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Nature Methods: Scientists use spatially resolved isotope tracing to reveal tissue metabolic activity

 Last Update: 2022-04-29
 Source: Internet
 Author: User

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Isotope tracing helps to determine the metabolic activity of organs, but methods to study metabolic heterogeneity within different organs are immature

The researchers combined stable isotope-labeled nutrient infusion with matrix-assisted laser desorption ionization imaging mass spectrometry (iso-imaging) to quantify metabolic activity in mammalian tissues in a spatially resolved manner

Taken together, this approach combines stable isotope injection with imaging mass spectrometry to quantitatively analyze metabolic activity in mammalian tissues with spatial resolution

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