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Metabolomic analysis reveals a key weakness in neuroblastoma: dependence on fatty acids for survival
Time of Update: 2022-10-02
”MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma The researchers were able to reduce the growth of MYCN-amplified tumors.
”MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma The researchers were able to reduce the growth of MYCN-amplified tumors.
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Dai Yakang's team at Suzhou Medical Institute made progress in the research of auxiliary diagnosis of brain diseases
Time of Update: 2022-10-02
104047), and the main work is completed by master's student Zhang Yu. Figure 3 Block diagram of an enhanced classification method for brain diseases based on course learning and feature representation On the autism spectrum disorder dataset (ABIDE) and Parkinson's disease dataset (PPMI), the proposed method has excellent classification performance compared with the existing one, indicating that enhanced feature expression and optimized sample distribution help improve the auxiliary diagnostic effect of brain diseases.
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The researchers believe that the "senile" interferon response in older patients leads to severe COVID-19
Time of Update: 2022-10-02
”Impaired immune response drives age-dependent severity of COVID-19 5 days after infection, the SARS-CoV-2 antigen (brown stain) was dispersed in the lung tissue of the aged mice, leading to severe illness and death.
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Shanghai Jiaotong University Yudelin team reviewed the research progress of biosynthesis of natural products of polyepoxy anthrone
Time of Update: 2022-10-02
1039/d2np00046f Author: Faculty of Life Science and Technology Feeds: Faculty of Life Science and Technology Recently, Professor Delin team of Shanghai Jiao Tong University was invited to publish a review article entitled "Chemistry and biosynthesis of bacterial polycyclic xanthone natural products" in Natural Product Reports, an authoritative journal in the field of natural products.
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New Findings in Gene Regulation: DNA Modifications Are Important for the Silencing of Endogenous Retroviruses
Time of Update: 2022-10-02
This finding provides an important basis for studying the role of abnormally activated ERVs in diseases such as cancer and autoimmunity.
This finding provides an important basis for studying the role of abnormally activated ERVs in diseases such as cancer and autoimmunity.
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Shen Qi's research group of Shanghai Jiaotong University has made important new progress in the study of tumor immune metabolism regulation
Time of Update: 2022-10-02
In order to further improve the effect of anti-tumor immunotherapy based on DCs, Shen Qi's research group of Shanghai Jiao Tong University School of Pharmacy recently focused on the cholesterol metabolism regulation mechanism of DCs, and innovatively designed a nano-delivery system to provide new strategies for tumor treatment.
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Shanghai Jiaotong University issued a document: Childhood exposure to triclosan may affect the physical development of 7-year-old children
Time of Update: 2022-10-02
Repeated measurement of the relationship between TCS exposure and physical development at age 7 years of age in childhood (n = 206)After sex stratification, the relationship between TCS exposure and physical development at age 7 years was repeatedly measured in childhoodPrevious studies have focused on the effects of single-point TCS exposure, and few studies have explored trends in TCS exposure levels and susceptibility windows based on longitudinal monitoring data at multiple time points.
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New progress has been made in the theoretical study of behavioral evolution
Time of Update: 2022-10-02
8;font-family:;font-size:12pt;} The monograph "Behavioral Evolution: From Animal Instinct to Human Civilization", independently completed by researcher Tang Yezhong of the Animal Behavior and Biomimicry Project Group, was recently published by Science Press.
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Nature Chemical Biology: How Stressful Tumor Cells Escape Cell Death
Time of Update: 2022-10-02
1038/s41589-022-01145-w When free radicals get out of control and disrupt protective cell membranes in a chain reaction, cells die of iron death (Ferroptosis).
1038/s41589-022-01145-w When free radicals get out of control and disrupt protective cell membranes in a chain reaction, cells die of iron death (Ferroptosis).
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Cell: Start with the intestinal flora to understand multiple sclerosis
Time of Update: 2022-10-02
”Source text searchGut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course The International Multiple Sclerosis Microbiome Research (iMSMS) consortium recently published an article in the journal Cell that the gut microbiome composition of patients with multiple sclerosis varies depending on the course of the disease and treatment.
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PNAS How much DNA damage can a cancer cell withstand?
Time of Update: 2022-10-02
"The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restricted A new study led by Claus M.
"The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restricted A new study led by Claus M.
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PNAS Cover: How the Brain Develops Cognition
Time of Update: 2022-10-02
The findings highlight two fundamental mechanisms for the multi-level development of cognitive abilities in biological neural networks:The apparent evolution of synapses is Hebbian learning at the local scale and reinforcement learning at the global scale;as well as the self-organization dynamics through the spontaneous activity and balance of the excitation/inhibition ratio of neurons.
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The secret of anemone eternal youth
Time of Update: 2022-10-02
Single-cell transcriptomics identifies conserved regulators of neuroglandular lineages Cross-sectional of transgenic anemone tentacles showing differentiation products of SoxC cell populations (magenta) and lead muscle groups (yellow).
Single-cell transcriptomics identifies conserved regulators of neuroglandular lineages Cross-sectional of transgenic anemone tentacles showing differentiation products of SoxC cell populations (magenta) and lead muscle groups (yellow).
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The mysterious soil virus gene was first discovered
Time of Update: 2022-10-02
Jansson, chief scientist and co-author of the Department of Energy's Pacific Northwest National Laboratory (PNNL), said the detailed atomic structure is unprecedented and reveals for the first time the potential mechanisms by which the new enzyme could play an important role in soil ecology.
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Nature Aging: Longer lifespans come from faulty RNA processing
Time of Update: 2022-10-02
”essayDecreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity Pictured: Cascaryotic Caenorhabditis elegans is an important model organism in aging research.
”essayDecreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity Pictured: Cascaryotic Caenorhabditis elegans is an important model organism in aging research.
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Cancer Cell: A potential combination therapy for deadly brain cancer
Time of Update: 2022-10-02
" "We show here that three drugs with a wide range of characteristics that are already in clinical use can be newly combined to lift the immunosuppressive barrier of tumors and induce a therapeutic immune response, significantly extending the survival time of a GBM mouse model that has so far evaded all the treatments used to treat it.
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Cell: The role of a new neural pathway in the brain
Time of Update: 2022-10-02
In their study, they noted that neural pathways directly from the thalamus to the hypothalamus play an important role in processing touch information, using parathyroxine 2 neuropeptide (PTH2) as a neurotransmitter.
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Five years after the water crisis, one in five residents of the city of Flint, Michigan, has PTSD
Time of Update: 2022-10-02
Aaron Reuben, a Duke University postdoc who led the study, said, "The largest public works environmental disaster in the United States apparently continues to place a mental health burden on many adults in Flint.
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Science Immunology: Defects in macrophage development lead to lung disease
Time of Update: 2022-10-02
essayC/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages Alveoli are tiny bubble-like air sacs located at the end of the bronchi.
essayC/EBPβ regulates lipid metabolism and Pparg isoform 2 expression in alveolar macrophages Alveoli are tiny bubble-like air sacs located at the end of the bronchi.
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Liu Mofang was invited to publish a long review of piRNA in Nature Reviews Molecular Cell Biology
Time of Update: 2022-10-02
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