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Behavioural Brain Research: Disruption of cortical-motor interaction in Parkinson's disease
Time of Update: 2021-03-21
The purpose of this article is to explore the relationship between EEG alpha and low/high-beta band power and exercise results in a padless finger tap task, and compare it between a group of Parkinson’s disease participants and a group of healthy controls These measurements.
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JAMA Netw Open: Collaborative care helps improve the prognosis of adolescents with persistent post-concussion syndrome (PPCS)
Time of Update: 2021-03-21
Recently, a study published in the journal JAMA Netw Open revealed that compared with conventional care, adolescent patients receiving collaborative care relieved their PPCS symptoms at 3 and 12 months and improved their quality of life.
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Alzheimer's Dementia: Blood AD biomarker concentration is related to pathology and clinical diagnosis
Time of Update: 2021-03-21
It was found that the AD biomarker concentration in blood is related to pathology and clinical diagnosis, and can predict the future development of clinical AD, providing evidence that can be included in multi-ethnic and community studies.
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Several international authoritative journals refocus on the gut-brain axis!
Time of Update: 2021-03-21
Big data studies confirm that enterobacteria capsules and colonoscopic enterobacteria transplantation have the most significant effects on disease intervention | Intestinal Jun Weekly Issue 152: A major study in a sub-publish of "Nature"!
How does intestinal bacteria transplantation colonization and treatment of disease effects are regulated by host immunity | Changjun Jun Weekly No.
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PNAS: Huashan Hospital's Liu Jie team discovered a new mechanism of neuroimmune regulation in the intestinal area
Time of Update: 2021-03-21
This study revealed a new mechanism by which the cholinergic nervous system in the enteric nervous system regulates immune cell function through the cholinergic neurotransmitter acetylcholine (ACh), and then participates in the occurrence and development of inflammatory bowel disease.
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Microbiome: Fecal bacteria transplantation promotes nerve function recovery
Time of Update: 2021-03-21
FMT can promote the functional recovery of mice with spinal cord injury, promote neuronal axon regeneration, improve animal body weight and metabolic characteristics, and enhance the integrity of the intestinal barrier and gastrointestinal motility.
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Brain Connectivity: Central structure-function connection mismatch after mild traumatic brain injury
Time of Update: 2021-03-21
Decoupling of structural and functional connectivity in hubs and cognitive impairment after mild traumatic brain injury .
Decoupling of structural and functional connectivity in hubs and cognitive impairment after mild traumatic brain injury in this message
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JAHA: What is the prevalence of intracranial aneurysms in patients with aortic disease?
Time of Update: 2021-03-21
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels published on the prestigious journal JAHA the areas of disease research article, the study aims to use nationally representative cohort sample data to assess the prevalence of AD in patients with IA and identify the potential risk factors of IA.
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Acta Neuropathologica: Huntington's disease brain-derived small RNA reproduces the main pathological features of Huntington's disease in young mice
Time of Update: 2021-03-21
In summary, the results of this study indicate that HD-sRNA derived from human putamen can trigger abnormal motor coordination in young mice and reproduce the main pathological features of HD.
1007/s00401-021-02272-9#Sec30" target="_blank" rel="noopener"> Huntington's disease brain-derived small RNAs recapitulate associated neuropathology in mice.
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Stroke: Original study by thousands of Chinese people: Serum complement C3 level can effectively predict the prognosis of ischemic stroke
Time of Update: 2021-03-21
Increased Serum Complement C3 Levels Are Associated With Adverse Clinical Outcomes After Ischemic Stroke.
Increased Serum Complement C3 Levels Are Associated With Adverse Clinical Outcomes After Ischemic Stroke.
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Lancet Sub-Journal: Safety and Effectiveness of Intensive Antihypertensive Therapy in Endovascular Therapy for Acute Stroke
Time of Update: 2021-03-21
Compared with the standard care systolic blood pressure target of 130-185 mmHg, the enhanced systolic blood pressure target of 100-129 mmHg after successful endovascular treatment does not reduce the rate of intracranial hemorrhage 24-36 h.
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Evrysdi treats spinal muscular atrophy (SMA), CHMP holds positive opinions
Time of Update: 2021-03-21
In FIREFISH, according to the Bayley scale's total exercise scale assessment, 29% (12/41) of infants treated with Evrysdi for 12 months were able to sit for at least five seconds without support.
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Neurology: A large intake of healthy plant-based diets may be directly related to a 10% reduction in the population risk of stroke
Time of Update: 2021-03-21
March 15th, 2021 // - Recently, in a research report published in the international journal Neurology , scientists from the Harvard Chen Zengxi School of Public Health and other institutions found through research that eating a healthy plant-based diet ( Including foods such as vegetables, whole grains and legumes), and reducing the intake of unhealthy foods (refined grains or added sugars) may reduce the risk of stroke by 10%.
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Lancet Neurol: Tau protein monoclonal antibody Tilavonemab has no effect on the treatment of progressive supranuclear palsy!
Time of Update: 2021-03-21
1016/S1474-4422(20)30489-0" target="_blank" rel="noopener">Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial .
1016/S1474-4422(20)30489-0" target="_blank" rel="noopener">Safety and efficacy of tilavonemab in progressive supranuclear palsy: a phase 2, randomised, placebo-controlled trial in this message
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Cell | More complicated than imagined, scientists reveal the complex biological mechanism of behavioral symptoms of neurodevelopmental disorders
Time of Update: 2021-03-21
) Did not show autism-like behavior disorder, but there was still hyperactivity, and the intestinal flora was no different from wild-type mice.
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Lancet Neurology: Longitudinal observation study of RT-QuIC in detecting cerebrospinal fluid α-synuclein in patients with rapid eye movement sleep behavior disorder
Time of Update: 2021-03-21
This technology can identify misfolded α-synuclein in the CSF of patients with Parkinson's disease and Lewy body dementia, with a sensitivity of 90-95% and a specificity of 80-100%.
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Brain: Neurofilament light chain protein, which can effectively predict the clinical prognosis of subarachnoid hemorrhage
Time of Update: 2021-03-21
Clinically, early brain injury can be assessed using the World Federation of Neurosurgical Societies (WFNS) score, which can also partially predict long-term neurological outcomes.
CSF and serum neurofilament light chain (NfL) increased after SAH.
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Nat Commun: POLRMT mutation damages mitochondrial transcription and induces neurological diseases
Time of Update: 2021-03-21
These common multi-organ diseases may be sporadic, or they may be caused by mitochondrial DNA (mtDNA) or genetic pathogenic mutations in about 1,200 nuclear coding genes related to mitochondrial function and maintenance.
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Understand NEJM in 2 minutes: risdiplam treats type 1 spinal muscular atrophy
Time of Update: 2021-03-21
[Editor's note] NEJM Quick Take introduces an article of the latest NEJM in 2 minutes in the form of animation. "NEJM Frontiers of Medicine" updates the video summary of the current NEJM treatises e
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GlaxoSmithKline's central nervous system treatment drug Rapidone approved for new indications for bipolar disorder
Time of Update: 2021-03-21
Shanghai, China, March 3, 2021-GlaxoSmithKline (hereinafter referred to as "GSK"), the world's leading multinational healthcare company, today announced that Rapidone (generic name: Lamotrigine Dispersible Tablets) has been awarded the National Medicines of China supervision and management Bureau of new indications approved for the control of adult patients with bipolar disorder or mood episode recurrence resurgence [1].
