A fat really destroys all! What is the effect of obesity on the health of the body?

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：The University of Sheffield

【1】bioon.

The findings of this article also highlight the potential impact of body weight in middle age on brain health in later life; researcher Annalena Venneri said that currently more than 50 million people worldwide suffer from Alzheimer’s disease, despite the fact that scientists have done dozens of Years’ research has also yielded certain research results, but at present, scientists around the world are still unable to effectively cure this cruel disease.

[2] bioon.

In recent years, the incidence of obesity and mental illness among young people has increased significantly.

[3] bioon.

Researchers said that a high-fat diet will reduce the number of CD8+ T cells and anti-tumor activity in tumors.

[4] bioon.

The researchers said that obese people may not all have the same risk of cardiovascular and metabolic risk factors.

[5] bioon.
com/article/6780091.
html">Interpretation of Science Sub-Journal! Uncover the mysterious connection between obesity and cancer metastasis!

doi: 10.
1126/sciadv.
abc3175

A few days ago, a research report titled "Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis" was published in the international journal Science Advances.
Scientists have revealed the link between obesity and cancer metastasis through research.
One in two men or one in three women will be diagnosed with cancer in their lifetime, but fortunately, scientists have made significant progress in the treatment of many types of cancer, especially when the cancer is limited to When in a small area, the researcher can remove the lesion through surgical resection or chemotherapy.

In some patients, tumor cells will break away from the primary lesion and invade other areas of the body.
This is the so-called cancer metastasis, which will induce extensive damage to the patient’s body and make treatment difficult.
In fact, 90% of the Cancer deaths are directly related to cancer metastasis.
The risk of cancer metastasis is particularly high in certain populations, including those who are obese.
The extent to which obesity affects black and Hispanic Americans in the United States seems to be greater than the general population.
At present, researchers do not know why obesity is higher.
Speed ​​induces cancer metastasis.

Image source: CC0 Public Domain

[6] bioon.
com/article/6777220.
html">Ann Int Med: Obesity may increase the risk of death for COVID-19 patients, especially young male patients

doi: 10.
7326/M20-3742

Recently, in a research report published in the international journal Annals of Internal Medicine, scientists from the Caesars Medical Institution in Southern California and other institutions found that there is a significant association between the risk of death of COVID-19 patients and their BMI.
And this association does not depend on obesity-related diseases and other potential interfering factors.
The results of this study show that there is a significant association between COVID-19 mortality and higher BMI values ​​in young patients and male patients, but there does not seem to be such an association in female patients and the elderly.

In this study, researchers analyzed the medical health records of more than 6,900 COVID-19 patients recruited from the health system of the Caesars Medical Institution in Southern California from February to May 2020 to determine obesity and deaths due to COVID-19 Researchers will adjust the risk of obesity based on common comorbidities, including diabetes, hypertension, heart failure, myocardial infarction, and chronic lung disease or kidney disease.
These diseases themselves are also poor prognosis for COVID-19 patients In addition, this study also took into account the time for patients to be tested for SARS-CoV-2.
They found that within 21 days after being diagnosed with COVID-19, the mortality rate of the higher-weight patient group was the normal-weight group The mortality rate of patients is 4 times.

[7] bioon.
com/article/6759028.
html">J Hepatol: Maternal obesity will increase the probability of liver cancer in the offspring, and it can accumulate for generations!

doi: 10.
1016/j.
jhep.
2020.
03.
050

Scientists recognize the link between obese mothers and liver cancer in the offspring of obese mothers, but the mechanism is still unclear.
In a new study published in the Journal of Hepatology, researchers found a microRNA in obese mother mice, which seems to transmit liver cancer susceptibility and increase the risk of liver cancer in offspring and offspring.

One third of the world's population is overweight or obese, and this global obesity epidemic is threatening human health.
Obesity increases the risk of metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
In the United States, up to 50% of HCC diagnosed recently are caused by liver metabolic disorders such as NAFLD.
Maternal obesity directly affects the health of offspring and plays a key role in obesity and metabolic diseases.
Epidemiological studies have shown that obesity is an independent risk factor for liver cancer.
This new study provides insights into whether and how maternal obesity affects tumor incidence in offspring.

[8] bioon.
com/article/6758879.
html">Int J Epidemiol: Obesity may be directly related to the increased risk of dementia in the population

doi: 10.
1093/ije/dyaa099

Recently, in a research report published in the International Journal of Epidemiology, scientists from University College London and other institutions found that obesity may be directly related to an individual’s increased risk of dementia 15 years later, and weight management It plays a key role in reducing the risk of dementia.
The results of this study show that obese individuals may face a 31% increased risk of dementia in later life compared to individuals with a body mass index (BMI) within the normal range, and women may have a higher risk of developing the disease.

Researcher Dr.
Dorina Cadar said that relevant research findings may provide the latest evidence that obesity has important application value for indicating the risk of dementia; the status of individual BMI and waist circumference may be monitored to effectively avoid the occurrence of abnormal metabolism.
Therefore, Researchers recommend that people adopt a healthy and balanced diet (such as the Mediterranean diet), appropriate physical exercise, and reduce alcohol intake throughout adulthood to reduce their body weight to a normal level.

[9] BMC Med: Sad.
.
.
BMJ sub-publishes: Obesity causes cancer, and men and women are different!

doi: 10.
1186/s12916-020-01855-9

In a new study published in "BMC Medicine", a research team led by the University of Bristol and the International Agency for Research on Cancer investigated the impact of different body fat measurement methods on the risk of colorectal cancer in men and women.
This large study involving more than 100,000 people found that a higher body mass index (BMI) is more risky for men; a higher waist-to-hip ratio (waist circumference divided by hip circumference, which measures belly fat) is more risky for women .

In this new study, the researchers analyzed the gender and body part-specific associations between obesity and colorectal cancer risk, and whether obesity-related metabolites can explain the association between obesity and colorectal cancer.
Using the genetic variation of 123 metabolites including BMI, waist-to-hip ratio, and targeted metabolomics as indicators, the researchers used Mendelian randomization to combine gender and waist-to-thigh ratios with colorectal cancer risk.
Gender-specific research.
The research subjects came from the data of 58221 patients and 67694 control participants in the Colorectal Cancer Genetics and Epidemiology Alliance, Colorectal Cancer Interdisciplinary Research and Colon Cancer Family Registry.

[10] Obes Rev: Obesity = aging! Research says: Obesity can lead to early onset of chronic diseases and shortened life expectancy

doi: 10.
1111/obr.
12991

An article published in "Obesity" magazine pointed out that obesity is a disease that accelerates aging, and obesity should be regarded as an aging disease.
According to the author, obesity and aging are "two sides of the same coin.
" Studies have shown that after the age of 40, obesity shortens the life expectancy of men by 5.
8 years and the life expectancy of women by 7.
1 years.
Obese patients also have other signs of aging, including shortening of the "clock of life" telomeres, systemic inflammation, and decline in organ function.

The author points out that the shortened life expectancy may be because obesity accelerates aging on multiple levels.
From a molecular level analysis, obesity not only damages the integrity of nuclear DNA and mitochondrial DNA, but also changes DNA methylation patterns, which are all related to the epigenetic aging of different tissues.
The author points out that both aging and obesity can lead to age-related diseases.
Aging and obesity form a vicious circle, which promotes the occurrence and development of age-related diseases.
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