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Interbacterial transfer of carbapenem resistance and large antibiotic resistance islands through natural transformation of pathogenic Acinetobacter

 Last Update: 2022-02-18
 Source: Internet
 Author: User

Summary

Acinetobacter baumannii

Infection is a major health threat, with treatment failure due to antibiotic resistance, especially carbapenems

Acinetobacter baumanniiis a multidrug-resistant pathogen that makes hospital-acquired infections difficult to treat

is a Gram-negative bacterium that causes widespread infection in humans and animals (1,2) This multidrug-resistant (MDR) agent poses a health threat, especially in intensive care units, where it can lead to bacteremia and ventilator-associated pneumonia

AcinetobacterWe provide evidence that natural transformation is the major transfer pathway and facilitates the onset of recombination events and the acquisition of multiple resistance genes carried by large genomic islands
.
Our experimental results are replicated inA.
BowmanyChromosomes and dynamics suggested to play a major role in natural transformationA.
Bowmanygenome
.

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