Genes & Devel: Uncovering Novel Links Between Circadian Clocks and Muscle Repair

March 6, 2022 / Bio Valley BIOON / -- The process of tissue regeneration is carried out in a developmentally timed manner, but the role of circadian rhythms is poorly understood by researchers; recently, an article published in the International In a research report titled "BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells" in the journal Genes & Development, scientists from Northwestern University Feinberg School of Medicine and other institutions discovered a new mechanism through research, which may Links circadian-controlled cellular metabolism and regeneration to muscle repair after injury

The circadian rhythm clock, the internal 24-hour clock in the body that regulates rest and wakefulness, is disturbed or associated with pathological manifestations of various metabolic diseases, including diabetes and obesity; Research is still scarce

Researcher Peek said Bmal1 controls the rhythm of gene expression, including those involved in regulating sleep, activity, hormones and metabolism

In addition, loss of Bmal1 impairs the response of muscle stem cells to the hypoxic state that occurs after injury, and loss of Bmal1 also leads to decreased levels of glycolysis, or the level of energy produced in cells

Image source: http://genesdev.

In this study, the researchers found that restoring the redox metabolite NAD+ into circadian clock-disturbed stem cells may restore normal cell proliferation and muscle fiber formation.

Taken together, our findings suggest that the researchers identified the muscle stem cell circadian clock as a key regulator of oxygen-dependent myoblast fate and muscle repair processes by controlling NAD+-driven injury responses

Original source:

Pei Zhu, Noah X.