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The milestone of the "mini human brain": growing in a petri dish for 300 days, how similar is it to a real newborn brain?
Time of Update: 2021-03-24
However, a recent study published in Nature Neuroscience, a sub-Journal of Nature, revealed that when grown in a petri dish for a long enough time-250 to 300 days later, the cells in the mini-human brain appear and regenerate in terms of genetic characteristics.
24, 2021 from https:// -clusters-grown-lab-more-year-mirror-changes-newborn-s-brain[3] Maturation of'mini brain' organoids matches human brain development Retrieved Feb.
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Going up, a new posture of depression inheritance!
Time of Update: 2021-03-24
The highly enriched non-coding small RNAs in sperm can be used as a carrier of epigenetic information to inherit the phenotypic changes of the parent under environmental stimuli to the offspring.
This indicates that sperm RNA is the key carrier for passing the depressive phenotype from parent to offspring.
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What the? It may be true that playing video games can prevent depression
Time of Update: 2021-03-24
com/stemcell/" target="_blank">ips of adolescents' screen-based sedentary behaviour with depressive symptoms: the Millennium Cohort Study".
com/stemcell/" target="_blank">ipsThese findings show how different types of screen time have a positive or negative impact on the mental health of young people, and may have different effects on boys and girls.
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A fat really destroys all! What is the effect of obesity on the health of the body?
Time of Update: 2021-03-24
1003387A few days ago, in a research report titled "Duration of obesity exposure between ages 10 and 40 years and its relationship with cardiometabolic disease risk factors: A cohort study" published in the international journal PLoS Medicine, scientists from Loughborough University and other institutions Through research, we found that the longer duration of obesity in the body may be directly related to the lower the values of all cardiovascular and metabolic disease factors.
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Zhao Yan's group reveals that the pathogenic genes WDR45 and WDR45B of nervous system diseases regulate the maturation of neuronal autophagosomes
Time of Update: 2021-03-24
This study revealed that WDR45/45B functions in the late stage of autophagy in nerve cells, mediating the fusion process of autophagosomes and lysosomes, and promoting the formation of autophagolysosomes.
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Clinical Nutrition: Another blow for coffee lovers? Studies have shown that drinking lots of coffee increases the risk of heart disease!
Time of Update: 2021-03-24
com）,36257137-73,、（6）(CVD)。，，，，。，，Elina Hyppönen，，。Hyppönen:“，，，。”"In this study, we studied the genetic and phenotypic relationship between coffee intake and plasma lipids (cholesterol and fat in the blood)-and found causal evidence that habitual coffee consumption can cause adverse effects.
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PNAS interpretation! Chinese scientists are expected to develop new therapies to treat neurological diseases!
Time of Update: 2021-03-24
In the article, researchers found that SOX9 protein is an important regulator of choroid plexus function, which can ensure the correct composition of cerebrospinal fluid; related research results may help scientists understand the molecular regulation mechanism behind the blood-cerebrospinal fluid barrier, and No new therapeutic strategies for the prevention and treatment of neurodevelopmental disorders have been developed to lay a certain foundation.
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ACS Nano: Bringing new hope to the treatment of spinal cord injury, Tongji University's Cheng Liming team improved the immune microenvironment and remodeled neural circuits through nano-layered double hydroxide
Time of Update: 2021-03-24
Function (PPI) network diagram, in which transforming growth factor receptor 2 (TGFBR2) is highly related to the biological processes of nerve regeneration and immune regulation, and is a key gene for LDH to promote the repair of spinal cord injury.
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Scientists have cultivated mini brain organoids in the laboratory, which can mature like a baby's brain!
Time of Update: 2021-03-24
February 27, 2021 // - A few days ago, a research report titled "Long-term maturation of human cortical organoids matches key early postnatal transitions" was published in the international journal Nature Neuroscience , from the University of California and other institutions Scientists have cultivated a new type of mini brain organoid in the laboratory through research, which is as mature as a baby's brain.
