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Alzheimer Dementia: To prevent cognitive decline and dementia, Beijing is on the move!
Time of Update: 2021-04-22
Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.
Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.
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JNNP: Clinically isolated syndrome, higher rates of death and disability in patients with brain atrophy
Time of Update: 2021-04-22
Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: a 30-year follow-up.
Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: a 30-year follow-up.
Linear brain atrophy measures in multiple sclerosis and clinically isolated syndromes: a 30-year follow-up.
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Nature: Early training can delay the occurrence of Rett syndrome
Time of Update: 2021-04-21
The authors found that in the mouse model of Rett syndrome, intensive training before the onset of symptoms can significantly improve the performance of specific exercise and memory tasks, and greatly delay the onset of symptoms.
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A mouse study may have discovered a drug to prevent Alzheimer's disease!
Time of Update: 2021-04-21
If we study the pathways that cause Alzheimer's disease, scientists have discovered that an enzyme called gamma secretase plays a key role in the process of converting APP into beta amyloid.
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[Science Sub-Journal] New breakthroughs in cell recombination programming | Cell therapy can help stroke patients repair their brains and is expected to restore 90% of their motor functions
Time of Update: 2021-04-21
They used "tissue nanotransfection technology (TNT)" to effectively reprogram skin cells to turn them into vascular cells, and then injected them into the brain of stroke mice to promote the formation of new blood vessels, restore normal blood supply, and repair Damaged brain tissue.
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Do not just think of spinal cord disease?
Time of Update: 2021-04-21
3 d left vertebral artery local stenosis; e the shaded area is the infarct area of this patient, involving the pain and temperature sensation of the chest, lumbar, and sacrum It is not uncommon to report the appearance of sensory planes in small lateral medullary infarcts of the conduction beam.
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Sci Rep: Research reveals biomarkers of adult neural stem cells
Time of Update: 2021-04-21
Although there are more and more tools available for studying NSC and neurogenesis in mouse models, one of the main obstacles to exploring this basic biological process in the human brain is the lack of specific NSCs suitable for advanced imaging and in vivo analysis Sign.
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MONEAD study: Is it safer for expectant mothers to choose these two anti-epileptic drugs? 丨AAN2021
Time of Update: 2021-04-21
➤The ratio of the maximum blood concentration of anti-epileptic drugs in the third trimester of pregnancy has no significant correlation with the general conceptual ability scores of children born to pregnant women with epilepsy after correction.
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There is a "zombie gene" in the human brain, and it becomes active only after death
Time of Update: 2021-04-21
The research was published in the journal "Scientific Reports" with the title "Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain".
These "zombie genes"-those genes whose expression increases in the post-mortem interval-are a characteristic of the cell.
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Mo Wei's team at Xiamen University discovered the key role of epigenetics in cerebellar morphogenesis
Time of Update: 2021-04-21
At the peak of cerebellar development (from P7 to P10), GC migration requires genes that are down-regulated in this time window and is completely inhibited by the Nfix-Setdb1 repressor complex.
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Biol Sex Differ: Supplementing DHA in the diet of pregnant women can counteract the mental health effects of the stress of pregnant women on male fetuses!
Time of Update: 2021-04-21
Related research was recently published in Biology of Sex Differences with the title Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress.
1186/s13293-020-00356-x">Maternal DHA supplementation influences sex-specific disruption of placental gene expression following early prenatal stress
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Li Huawei/Shu Yilai team developed CRISPR/Cas9 gene editing to prevent sensorineural hearing loss
Time of Update: 2021-04-21
On March 22, 2021, Professor Li Huawei from the Eye, Ear, Nose and Throat Hospital Affiliated to Fudan University and a research team from Shu Yilai published a research paper Prevention of acquired sensorineural hearing loss in mice by in vivo Htra2 gene editing in Genome Biology.
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Nature: Chen Li's team from Shandong University reveals the molecular mechanism of the "dawn phenomenon" of diabetes
Time of Update: 2021-04-21
On March 24, 2021, Professor Sun Zheng from Baylor College of Medicine and Professor Chen Li from Qilu Hospital of Shandong University, as co-corresponding authors, published a research paper titled: REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity in Nature.
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What is the best assessment method for acute stroke? Talk about your thoughts
Time of Update: 2021-04-21
This debate is not about the increasing number of endovascular treatments and the discussion of no large vessel occlusion, but to find a practical, effective, economical, and the best acute brain in community hospitals that can be implemented on a global scale.
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Intracranial hemorrhage, when should hemostatic agents be used? Who can use it?
Time of Update: 2021-04-21
1016/S0140-6736(18)31033-X] published in Lancet in 2018 is an international multi-center, placebo, randomized controlled Phase 3 clinical study that explores "intracranial hemorrhage patients" Whether tranexamic acid treatment in the hyperacute phase can reduce hematoma enlargement and improve patient prognosis", the main clinical outcome: 90-day neurological function (mRS).
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Commun Bio: Deep brain stimulation helps treat diseases
Time of Update: 2021-04-20
html">New discoveries of deep brain simulation put it on par with therapeutics Original source: Musa Ozturk, Ashwin Viswanathan, Sameer A.
html">New discoveries of deep brain simulation put it on par with therapeutics Original source: Musa Ozturk, Ashwin Viswanathan, Sameer A.
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Nature | Biological Clock and Dawn Phenomenon——The Circadian Regulation Mechanism of Insulin Sensitivity
Time of Update: 2021-04-20
On March 24, 2021, Professor Sun Zheng from Baylor College of Medicine and Professor Chen Li from Qilu Hospital of Shandong University jointly published a research paper entitled REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity in Nature, reporting on the hypothalamic optic chiasm The REV-ERB gene of GABA neurons in the nucleus (SCN) region controls the circadian rhythm of insulin suppression of liver gluconeogenesis.
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What to do with depression in patients with Alzheimer's disease?
Time of Update: 2021-04-20
The results of the study showed that compared with conventional care, there are 7 interventions that are related to significantly reducing the depressive symptoms of dementia patients, including: cognitive stimulation, cognitive stimulation combined with cholinesterase inhibitors, massage and touch therapy, multidisciplinary care, Occupational therapy, exercise combined with social and cognitive stimulation and recall therapy.
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Nat Hum Behav: New research links genes to the function of the human brain
Time of Update: 2021-04-20
This separation can be traced back to gene expression in specific cell types and molecular pathways, providing key insights for future research on mental illness.
This separation can be traced back to gene expression in specific cell types and molecular pathways, providing key insights for future research on mental illness.
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Nature | Xu Huaqiang/Zhang Yan/Jiang Yi collaborated to reveal the drug action of the neurotransmitter serotonin receptor and the molecular mechanism of phospholipid regulation
Time of Update: 2021-04-20
This work reveals how phospholipid PI4P (PtdIns4P) and cholesterol regulate receptor functions, and the molecular mechanism of how the drug Aripiprazole recognizes serotonin receptors.
