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78.7% of patients with Ascendis’ investigational therapy achieved the primary endpoint of Phase 3 clinical trials
Time of Update: 2022-04-28
On March 15, Ascendis Pharma announced that its investigational therapy, TransCon PTH, received positive top-line data from the randomized, double-blind, placebo-controlled portion of a Phase 3 clinical trial in adult patients with hypoparathyroidism (HP) .
Retrieved March 14, 2022, from https:// 2022/03/13/2402193/0/en/Ascendis-Pharma-AS-Announces-Phase-3-PaTHway-Trial-of-TransCon-PTH-in-Adults-with-Hypoparathyroidism-Met-Primary-and-All- Key-Secondary-Endpoints.
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A new study suggests that regrowing tropical forests may have shorter lifespans
Time of Update: 2022-04-28
"Our results underscore the dual challenge of forest conservation in the tropics, that we not only need to restore degraded areas, but we also need to ensure that these young persistently regenerate forests," said Jean Paul Metzger, professor of ecology at the University of São Paulo and the project Co-authors of the new study .
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The team of Professor Xia Ningshao of our hospital published the research results related to pseudorabies virus in the journal Nature Communications
Time of Update: 2022-04-28
On March 22 , 2022 , the team of Professor Xia Ningshao of our school published a research paper titled "Structures of pseudorabies virus capsids" in "Nature Communications", a sub - journal of " Natu
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A series of progress has been made in the evolution of polyploid plants
Time of Update: 2022-04-28
Associate researcher Han Tingshen of the Biogeography and Ecology Research Group of the Banna Botanical Garden, together with his collaborators , summed up three hypotheses to verify whether polyploidy has achieved evolutionary success on the basis of previous work ( Figure 1 ) , namely the diversification hypothesis, The Long Survival Hypothesis and the Adaptive Hypothesis .
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Bayer Submits Indication Expansion Application for Feneridone in Patients with Early-Stage Chronic Kidney Disease and Type 2 Diabetes in the EU
Time of Update: 2022-04-28
On March 16, 2022, Bayer announced that it had submitted a Category II change application to the European Medicines Agency to seek to expand the indication of feneridone to cover patients with early-stage chronic kidney disease and type 2 diabetes .
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Bacteria on intertidal rockgrass in the North Atlantic
Time of Update: 2022-04-28
Principal investigators Susan Brawley (UMaine School of Marine Sciences) professors and Hilary Morrison, senior scientists at the Marine Biological Laboratory in Woods Hole, Massachusetts, at the National Science Foundation (NSF) ), he led a team of researchers to conduct a large-scale study of bacteria associated with the intertidal fucus Fucus vesiculosus .
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Professor Zhang Hongquan's team discovered a new mechanism to inhibit breast cancer metastasis
Time of Update: 2022-04-28
On March 21, 2022, Professor Zhang Hongquan's team from Peking University School of Basic Medicine published a long research paper titled "The DNMT1-PAS1- PH20 axis drives breast cancer growth and metastasis" in the journal Signal Transduction and Targeted Therapy.
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Long-term exposure to air pollution increases risk of autoimmune disease
Time of Update: 2022-04-28
Research published in the online edition of the open-access journal RMD open found that long-term exposure to air pollution was associated with an increased risk of autoimmune diseases, particularly rheumatoid arthritis, connective tissue and inflammatory bowel disease .
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Pivotal Phase 3 clinical results for innovative antibiotic combination Actively plan to submit NDAs this year
Time of Update: 2022-04-28
Venatorx has announced positive results from a pivotal Phase 3 clinical trial of its innovative antibiotic combination, cefepime/taniborbactam, in adult patients with complicated urinary tract infections, including acute pyelonephritis .
