Fragile X protein regulates hippocampal GABA-A receptors

Fragile X syndrome (FXS) is the most common inherited intellectual disabili.

Fragile X proteins regulate neuronal function, including those in the GABAergic system, which regulates the activity of neural circui.

Now, researchers have identified a previously unknown role for the Fragile X protein in the GABAergic syst.

These findings suggest that the role of the fragile X protein is far more complex than previously thought, and that finding effective treatments may depend on a more nuanced understanding of the many ways that loss of this protein affects the bra.

In the work published in Cell Reports , .

The GABAergic system is based on the transmission of gamma aminobutyric acid (GABA) from one neuron to anoth.

To better understand the role of Fragile X in the GABAergic system, Klyachko and Pan-Yue Deng, associate professor of cell biology and physiology at Washington University School of Medicine, studied mouse brain neurons with and without Fragil.

The researchers found that Fragile X protein regulates the single-channel activity of GABA AR in dentate granule cells _, and this interaction regulates tonic inhibition and excitability in these cel.

"The fragile X protein interacts directly with receptors that play an important role in the way neurons process information," Klyachko sa.

But Klyachko cautions against assuming that these findings can be easily translated into treatments for people with fragile X syndro.

"I think there's a very strong desire, an understandable desire, to immediately translate every discovery into a clinical trial," Klyachko sa.

FMRP regulates GABAA receptor channel activity to control signal integration in hippocampal granule cells