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Nat Commun: Longevity gene FOXO3 protects neural stem cells in the brain from stress mechanisms
Time of Update: 2021-03-24
com" target="_blank">/---In a new study, researchers from the Weill Cornell Medical College in the United States discovered that a gene FOXO3 related to the prolonged lifespan of humans can protect the neural stem/progenitor cells in the brain (Neural stem/progenitor cell, NSPC) is protected from the harmful effects of stress.
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Nat Genet︱GWAS analysis reveals a new gene (new protein) that has a clear causal relationship with Alzheimer's disease
Time of Update: 2021-03-24
Then through Bayesian colocalization COLOC and Mendelian randomization (SMR) experiments, it was found that CTSH, DOC2A, ICA1L, LACTB, PLEKHA1, SNX32, STX4, ACE, CARHSP1, RTFDC1 and STX, these 11 genes are in cis It regulates the protein abundance in the brain and has obvious causal relationship with AD (Table 2).
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Wall collision warning | How does the brain rhythm bring us a sense of boundary?
Time of Update: 2021-03-24
For example, experiments that allow sitting people to navigate in a virtual environment show that when the human brain encodes position information close to the boundary, the theta oscillations generated by the medial temporal lobe will increase [6].
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Neuron | Jiang Youxing team reveals CNGA1 gating and ion selectivity mechanism
Time of Update: 2021-03-24
On March 1, 2021, Jiang Youxing’s research group from the University of Texas Southwestern Medical Center published an article Structural mechanisms of gating and selectivity of human rod CNGA1 channel in Neuron, analyzing the opening and closing of human CNGA1 homotetramers The three-dimensional structure of cryo-electron microscopy of the state reveals the gate position that is different from the classical voltage-gated ion channel.
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If the P2 or P3 segment of the posterior circulation of the brain is occluded, can thrombectomy be used?
Time of Update: 2021-03-23
Therefore, Lukas Meyer and other scholars from Germany conducted a study to explore the frequency and clinical and safety results of mechanical thrombectomy for isolated posterior circulation DMVO stroke, and compare it with the presence or absence of intravenous thrombolysis.
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Study on the influence of the structure of the inner surface groove of polymer nerve catheters on the growth of nerve cells
Time of Update: 2021-03-23
Adding a groove structure on the inner surface of the catheter can effectively guide the growth of nerve cells, thereby promoting the regeneration and functional repair of damaged nerves.
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PNAS | Shu Yousheng's team discovers a new strategy for neuromodulation
Time of Update: 2021-03-23
On March 1, 2021, PNAS, the research group of Shu Yousheng of the Institute of Transformation of Brain Science, Fudan University, published a paper titled: Nonthermal and reversible control of neuronal signaling and behavior by midinfrared stimulation, the first report on Midinfrared Stimulation (MIRS) It can be used as a new type of neuromodulation strategy.
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How mysterious is the placebo effect?
Time of Update: 2021-03-23
Image source: 123RF After a large-scale sample analysis, the researchers located the placebo effect to specific brain areas, such as thalamus.
Another brain area essential for early processing of pain information, the somatosensory cortex, is also affected by the placebo effect.
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Science: New study identifies the structure and dynamics of key receptors for migraines, paving the way for better treatments!
Time of Update: 2021-03-23
The relevant research results have been published in the recent Science journal under the title Structure and dynamics of the CGRP receptor in apo and peptide-bound forms.
abf7258">Structure and dynamics of the CGRP receptor in apo and peptide-bound forms, Science (2021).
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Nature | Are you hungry?
Time of Update: 2021-03-23
After the researchers light-activated AgRP neurons in Fed mice, they showed a preference for food smell similar to that of Fasted mice.
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In addition to liver cirrhosis, these reasons can also lead to hyperammonemic encephalopathy!
Time of Update: 2021-03-23
Cerebral edema, brain herniation, and seizures usually occur when acute hyperammonemia (that is, in the case of acute liver failure) results in arterial blood ammonia levels> 200 μmol/L.
