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Acta Neuropathologica: Huntington's disease brain-derived small RNA reproduces the main pathological features of Huntington's disease in young mice

 Last Update: 2021-03-21
 Source: Internet
 Author: User

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Progressive motor changes and selective death of spinous neurons (MSNs) in the striatum are the main pathological features of Huntington's disease (HD), which is caused by the amplification of CAG trinucleotide repeats in the coding region of Huntington's (HTT) gene One of the neurodegenerative diseases is also an autosomal dominant hereditary neurodegenerative disease.

HD is a neurodegenerative disease caused by the amplification of CAG trinucleotide repeats in the coding region of Huntington (HTT) gene, and it is also an autosomal dominant neurodegenerative disease.

In this study, the researchers injected sRNA purified from the putamen of unaffected individuals (CTL-sRNA-PT) and HD patients (HD-sRNA-PT) into the striae of wild-type (WT) mice In vivo, and conduct comprehensive behavioral, biochemical and transcriptome analysis.

Importantly, the researchers found that specifically blocking sCAG only reduced the neurotoxicity of HD-sRNA-PT to a limited extent.

In summary, the results of this study indicate that HD-sRNA derived from human putamen can trigger abnormal motor coordination in young mice and reproduce the main pathological features of HD.

HD-sRNA derived from human putamen can trigger abnormal motor coordination in young mice and reproduce the main pathological features of HD.

Creus-Muncunill, J.
, Guisado-Corcoll, A.
, Venturi, V.
et al.
springer.
com/article/10.
1007/s00401-021-02272-9#Sec30" target="_blank" rel="noopener">Huntington's disease brain-derived small RNAs recapitulate associated neuropathology in mice.
springer.
com/article/10.
1007/s00401-021-02272-9#Sec30" target="_blank" rel="noopener"> Huntington's disease brain-derived small RNAs recapitulate associated neuropathology in mice.
Acta Neuropathol 141 , 565–584 (2021).
https://doi.
org/10.
1007/s00401-021-02272-9 Leave a message here springer.
com/article/10.
1007/s00401-021-02272-9#Sec30" target="_blank" rel="noopener">springer.
com/article/10.
1007/s00401-021-02272-9#Sec30" target="_blank" rel="noopener">

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