Stroke: Original study by thousands of Chinese people: Serum complement C3 level can effectively predict the prognosis of ischemic stroke

 

The complement system (Complement system), also known as the complement cascade, is an important part of the innate immune system.
It has the functions of protecting the host from microbial invasion, clearing immune complexes, and maintaining tissue balance.

immunity

In addition, the defense function of the complement system can also aggravate immune, inflammatory and degenerative reactions under various pathological conditions.
The complement system can be activated through three pathways (classical pathway, lectin pathway and alternative pathway) and is regulated by many soluble and membrane-bound complement regulatory proteins.

Complement C3, as the most abundant complement protein, is the convergence point of the three complement activation pathways and the main mediator of inflammatory response.
6 It has been reported that the activation of complement C3 plays a pivotal role in brain injury after cerebral ischemia and inhibits The activation of complement can reduce the volume of cerebral infarction.

Some clinical studies have shown that elevated levels of circulating complement C3 and medsci.
cn/course/search.
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels increase the risk of disease related to ischemic brain stroke after circulating complement C3 levels were significantly increased.
However, the effect of circulating complement C3 on the prognosis of ischemic stroke is still unclear.

Some clinical studies have shown that elevated levels of circulating complement C3 and medsci.
cn/course/search.
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels increase the risk of disease related to ischemic brain stroke after circulating complement C3 levels were significantly increased.
However, the effect of circulating complement C3 on the prognosis of ischemic stroke is still unclear.
Some clinical studies have shown that elevated levels of circulating complement C3 and medsci.
cn/course/search.
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels increase the risk of disease related to ischemic brain stroke after circulating complement C3 levels were significantly increased.
However, the effect of circulating complement C3 on the prognosis of ischemic stroke is still unclear.
medsci.
cn/course/search.
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">Heart vascular stroke

Accurate risk stratification in patients with ischemic stroke is of great significance for the rapid optimization of patient care and management , but existing traditional risk factors (such as hypertension, diabetes, and dyslipidemia) cannot fully explain the effects of ischemic stroke Poor prognosis.

Accurate risk stratification in patients with ischemic stroke is of great significance for the rapid optimization of patient care and management , but existing traditional risk factors (such as hypertension, diabetes, and dyslipidemia) cannot fully explain the effects of ischemic stroke Poor prognosis.
Accurate risk stratification in patients with ischemic stroke is of great significance for the rapid optimization of patient care and management , but existing traditional risk factors (such as hypertension, diabetes, and dyslipidemia) cannot fully explain the effects of ischemic stroke Poor prognosis.
Manage diabetes

Therefore, there is a need to identify new biomarkers that can improve the prediction of adverse clinical outcomes after ischemic stroke.

In this way, Pinni Yang of Soochow University and others based on CATIS (China Antihypertensive Trial in Acute Ischemic Stroke) prospectively studied the relationship between serum complement C3 and death, major disability and vascular events in a large cohort of patients with ischemic stroke.

.

The results showed that during the 3-month follow-up, 866 participants (25.

After multivariate adjustment, when the two extreme quantiles were compared, increased serum complement C3 levels were associated with increased risk of the primary outcome (OR 1.

The variable-adjusted Spline regression model showed that there was a linear relationship between serum complement C3 and the risk of primary outcome (Plinearity=0.

Original source

Yang, P.

Yang, P.
, Zhu, Z.
, Zang, Y.
, Bu, X.
, Xu, T.
, Zhong, C.
, .
.
.
& He, J.
(2021).
Increased Serum Complement C3 Levels Are Associated With Adverse Clinical Outcomes After Ischemic Stroke.
_Stroke_, STROKEAHA-120.
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