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mRNA-engineered CAR mononuclear cell therapy enters the clinical cell manufacturing process in just one day
Time of Update: 2022-08-15
html[1] Myeloid Therapeutics Doses First Patient with MT-101 in the IMAGINE Phase 1/2 Clinical Study, Marking the First-ever Dosing of an mRNA Engineered CAR Monocyte to Humans.
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The latest breakthrough progress of Jia Jinfeng's group from the School of Physics and Astronomy publishes PRL
Time of Update: 2022-08-15
Recently, the experimental team of Jia Jinfeng from the School of Physics and Astronomy of Shanghai Jiao Tong University cooperated with the research groups of Zhang Zhenyu and Cui Ping of the University of Science and Technology of China, and made breakthroughs in stanene materials, realizing topological edge states and superconductivity in multilayer stanene.
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Causes of multidrug resistance in tumor therapy
Time of Update: 2022-08-15
Original title:Oxidative stress-mediated up-regulation of ABC transporters in lung cancer cells Researchers from the Suzhou Institute of Biomedical Engineering Technology (SIBEBT) of the Chinese Academy of Sciences have revealed the reasons for the inevitable occurrence of multidrug resistance in the process of tumor treatment through long-term research on the mechanism of tumor multidrug resistance .
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A novel mechanism of inter-organ long-distance communication: lung tissue extracellular vesicles regulate the chemotactic recruitment of bone marrow neutrophils in response to pathogenic microorganisms
Time of Update: 2022-08-15
On May 20 , 2022 , Professor Yin Yuxin's team from Peking University School of Basic Medicine published a research paper titled " E xtracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation " in the Journal of Extracellular Vesicles .
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Boehringer Ingelheim develops novel therapy to delay lung function decline in patients with idiopathic pulmonary fibrosis
Time of Update: 2022-08-15
BI 1015550 is a novel phosphodiesterase 4B (PDE4B) inhibitor whose 12-week clinical trial data showed great potential to delay the rate of lung function decline in patients with idiopathic pulmonary fibrosis (IPF) .
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eLife: Scientists discover new clues to aging in mitochondria
Time of Update: 2022-08-15
Qingqing LiuCatherine E ChangAlexandra C WooldredgeBenjamin FongBrian K KennedyChuankai Zhou (2022) Tom70-based transcriptional regulation of mitochondrial biogenesis and aging eLife 11:e75658.
Qingqing LiuCatherine E ChangAlexandra C WooldredgeBenjamin FongBrian K KennedyChuankai Zhou (2022) Tom70-based transcriptional regulation of mitochondrial biogenesis and aging eLife 11:e75658.
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Professor Wan Shiqiang's doctoral student Zhang Jiajia published the latest research results in Global Change Biology, the flagship journal of global change - global change accelerates soil carbon emissions during the succession of abandoned farmland
Time of Update: 2022-08-15
On May 14, 2022, Professor Wan Shiqiang’s team officially published a paper entitled “Increased precipitation and nitrogen addition accelerate the temporal increase in soil respiration during The late
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FDA approves new oral therapy to delay functional decline of ALS by 33%
Time of Update: 2022-08-15
pdf On the 14th, Mitsubishi Tanabe Pharma America (MTPA) announced that the US FDA has approved oral edaravone (edaravone, English brand name Radicava ORS) for the treatment of amyotrophic lateral sclerosis (ALS) .
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Aging Cell: Molecular Mechanisms That Memories Are Vulnerable to Disruption After Aging
Time of Update: 2022-08-15
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Chengdu Institute of Biology has made new progress in the research on the evolutionary mechanism of animal multimodal communication
Time of Update: 2022-08-15
The researchers observed in the field that the species was often bitten by blood-sucking mosquitoes when it sang, and the defensive limb movements evoked by the mosquitoes were very similar to the reported dynamic visual signals of frogs ( Video 1 ) .
