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"Mermaids" help find multiple sclerosis medications
Time of Update: 2022-10-02
”Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs Both zebrafish and humans have GPR17 receptors.
”Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs Both zebrafish and humans have GPR17 receptors.
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Science Immunology: Defects in macrophage development lead to lung disease
Time of Update: 2022-10-02
essayC/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages Alveoli are tiny bubble-like air sacs located at the end of the bronchi.
essayC/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages Alveoli are tiny bubble-like air sacs located at the end of the bronchi.
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NAR: Spatiotemporal map of the occurrence of flower organs
Time of Update: 2022-10-02
The development of flower organs has a complex molecular regulation mechanism, and genes exercise specific and precise functions in different tissues and developmental stages, which regulate a series of processes such as the initiation, identity determination, morphogenesis and maturity of flower primordia groups.
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Identify potential biomarkers to distinguish between two aggressive brain tumors in children
Time of Update: 2022-10-02
Perera and other researchers found that an lncRNA gene called SPRIGHTLY was highly expressed in 4 constituent neural tube cell tumors, but not in group 3.
Perera and other researchers found that an lncRNA gene called SPRIGHTLY was highly expressed in 4 constituent neural tube cell tumors, but not in group 3.
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A temporary structure of the tumor was discovered
Time of Update: 2022-10-02
Scientists have demonstrated how tumor cells can evade immunotherapy by producing unique, temporary intercellular structures in which internal cells remain intact and can return to a single tumor cell.
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Cell: The role of a new neural pathway in the brain
Time of Update: 2022-10-02
In their study, they noted that neural pathways directly from the thalamus to the hypothalamus play an important role in processing touch information, using parathyroxine 2 neuropeptide (PTH2) as a neurotransmitter.
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Newly discovered prion therapeutic target
Time of Update: 2022-10-02
"Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein Prion diseases, such as bovine spongiform encephalopathy ("mad cow disease"), are deadly neurodegenerative infectious diseases that affect humans and other mammals and there is currently no cure.
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Newly discovered small molecules can disrupt the amyloid tangles that cause Alzheimer's disease
Time of Update: 2022-10-02
Using a molecule found in green tea, UCLA scientists have discovered other molecules that break down protein tangles in the brain that are thought to cause Alzheimer's disease and similar diseases.
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Five years after the water crisis, one in five residents of the city of Flint, Michigan, has PTSD
Time of Update: 2022-10-02
Aaron Reuben, a Duke University postdoc who led the study, said, "The largest public works environmental disaster in the United States apparently continues to place a mental health burden on many adults in Flint.
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How does Parkinson's spread in the brain?
Time of Update: 2022-10-02
"Our findings also suggest that lysosomal exocytosis may be a general mechanism for processing neuronal aggregation and anti-degrading proteins in normal, healthy environments and neurodegenerative diseases," said the study's senior author, Dr. Manu Sharma, who is an assistant professor of neuroscience at the Fellowes Family Institute of Brain and Mind at the Weill Cornell School of Medicine and the Alzheimer's Institute of Diseases in Appell.
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Chinese scholars have made progress in the study of container transportation scheduling for port logistics
Time of Update: 2022-10-02
The new approach proposed by the institute can help reduce the number of orders that logistics companies can optimize the path of their transport vehicles in the context of some complex operational activities, thereby reducing transportation costs and the number of orders delayed 。 The results were published in the INFORMS Journal on Applied in June 2022 under the title "Container Transportation Scheduling Between Port Yards and the Hinterland in Yunfeng.
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The "Pore-C" new technology understands the structure of the tissues within the nucleus and reprograms the cells
Time of Update: 2022-10-02
Rajapakse and collaborators tested the technique on several types of cells, revealing what the researchers call self-sustaining transcriptional clusters, a subset of proteins that play a key role in maintaining cellular properties.
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Liu Guangwei's research group of the School of Life Sciences published a new mechanism of tumor immunity for the mechanical force receptor PIEZO1: regulating dendritic cell-dependent T cell differentiation at eLife
Time of Update: 2022-10-02
Tumors are important diseases that threaten human health, and cellular immunotherapy is bringing new hope to anti-tumor immunotherapy. In immune cell antitumor therapy, CD4+ T cells can differentiate
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New findings from the Nature subjournal reveal how Parkinson's disease spreads in the brain
Time of Update: 2022-10-02
"Our findings also suggest that lysosomal exocytosis may be a general mechanism for processing aggregated and anti-degrading proteins from neurons — in normal, healthy environments and neurodegenerative diseases," said Dr. Manu Sharma, the study's senior author, who is an assistant professor of neuroscience at the Fellsfield Family Institute of Weill Cornell School of Medicine and the Alzheimer's Institute for Diseases in Alzheimer's Disease.
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South China Botanical Garden reveals the effects of canopy and understory nitrogen addition on nitrogen budget in South Asian tropical monsoon evergreen broad-leaved forests
Time of Update: 2022-10-02
The Research Group on Vegetation and Landscape Ecology of South China Botanical Garden, Chinese Academy of Sciences, systematically evaluated the effects of canopy and understory nitrogen addition on the nitrogen budget of the ecosystem of South Asian tropical monsoon evergreen broad-leaved forests based on the field experimental platform of "canopy and understory simulation nitrogen sedimentation" in Shimentai Nature Reserve, Yingde City, Guangdong Province.
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Nature's new study answers the controversy: embryonic blood cells are not dependent on stem cells
Time of Update: 2022-10-02
essayIndependent origins of fetal liver hematopoietic stem and progenitor cells Figure: (Left) In the Standard Model, hematopoietic progenitor cells are produced from hematopoietic stem cells.
essayIndependent origins of fetal liver hematopoietic stem and progenitor cells
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The Aquatic Institute and others reveal the effects of land use, hydrology and climatic factors on the water quality of the main stream of the Yangtze River from the landscape scale
Time of Update: 2022-10-02
Figure 6 Interpretation rate of the influence of environmental factors on the spatial pattern of water quality in the middle and lower reaches of the Yangtze River from 2017 to 2018 (a) the abundant water period and (b) the dry water period Consistent with previous findings (Xiong et al.
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How the memory of fear is trapped in the brain
Time of Update: 2022-10-02
Riccardo Barchiesi and Estelle Barbier have discovered a biological mechanism that increases the intensity of fear memory stored in the brain.
Riccardo Barchiesi and Estelle Barbier have discovered a biological mechanism that increases the intensity of fear memory stored in the brain.
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Cornell University: Explaining the key to chemotherapy resistance in cancer and its solutions
Time of Update: 2022-10-02
"This is another way to prove that slowing and bifurcation reversals are prevented by DNA-PKcs inhibitors, and it seems like a good way to control chemotherapy resistance," Smolka said.
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The Mo Fanyang Research Group of the School of Materials Science and Engineering has made progress in conducting cross-cutting research on AI for Science
Time of Update: 2022-10-02
Mo Fanyang's research group of the School of Materials Science and Engineering built a robot platform, developed the automation technology of TLC analysis, obtained a large amount of standardized TLC data, and then applied machine learning to regression analysis of the data to obtain a model that can make accurate predictions.
