Study on the influence of the structure of the inner surface groove of polymer nerve catheters on the growth of nerve cells

Content Introduction Chinese Abstract: Nerve catheter is an effective method for repairing peripheral nerve injury.
Adding a groove structure on the inner surface of the catheter can effectively guide the growth of nerve cells, thereby promoting the regeneration and functional repair of damaged nerves.

Therefore, it is of great significance to explore the influence mechanism of the groove structure on the inner surface of the nerve conduit on the growth of nerve cells.

In this paper, PC12 cells and chicken forebrain cells were cultured on the substrates of grooves with different widths.
The results showed that chicken forebrain cells showed a tendency to grow freely across the grooves, while PC12 cells grew along the grooves and the width of the grooves increased.
The stronger the small growth orientation.

In response to this phenomenon, this paper constructs a three-dimensional physical model of nerve cell axons growing on the groove base, and uses the energy minimum method to systematically describe the growth and deformation of nerve cell axons on the three-dimensional groove base.

The simulation results show that the groove structure on the inner surface of the nerve conduit has a better growth guiding effect on the nerve cells with the larger the axon diameter or the greater the stiffness.

This article explores the mechanism of the groove structure on the growth of nerve cells, hoping to provide new support for improving the repair efficiency of nerve ducts to peripheral nerve injuries.

Keywords: trench duct, nerve cell growth, axon growth model, energy minimization method of: Deming, Suohai Rui Qian Jin, Yin Jun, FU Jian-zhong, Yong Huang: Zhejiang University, Hangzhou University of Electronic Science and Technology, University of Florida Cite this article: Zhang, D.
, Suo, H.
, Qian, J.
et al.
Physical understanding of axonal growth patterns on grooved substrates: groove ridge crossing versus longitudinal alignment.
Bio-des.
Manuf.
3, 348–360 (2020 ).
https://doi.
org/10.
1007/s42242-020-00089-1 full text link (click to download the PDF directly) http:// s42242-020-00089-1 Picture selection of the article Picture 1 The force of nerve cell axons on the groove base Picture 2 The application of the energy minimization method in the process of axons turning over the top of the groove Picture 3 The same groove base on PC12 cells and chicken Different growth guidance of forebrain cells (CFNs) Figure 4 The same groove on the growth guidance of nerve cells with different axon diameters or stiffness References: Swipe up to read 1.
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