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Olapari reduces risk of death by 32% in selected early-stage breast cancer patients
Time of Update: 2022-04-28
Olaparib improved overall survival (OS) compared with placebo in this phase 3 trial as adjuvant therapy in patients with high-risk HER2-negative early breast cancer harboring germline BRCA mutations (gBRCAm).
com/news/lynparza-olaparib-reduced-risk-of-death-by-32-in-patients-with-germline-brca-mutated-her2-negative-high-risk-early-breast-cancer-in -phase-3-olympia-trial/(Original abridged)
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Marine life may adapt to climate change, but at a hidden cost
Time of Update: 2022-04-28
"If copepods or other organisms had to go down this adaptation path, with some genetic variation to respond to climate change, would they be able to tolerate some new environmental stress, other changes in the environment?" Pespeni wonders .
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The latest research results of the STD prevention and treatment team of the Dermatology Hospital are published in "PLoS Medicine"
Time of Update: 2022-04-28
Recently, the internationally renowned journal "PLoS Medicine" published a research paper online entitled "Expanding syphilis test uptake using rapid dual self-testing for syphilis and HIV among men
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Gut microbes predict survival in advanced non-small cell lung cancer, study finds
Time of Update: 2022-04-28
Recently, a research paper titled "Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer" published in Nat Med found that Akk could predict 12 Monthly Survival Rate!In the present study, we prospectively validated the predictive value of fecal Akk using metagenomics-based microbiome analysis in 338 patients with advanced NSCLC treated with first- or second-line ICIs .
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Chinese scholars and overseas collaborators have made progress in the research on the physical mechanism of organic photovoltaic devices
Time of Update: 2022-04-27
The active layer of organic photovoltaic (OPV) devices is usually composed of a "bulk heterojunction" formed by blending donor and acceptor materials, and achieves efficient exciton separation and charge transport through a nanophase-separated bicontinuous structure .
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South China Botanical Garden found that hydrogen water planting can increase the content of active ingredients in Wuzhi Mao peach
Time of Update: 2022-04-27
This study provides important clues and evidence for understanding the plant effect mechanism of hydrogen, and provides a theoretical basis for the application of hydrogen agriculture in Chinese herbal medicine cultivation .
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Significantly improved children's hereditary hypoglycemia, innovative monoclonal antibody reached the primary efficacy endpoint of Phase 2b clinical trial
Time of Update: 2022-04-27
Image source: Reference [2]In this multicenter, open-label, repeat-dose Phase 2b clinical trial, 23 patients with congenital HI who failed to adequately control hypoglycemia with standard therapy received RZ358 to evaluate the safety and tolerability of the drug , pharmacokinetics and glycemic efficacy .
Retrieved March 23, 2022, from https:// en/Rezolute-Announces-Positive-Results-from-the-Phase-2b-RIZE-Study-of-RZ358-in-Congenital-Hyperinsulinism.
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Chinese scholars have made progress in the research of sub-nanometer two-dimensional materials
Time of Update: 2022-04-27
Fig. 1 Schematic diagram of cluster alkene structure Two-dimensional layered materials represented by graphene exhibit remarkable electron delocalization behavior due to their unique intra-layer atomic connection, resulting in outstanding physical and chemical properties .
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Wang Xinxia's lab published a paper in BMC BIOLOGY
Time of Update: 2022-04-27
Title: DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO/m(6)A/DDIT4/PGC1 alpha signaling ( IF=8. 182 ) Authors: Chen, Wei; Chen, Yushi; Wu, Ruifan; Guo, Guanqun; Liu, Youhua; Zeng,
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Liu Chunming's research group was invited to write a review article in the Annual Review of Plant Biology...
Time of Update: 2022-04-27
This paper systematically summarizes the molecular regulation of endosperm development and storage material accumulation in cereal crops over the past 30 years, and analyzes the possible mechanisms of aleurone and starch endosperm differentiation, sugar transport and unloading during grain filling.
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Positive Early Clinical Results for Microbial Therapy/Keytruda Combination in Renal Cell Carcinoma
Time of Update: 2022-04-27
4D pharma plans to discuss with partners and the company's Genitourinary Cancer Advisory Board the next development path for MRx0518, which could lead to a potential pivotal clinical trial in patients with immune checkpoint inhibitor-refractory renal cell carcinoma .
