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Experts comment on Nat Chemistry | Zou Peng/Chen Peng cooperate to develop membrane potential probes in the far red region based on "bio-orthogonal engineering"
Time of Update: 2021-04-23
In this work, the two research groups collaborated to use the "inverse electron demand Diels-Alder reaction" to point and specifically label the "proton pump" membrane protein-rhodopsin on the surface of neurons, and then construct a A series of fluorescent membrane potential probes with high sensitivity and imaging signal-to-noise ratio can detect neuronal action potentials in the far red area.
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Sci Transl Med: Adrenergic system as a target to inhibit neuroinflammation after cerebral hemorrhage
Time of Update: 2021-04-23
found that bone marrow hematopoietic stem cells (HSCs) increased in cerebral hemorrhage patients and mouse models .
In mice, adrenergic innervation mediates the increase in hematopoietic function after cerebral hemorrhage, and newly generated cells infiltrate the brain to inhibit neuroinflammation and reduce brain damage.
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Muscle weakness stupidly confused? Experts from Huashan Gods Share Cheats
Time of Update: 2021-04-23
Figure 2: The general idea of the clinical diagnosis of muscle weakness.
For the diagnosis of muscle weakness, whether it is peripheral nerve or muscle disease, there is actually a phenomenon-the coexistence of multiple diagnoses.
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Science Advances | Wuhan University and other institutions cooperate!
Time of Update: 2021-04-23
On April 16, 2021, Keqiang Ye of Emory University and Zhaohui Zhang of Wuhan University jointly published a research paper entitled "Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies" in Science Advances.
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Killing "good guys" by mistake?
Time of Update: 2021-04-23
▲In the brains of Alzheimer's disease model mice, microglia (white) lacking TAM receptors were observed to surround dense nucleoprotein plaques (red) (picture source: reference [2]; Credit: Salk Institute) further used real-time imaging technology to track dense nuclear protein plaques, and the researchers found a result that surprised them: when microglia eats a loose-shaped plaque, it will eat the beta amyloid.
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Acta Neuropathologica Communications: Repeated mild traumatic brain injury causes behavioral defects and pathological changes.
Time of Update: 2021-04-22
Taking humans as an example, these findings indicate that if a person experiences rmTBIs, regardless of whether they are diagnosed with a concussion, the repetitive nature of the injury may trigger the pathological process and bring about long-term pathological and cognitive consequences .
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Eur Radiol: How to use differences in plaque characteristics and hemodynamics to predict the clinical prognosis of ischemic stroke?
Time of Update: 2021-04-22
Recently, a study published in the journal European Radiology explored the differences in middle cerebral artery (MCA) plaques and hemodynamic characteristics in patients with ischemic stroke and transient ischemic attack (TIA), and established the deficiency Predictive model of blood stroke and nerve damage.
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Stroke: The relationship between autonomic dysregulation and the risk of dementia and stroke
Time of Update: 2021-04-22
Researchers used the Cox regression model to assess the link between resting heart rate and heart rate variability and the risk of stroke and dementia, while adjusting for potential confounding factors and assessing their interaction with age and gender.
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JAHA: Effects of oral anticoagulation therapy and left atrial appendage occlusion on cognitive function and quality of life in patients with atrial fibrillation
Time of Update: 2021-04-22
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">heart blood vessels published a research article on the disease areas authoritative magazine JAHA, the researchers compared the cognitive status is still receiving oral anticoagulation (OAC) in patients with atrial fibrillation and left atrial appendage occlusion after receiving life (LAAO) or AF ablation quality.
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Neurology: Prevent dementia after stroke?
Time of Update: 2021-04-22
So, are general cognitive impairment and domain-specific cognitive impairment 6 months after stroke related to depression and anxiety?Whether it is PSD, CAD or PSCI, it not only affects the patient's quality of life, but also hinders the recovery of their neurological function.
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Nature sub-news: Don't rush to get rid of plaques! New research suggests that plaque in Alzheimer's disease may be protective
Time of Update: 2021-04-22
Researchers were able to experimentally prove for the first time that microglia with TAM receptors ingest amyloid plaques through eat-me signaling and Gas6.
Researchers were able to experimentally prove for the first time that microglia with TAM receptors ingest amyloid plaques through eat-me signaling and Gas6.
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Neurology: Preventing stroke?
Time of Update: 2021-04-22
Biomarkers including RBP-4, NT-proBNP and GFAP have a specificity of 100% for the diagnosis of ischemic stroke, and they have a certain sensitivity.
Biomarkers including RBP-4, NT-proBNP and GFAP have a specificity of 100% for the diagnosis of ischemic stroke, and they have a certain sensitivity.
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NeuroImage: Neural mechanism of anesthesia loss of consciousness and recovery of consciousness
Time of Update: 2021-04-22
(A) Left panel: the time history of the autocorrelation index of different networks at the population level; right panel: the two-tailed paired sample t test (df=17) was used to measure the LOR and ROR values of the 120-second data window before and after the state transition point.
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The first plant-derived cannabinoid new anti-epileptic drug!
Time of Update: 2021-04-22
Recently, the company announced that the European Commission (EC) has approved a Class II change application for Epidylex (cannabidiol, cannabidiol, CBD) oral liquid formulations as an adjuvant therapy for patients ≥ 2 years of age, treatment and outcome Seizures associated with Sexual Sclerosis Syndrome (TSC).
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Neurology: The evidence of "Meng's mother's three migrations" is here!
Time of Update: 2021-04-22
First of all, a study published on JAMA Network Open last year showed that compared with children from affluent communities, children from poor communities perform poorly in a range of cognitive functions such as language ability, reading skills, memory and attention.
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Alzheimer Dementia: Plasma P-tau181-Aβ42 ratio, which can efficiently screen for Alzheimer's disease
Time of Update: 2021-04-22
The important significance of this study is that the plasma P-tau181/Aβ42 ratio is non-invasive and can be used to identify AD patients with elevated brain amyloid in people with CeVD.
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JNNP: Can you walk independently after a stroke depends on those factors?
Time of Update: 2021-04-22
Factors priori definitions (priori) include participant demographics: age, gender, hand; before stroke: high blood pressure, ischemic heart disease, high cholesterol, hyperlipidemia, diabetes, atrial fibrillation; stroke-related: severe stroke The degree, stroke type, ischemic stroke location, stroke hemisphere, thrombolysis, and the correlation with independent walking were investigated by using the Cox proportional hazard model of specific cause competition risk.
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Eur Heart J: The link between sleep and wakefulness burden and long-term all-cause and cardiovascular mortality
Time of Update: 2021-04-22
1093/eurheartj/ehab151" target="_blank" rel="noopener">Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women .
1093/eurheartj/ehab151" target="_blank" rel="noopener">Sleep arousal burden is associated with long- term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women in this message
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JNNP: A systematic review and meta-analysis of the effects of craniocerebral injury on children's neurocognitive function
Time of Update: 2021-04-22
This article assumes that compared with the control group, at any point in time In one or more of the six defined cognitive domains, children with TBI of any severity (mild, moderate, or severe) have a worse prognosis.
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Autophagy: A new hope for the treatment of neuralgia: joint activation of autophagy and antioxidant response
Time of Update: 2021-04-22
In addition, after autophagy is inhibited or activated, neuroinflammation and reactive oxygen species (ROS) levels increase or decrease, respectively .
After autophagy inhibition or activation, neuroinflammation and reactive oxygen species (ROS) levels increase or decrease, respectively.
