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Dr Peter Douglas (right) and graduate student Abigail Watson
Researchers at the University of Texas Southwestern have discovered a molecular pathway that allows cells to sense when their lipid supply is depleted, triggering a cascade of activity to prevent starvati.
"Lipids are key to providing energy and are building blocks of cell membranes and other cellular structures," said study leader Peter Douglas, .
.
Components in the SREBP pathway accomplish this function by directly binding sterol molecul.
In search of a mechanism by which cells may be universally adapted to sense lipid levels, the researchers starved Caenorhabditis elega.
The researchers found that when.
Further experiments showed that this release was triggered by a lack of a lipid called geranylgeranyl pyrophospha.
He added that previous research from other labs has shown that components of this pathway are active in many diseases and health problems, including metabolic disease, cardiovascular disease, viral infections, neuroaging and some cance.
Original title:
Intracellular lipid surveillance by small G protein geranylgeranylation
