural transformation of pathogenic Acinetobacter
Time of Update: 2022-02-18
Although genomic analysis of clinical strains suggests that homologous recombination plays an important role in the acquisition of antibiotic resistance genes, the underlying mechanism of horizontal gene transfer remains speculative .
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Chen Chang's team and Wang Zhizhen/Wang Lei's team work together to reveal that endoplasmic reticulum reduction stress accelerates aging
Time of Update: 2022-02-18
The Chen Chang group and Wang Zhizhen/Wang Lei group of the Institute of Biophysics, Chinese Academy of Sciences published an article entitled "ER Reductive stress caused by Ero1α S-nitrosation accelerates senescence" in the journal " Free Radical Biology & Medicine " on January 13, 2022 , revealing that A novel mechanism by which endoplasmic reticulum reducing stress accelerates aging .
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Sleep's ultimate meaning is repairing neuronal DNA damage
Time of Update: 2022-02-18
The related findings were published in the journal Nature Communications, entitled "Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons.
" Original title:Sleep increases chromosome dynamics to enable reduction of accumulating DNA damage in single neurons.
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Need for a clearer distinction between GMOs and genome-edited organisms
Time of Update: 2022-02-18
Researchers at Hokkaido University have proposed a framework to help differentiate GMOs from genome-edited organisms, taking into account scientific and social ethical considerations .