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The best way to increase the odds of identifying oncogenic mutations before tumor formation
Time of Update: 2022-08-15
"article titleOptimal pathways control fixation of multiple mutations during cancer initiation Pictured: A new paper from the Rice University lab shows how to increase the odds of identifying cancer-causing mutations before tumors form .
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Humanized yeast: Scientists create yeast with important human genes
Time of Update: 2022-08-15
Daran-Lapujade's lab has introduced a trait in yeast cells that is regulated by a collection of 10 genes that humans cannot live without; they carry the blueprint for a process called a metabolic pathway, which Breaks down sugar to harvest energy and create cellular building blocks within muscle cells .
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Fragile X protein regulates hippocampal GABA-A receptors
Time of Update: 2022-08-15
. In the work published in Cell Reports , Dr. Vitaly Klyachko, professor of cell biology and physiology at the University of Washington School of Medicine, said: "It is thought that because the fragile X chromosome is associated with the loss of a single protein, it is a simple disease , we can understand and fix quickly .
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Cell: Discovery of the first chaperone family to load zinc on client metalloproteins
Time of Update: 2022-08-15
The University conducts biochemical studies to characterize the interaction of ZNG1 and METAP1 leading to the activation of client proteins In addition to the yeast two-hybrid screen, where the team used ZNG1's human, mouse, and zebrafish homologs as "bait" to identify client METAP1, Skaar's team also collaborated with co-corresponding senior author David Giedroc, Ph. D.
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Expanded genomic testing aims to benefit children and young adults with cancer
Time of Update: 2022-08-15
Memorial Sloan-Kettering Cancer Center (MSK) researchers published new findings today in the journal Nature Communications, reporting results using a comprehensive sequencing approach in 114 children, adolescents and young adult patients with solid tumors .
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New progress in the contribution of root/hyphal pathways in alpine forests to soil organic carbon accumulation under nitrogen deposition in Chengdu Biological Institute
Time of Update: 2022-08-15
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Junshi Bio-Toripalimab combined with chemotherapy for first-line treatment of esophageal squamous cell carcinoma was approved by the State Drug Administration
Time of Update: 2022-08-15
SHANGHAI, May 16, 2022 /PRNewswire/ -- On May 16, 2022, Junshi Bio announced that the company's self-developed anti-PD-1 monoclonal antibody Toripalimab Injection (Tuoyi® ) in combination with paclitaxel and cisplatin for the first-line treatment of patients with unresectable locally advanced/recurrent or distant metastatic esophageal squamous cell carcinoma (ESCC) was approved by the National Medical Products Administration (NMPA) .
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What kind of sparks can occur when protein degradation meets antibody coupling?
Time of Update: 2022-08-15
1039/d2cs00141a Degrader-antibody conjugates (DACs) are a new molecular pattern that couples targeted protein degraders and monoclonal antibodies through certain chemical linkers .
1039/d2cs00141a Degrader-antibody conjugates (DACs) are a new molecular pattern that couples targeted protein degraders and monoclonal antibodies through certain chemical linkers .
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Nature: What tells cells that blood lipid levels are low, triggering a cascade of activity to prevent starvation?
Time of Update: 2022-08-15
Dr Peter Douglas (right) and graduate student Abigail WatsonResearchers at the University of Texas Southwestern have discovered a molecular pathway that allows cells to sense when their lipid supply is depleted, triggering a cascade of activity to prevent starvation .
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The latest research results of Professor Liu Zhonghua's research group from the School of Life Sciences of Hunan Normal University are published in Nature Communications
Time of Update: 2022-08-15
(Correspondent Li Yunlong) On May 8, Nature Communications, a sub-journal of Nature and the SCI-TOP journal, reported online that the research group of Professor Liu Zhonghua of the National and Local Joint Engineering Laboratory for Animal Peptide Drug Creation of the School of Life Sciences of our school and the Cooperative research paper Spider venom-derived peptide induces hyperalgesia in Nav1.
