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March 25, 2021 //---According to the results of a new study, early training in the pre-symptomatic stage can help patients with Rett syndrome (a neurodevelopmental disorder) retain specific motor and memory skills , And delay the onset of this disease.
Relevant results were made by researchers from the Jan and Dan Duncan Institute of Neuroscience at Baylor College of Medicine and Texas Children's Hospital, and the results were published in the journal Nature.
The authors found that in the mouse model of Rett syndrome, intensive training before the onset of symptoms can significantly improve the performance of specific exercise and memory tasks, and greatly delay the onset of symptoms.
Relevant results were made by researchers from the Jan and Dan Duncan Institute of Neuroscience at Baylor College of Medicine and Texas Children's Hospital, and the results were published in the journal Nature.
The authors found that in the mouse model of Rett syndrome, intensive training before the onset of symptoms can significantly improve the performance of specific exercise and memory tasks, and greatly delay the onset of symptoms.
Researchers recommend genetic testing for newborns with Rett syndrome, and then rapid in-depth skills training, such as gait/balance, dexterity, and communication skills, so as to improve the condition and improve the quality of life, and for future treatment ready.
(Image source: www.
pixabay.
com)
pixabay.
com)
Corresponding author Dr.
Huda Zoghbi said: "A few years ago, we decided to study Rett syndrome because it is very different from other neurological diseases.
"
Huda Zoghbi said: "A few years ago, we decided to study Rett syndrome because it is very different from other neurological diseases.
"
Rett syndrome is a rare and destructive neurological disease that mainly occurs in girls.
It will cause varying degrees of intellectual and motor disability, and there is no effective treatment.
It will cause varying degrees of intellectual and motor disability, and there is no effective treatment.
In a 1999 report, the Zoghbi laboratory showed for the first time that a mutation in the X-linked gene MECP2 caused Rett syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Although there is currently no effective treatment for Rett syndrome, previous work in the Zoghbi laboratory has shown that deep brain stimulation (DBS) can correct certain symptoms in animal models, such as learning and memory disorders.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
The researchers followed the idea of imitating DBS, but adopted a less invasive method.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
(Image source: www.
pixabay.
com)
pixabay.
com)
Corresponding author Dr.
Huda Zoghbi said: "A few years ago, we decided to study Rett syndrome because it is very different from other neurological diseases.
"
Huda Zoghbi said: "A few years ago, we decided to study Rett syndrome because it is very different from other neurological diseases.
"
Rett syndrome is a rare and destructive neurological disease that mainly occurs in girls.
It will cause varying degrees of intellectual and motor disability, and there is no effective treatment.
It will cause varying degrees of intellectual and motor disability, and there is no effective treatment.
In a 1999 report, the Zoghbi laboratory showed for the first time that a mutation in the X-linked gene MECP2 caused Rett syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Although there is currently no effective treatment for Rett syndrome, previous work in the Zoghbi laboratory has shown that deep brain stimulation (DBS) can correct certain symptoms in animal models, such as learning and memory disorders.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
The researchers followed the idea of imitating DBS, but adopted a less invasive method.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Rett syndrome is a rare and destructive neurological disease that mainly occurs in girls.
It will cause varying degrees of intellectual and motor disability, and there is no effective treatment.
It will cause varying degrees of intellectual and motor disability, and there is no effective treatment.
In a 1999 report, the Zoghbi laboratory showed for the first time that a mutation in the X-linked gene MECP2 caused Rett syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Although there is currently no effective treatment for Rett syndrome, previous work in the Zoghbi laboratory has shown that deep brain stimulation (DBS) can correct certain symptoms in animal models, such as learning and memory disorders.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
The researchers followed the idea of imitating DBS, but adopted a less invasive method.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
In a 1999 report, the Zoghbi laboratory showed for the first time that a mutation in the X-linked gene MECP2 caused Rett syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Since then, the author is committed to continuing to deepen our understanding of this complex disease.
This recent study provides new hope for improving the lives of girls with this syndrome.
Although there is currently no effective treatment for Rett syndrome, previous work in the Zoghbi laboratory has shown that deep brain stimulation (DBS) can correct certain symptoms in animal models, such as learning and memory disorders.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
The researchers followed the idea of imitating DBS, but adopted a less invasive method.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Although there is currently no effective treatment for Rett syndrome, previous work in the Zoghbi laboratory has shown that deep brain stimulation (DBS) can correct certain symptoms in animal models, such as learning and memory disorders.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
However, each symptom requires specific DBS treatment, which means that it will be difficult to implement this method to treat the syndrome.
The researchers followed the idea of imitating DBS, but adopted a less invasive method.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
The researchers followed the idea of imitating DBS, but adopted a less invasive method.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers investigated whether early intensive training on specific tasks before symptoms appear would change the normal course of the disease.
Research on autism spectrum disorder (ASD), a disease with symptoms similar to Rett syndrome, has shown that behavioral training can improve the motor and cognitive abilities of children with ASD.
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
The researchers focused on the Rett mouse model.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
The female of this mouse lacks one of the two copies of the Mecp2 gene.
Researchers tested the effect of intensive training in motor coordination tasks on the progression of Rett syndrome.
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
"We found that early life is an important window in order to significantly improve the behavioral deficits of mice through intensive training.
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
Mice that started training a few weeks before the onset of symptoms greatly improved their performance on specific motor tasks.
Important However, we also learned that early training will greatly delay the onset of symptoms, and starting training after symptoms appear does not improve performance.
"
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
When the researchers provided early training on memory tasks, compared with untrained Rett mice, these mice showed improvements in these tasks, but showed no improvement in other areas.
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Early vigorous training also delayed the memory and learning difficulties of these mice.
"We also found that the root of this benefit is the repeated activation of task-specific neurons.
"
Experiments have shown that task-specific neurons that are repeatedly activated during the training process will form more dendritic dendrites or cell projections.
They form and maintain neuronal circuits, thereby enhancing their function and delaying the onset of symptoms.
In contrast, the task-specific neuron disease of untrained animals continues to deteriorate.
(Bioon.
com)
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Information source: com/news/2021-03-early-symptom-onset-mouse-rett.
html">Early training delays symptom onset in mouse model of Rett syndrome
Information source: com/news/2021-03-early-symptom-onset-mouse-rett. html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
html">Early training delays symptom onset in mouse model of Rett syndrome
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Original source: Nathan P.
Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
Original source: Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome Nature Achilly, Wei Wang & Huda Y.
Zoghbi.
Presymptomatic training mitigates functional deficits in a mouse model of Rett syndrome , Nature (2021).
DOI: 10.
1038/s41586-021-03369-7
