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JAMA Neurol: It is recommended to use recombinant t-PA thrombolysis before mechanical thrombus removal in acute stroke
Time of Update: 2021-03-21
This measurement showed that even though the collateral blood flow was completely blocked during embolization, rt-PA can still reach the ischemic blood vessel, and its concentration is similar to the systemic level.
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JAHA: Comparison of transient ischemic attack and new-onset atrial fibrillation after ischemic stroke
Time of Update: 2021-03-21
Newly Diagnosed Atrial Fibrillation After Transient Ischemic Attack Versus Minor Ischemic Stroke in the POINT Trial .
https:// target="_blank" rel="noopener">Newly Diagnosed Atrial Fibrillation After Transient Ischemic Attack Versus Minor Ischemic Stroke in the POINT Trial in this message
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BRAIN: 7T MRI to detect the long-term evolution of MS hoop lesions
Time of Update: 2021-03-21
Recent data indicate that there is a ring of iron-containing microglia around the white matter lesions of multiple sclerosis, which is called hoop lesions, which means that the patient's disease course is more serious and there is a tendency to develop progressive multiple sclerosis.
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JAMA Psychiatry: Anxiety, depression, suicide...the mental health of patients with Parkinson's disease is worthy of attention!
Time of Update: 2021-03-21
In addition to motor dysfunction, mental disorders such as depression and anxiety of varying degrees are also common, which affect the quality of life, daily functions and prognosis of patients, and have gradually attracted attention in recent years.
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Nat Neurosci: Different neural bases that mediate tissue damage and allodynia caused by depression-like states
Time of Update: 2021-03-21
The study showed that different thalamic cortical circuits PO Glu → S1 Glu and PF Glu → ACC GABA-Glu inhibited the ectopic pain associated with tissue damage and depression-like states, respectively, thereby providing insight into pathological pain caused by different etiologies.
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Brain Connectivity: Central structure-function connection mismatch after mild traumatic brain injury
Time of Update: 2021-03-21
Decoupling of structural and functional connectivity in hubs and cognitive impairment after mild traumatic brain injury .
Decoupling of structural and functional connectivity in hubs and cognitive impairment after mild traumatic brain injury in this message
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Stroke | The Light of Sinopharm: The third phase of TASTE trial led by Professor Wang Yongjun's team in Temple of Heaven brings new hope to stroke patients!
Time of Update: 2021-03-21
Overall, compared with the edaravone group, the edaravone dexcamphanol group had a significantly higher proportion of patients with good functional outcomes (mRankin≤1) on the 90th day of stroke (67.
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JAMA: The effect of ventral vs dorsal surgical approach on postoperative physical function of patients with cervical spondylotic myelopathy
Time of Update: 2021-03-21
48% and 24% of patients with cervical spondylotic myelopathy who require cervical spine surgery, the ventral and dorsal surgical approaches have no significant effect on the patient’s body function at 1 year after surgery, but the dorsal surgical approach is complicated Significantly lower risk of disease.
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Eat more fruits and vegetables containing VC/VE, which may prevent Parkinson's disease!
Time of Update: 2021-03-21
▲ The influence of other factors Generally speaking, this large cohort study of the Swedish population shows that higher dietary intake of vitamin E and vitamin C is associated with a lower risk of Parkinson's disease.
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Behavioural Brain Research: Analysis of fear suppression and fear elimination in obstructive sleep apnea (OSA) among veterans: the significance of co-morbidity with post-traumatic stress disorder (PTSD)
Time of Update: 2021-03-21
It is assumed that patients with obstructive sleep apnea syndrome show better ability to suppress and eliminate fear after CPAP treatment, which is at least partly due to improved sleep quality and better memory consolidation.
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Cell Death Differ: ARRB1 and ARRB2 show opposite functions in microglia-mediated inflammation and Parkinson's disease
Time of Update: 2021-03-21
Related schematicsAll in all, the results of this study show that two closely related ARRBs play opposite functions in microglia-mediated inflammation and the pathogenesis of PD, and these functions are partly mediated by Nprl3.
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Lancet Neurology: The relationship between asymptomatic carotid artery stenosis and stroke risk: a population-based cohort study, systematic review, and meta-analysis
Time of Update: 2021-03-21
Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.
The Lancet Neurology, Volume 20, Issue 3, 193-202 Risk of stroke in relation to degree of asymptomatic carotid stenosis: a population-based cohort study, systematic review, and meta-analysis.
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JAHA: What is the prevalence of intracranial aneurysms in patients with aortic disease?
Time of Update: 2021-03-21
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels published on the prestigious journal JAHA the areas of disease research article, the study aims to use nationally representative cohort sample data to assess the prevalence of AD in patients with IA and identify the potential risk factors of IA.
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Cell | Demystifying the mechanism by which antidepressants can "anti-depress"
Time of Update: 2021-03-21
Basically all ADs, including KET and R, R-HNK, increase brain-derived neurotrophic factor (BDNF) through neurotrophic tyrosine kinase receptor 2 (TRKB) Expression and signal transduction [1].
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Is the development of Alzheimer's disease therapy about to turn a corner? In-depth interpretation of Lilly in the study of antibody detailed results
Time of Update: 2021-03-21
▎The content team editor of WuXi AppTec last weekend, Eli Lilly and Company (Eli Lilly and Company) published in the "New England Journal of Medicine" the detailed results of its Phase 2 clinical trial of its Alzheimer's disease (AD) antibody therapy donanemab.
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Eli Lilly's donanemab treats Alzheimer's disease with mixed results
Time of Update: 2021-03-21
Recently, Eli Lilly shared more details of the highly anticipated Phase II TRAILBLAZER-ALZ trial, which tested the beta-amyloid-targeted antibody donanemab in early symptomatic Alzheimer’s disease Role in the patient.
The 18-month TRAILBLAZER-ALZ trial enrolled 272 patients with early symptomatic Alzheimer's disease between the ages of 60 and 85.
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Frontiers in Neuroscience: Let life become a butterfly!
Time of Update: 2021-03-21
Maguire, professor and chair of the Department of Psychiatry and Neuroscience, UCR School of Medicine, published an article titled Investigation of Risperidone Treatment Associated With Enhanced Brain Activity in Patients Who Stutter in Frontiers in Neuroscience, which combined functional neuroimaging It is found that “risperidone”, a drug previously designated for schizophrenia and bipolar disorder, may have a certain effect on stuttering, and its mechanism of action may be similar to that of the stellate in the striatum of the brain.
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Cerebral Cortex: The frontal control network predicts memory inhibition ability
Time of Update: 2021-03-21
permThe unique functional connection model of the frontal control network can predict the suppression-induced forgetting (SIF) score.
The unique functional connection model of the frontal control network can predict the suppression-induced forgetting (SIF) score.
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Wang Hongyan/Hu Jin/Wei Bin discover potential treatments for traumatic brain injury
Time of Update: 2021-03-21
iNature traumatic brain injury (TBI) is the leading cause of morbidity and death in young adults around the world. So far, clinical trials related to TBI treatment have proven frustrating. This may
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NEJM: Eli Lilly’s Phase II Aβ Antibody Clinical Results Announced: The primary endpoint was reached, the secondary endpoint was missed
Time of Update: 2021-03-21
Therefore, in patients with early Alzheimer's disease, the comprehensive score of cognition and activities of daily living in the Donanemab treatment group at 76 weeks was better than that of the placebo group, but the secondary results were uneven.
