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Bayer's innovative combination therapy submits application for additional indications in Japan
Time of Update: 2022-04-29
Bayer has announced that it has submitted an additional indication application for the oral androgen receptor inhibitor (ARi) darolutamide to the Japanese Ministry of Health, Labour and Welfare (MHLW), seeking approval for darolutamide in combination with Docetaxel and androgen deprivation therapy (ADT) in patients with prostate cancer with distant metastases .
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Natural gas flaring may be source of respiratory disease
Time of Update: 2022-04-29
73% increase in hospitalizations"North Dakota's shale boom happened too quickly and the region was too far from other oil drilling sites," said Wesley Blundell, an assistant professor in Washington State University's School of Economic Sciences and the study's lead author.
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Genes & Devel: Uncovering Novel Links Between Circadian Clocks and Muscle Repair
Time of Update: 2022-04-29
March 6, 2022 / Bio Valley BIOON / -- The process of tissue regeneration is carried out in a developmentally timed manner, but the role of circadian rhythms is poorly understood by researchers; recent
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Science: Study reveals mechanism of spindle spindle instability in human oocytes
Time of Update: 2022-04-29
Recently, a research team from the Max Planck Institute in Germany published an article entitled "Mechanism of spindle pole organization and instability in human oocytes" in "Science" and found that the lack of the molecular motor KIFC1 (kinesin superfamily protein C1) would Causes instability of the human oocyte spindle .
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Nature: Uncovering the mechanism of bacterial rescue molecule SmrB to clear ribosome collision
Time of Update: 2022-04-29
"Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria" are described March 9, 2022 in the journal Nature by Beckmann, Green and a team of scientists in her lab led by Allen Buskirk .
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Nature Methods: Scientists use spatially resolved isotope tracing to reveal tissue metabolic activity
Time of Update: 2022-04-29
The related paper was recently published in the journal "Nature Methods", entitled: Spatially resolved isotope tracing reveals tissue metabolic activity .
The researchers combined stable isotope-labeled nutrient infusion with matrix-assisted laser desorption ionization imaging mass spectrometry (iso-imaging) to quantify metabolic activity in mammalian tissues in a spatially resolved manner .
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Global Phase 3 Clinical Trial Results Show Nirsevimab Significantly Protects Infants Against Respiratory Syncytial Virus Infection
Time of Update: 2022-04-29
On March 3, 2022, the international authoritative medical journal "New England Journal of Medicine" today published the detailed results of the phase III clinical trial of the prophylactic monoclonal antibody nirsevimab, which is the first single injection to treat all infants throughout the respiratory tract.
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Insecticides labeled with fluorescein
Time of Update: 2022-04-28
At the heart of the technology is a new method of enzymatically synthesizing analogs of luciferin, the substance that makes fireflies glow .
The researchers, led by Pimchai Chaiyen, began a new enzymatic cascade for the synthesis of luciferin analogs from phenolic compounds, which they called the HELP reaction .
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Bleeding rate reduced by 84%, hemophilia A gene therapy phase 3 clinical results listed on NEJM
Time of Update: 2022-04-28
On March 18, BioMarin Pharmaceutical announced that the results of the Phase 3 clinical trial of the gene therapy valoctocogene roxaparvovec for the treatment of severe hemophilia A were published in the prestigious medical journal The New England Journal of Medicine .
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Weili Medical's exclusive agent product Class III medical device registration certificate was renewed and approved
Time of Update: 2022-04-28
On March 17, Weili Medical announced that the company's exclusive agency product Class III medical device registration certificate has been approved by NMPA recently .
Sterilized by ethylene oxide, single use .
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Combination of DNA methyltransferase inhibitor decitabine and PAS1-30nt-RNA inhibits breast cancer growth
Time of Update: 2022-04-28
On March 21 , 2022 , Professor Zhang Hongquan's team from Peking University School of Basic Medicine published a long research paper titled "The DNMT1-PAS1- PH20 axis drives breast cancer growth and metastasis" in the journal Signal Transduction and Targeted Therapy .
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Sansheng Pharmaceutical's long-acting erythropoietin SSS06 project phase III clinical trial completed the first subject enrollment
Time of Update: 2022-04-28
SHENYANG, March 16, 2022 /PRNewswire/ -- Today, 3SBio announced that the recombinant erythropoiesis-stimulating protein injection (rESP, CHO cell) (drug code: SSS06), developed by 3SBio, is currently
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The amyloid hypothesis of Alzheimer's disease: New treatments bring new insights
Time of Update: 2022-04-28
Based on these studies, the therapeutic hypothesis for Aβ-targeted therapy is that if the levels of soluble Aβ and/or amyloid plaques in the brain are reduced to non-pathogenic levels—that is, to levels that do not promote the expansion of tau pathology, That can bring clinical benefits .
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Roche's oral therapy Evrysdi shows positive long-term results in patients with SMA
Time of Update: 2022-04-28
In addition, Genentech announced updated interim data from a Phase 2 clinical trial in infants with SMA younger than two months who had not yet developed symptoms, demonstrating the safety and efficacy of Evrysdi in this patient population .
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The first!
Time of Update: 2022-04-28
OlympiA trial results have shown that, The identification of BRCA1/2 mutations in women with high-risk disease gives them an additional option for treatment with olaparib, which reduces the risk of recurrence and improves survival in these breast cancer patients .
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Exposure to lead during pregnancy is actually related to having boys and girls?
Time of Update: 2022-04-28
A new study led by scientists at Tohoku University Graduate School of Medicine in Japan shows that higher levels of lead in a mother's blood are associated with greater odds of having male offspring .
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Novartis' latest clinical results of SMA gene therapy announced to improve multiple indicators in children
Time of Update: 2022-04-28
Results of a phase 3 clinical trial showed that children with 3 copies of the SMN2 gene and treated prior to symptom onset achieved age-appropriate motor milestones, including standing and walking, without ventilation or feeding tube support, and without severe, Treatment-related adverse events .
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Outstanding progress has been made in Lianhua Qingwen series research on the prevention and treatment of new coronary pneumonia
Time of Update: 2022-04-28
Professor Jia Zhenhua from the State Key Laboratory of Collateral Disease Research and Innovative Traditional Chinese Medicine gave a report titled "Give full use of the advantages of traditional Chinese medicine to play a greater role in the prevention and control of the Omicron epidemic" .
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Medicago truncatula MtGSTF7 can be activated by the transcription factor LAP1 to specifically participate in the accumulation of anthocyanins
Time of Update: 2022-04-28
Dixon's team from the University of North Texas, published an article online in the Journal of Experimental Botany entitled MtGSTF7, activated by the MYB transcription factor LAP1, A research paper specifically participates in anthocyanin accumulation in Medicago truncatula , which revealed a different regulatory mechanism of anthocyanin and procyanidin accumulation in Medicago truncatula from that in Arabidopsis .
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Positive Phase 2 Clinical Results of Muscular Dystrophy Therapy Start Phase 3 Clinical Trial This Year
Time of Update: 2022-04-28
Data observed after 90 and 180 days of treatment indicated:Participants had an average 43% increase in the ratio of glycosylated αDG to total αDG from baseline, suggesting that oral therapy has the potential to address the underlying causes of LGMD2i and promote functional improvements in patients .
