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Combination of DNA methyltransferase inhibitor decitabine and PAS1-30nt-RNA inhibits breast cancer growth

 Last Update: 2022-04-28
 Source: Internet
 Author: User

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On March 21 , 2022 , Professor Zhang Hongquan's team from Peking University School of Basic Medicine published a long research paper titled "The DNMT1-PAS1- PH20 axis drives breast cancer growth and metastasis" in the journal Signal Transduction and Targeted Therapy .

Working model: The role and mechanism of DNMT1-PAS1-PH20 regulatory axis in breast tumor growth and metastasis.

The study found that DNA methyltransferase 1 (DNMT1) inhibits the transcription of PAS1 by binding and methylating the promoter of long non-coding RNA-PAS1 , and PAS1 inhibits breast cancer growth and metastasis .

Fu Yenan, a doctoral student at Peking University School of Basic Medicine, Zhang Qian, a master student, and Liu Xiao, an attending physician at Peking University Third Hospital, are the co-first authors of this article.

Original link: https://doi.

(Peking University School of Basic Medicine)

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