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Molecular mechanism of platelet aggregation regulation by Ero1α/PDI electron transport system on platelet surface

 Last Update: 2022-02-18
 Source: Internet
 Author: User

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Platelets are the second most abundant blood component, and their main physiological function is to sense blood vessel damage, adhere and aggregate at the wound, seal the wound and prevent blood loss

PDI is a key molecule in the endoplasmic reticulum that catalyzes the correct formation of disulfide bonds during the synthesis of nascent peptide chains

On January 20, 2022, the research group of Wang Zhizhen/Wang Lei from the Institute of Biophysics, Chinese Academy of Sciences published an article entitled "The extracellular Ero1α/PDI electron transport system regulates platelet function by increasing glutathione reduction potential" in " Redox Biology ", revealing for the first time The Ero1α/PDI electron transport system exists on the platelet surface, and the molecular mechanism of its regulation of platelet aggregation is elucidated

We found that oxidized but not reduced PDI promoted platelet integrin αIIbβ3-mediated platelet aggregation and adhesion

Researcher Wang Lei and Dr.

Figure: Molecular mechanism of Ero1α/PDI electron transport system on platelet surface regulating platelet aggregation

Article link: https://

(Contributed by Wang Zhizhen/Wang Lei Research Group)

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