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Traumatic brain injury (Traumatic brain injury, TBI) is defined as changes in brain function caused by external forces or other brain pathological evidence.
In order to understand the mild pathophysiology of human rmTBI, Xiaoyun Xu et al.
In this model, the mice received 5 mTBIs (once a day for 5 consecutive days), using the head rotation generated by the cortical impactor.
2 2 1/3 2 2
In a preliminary study using this mTBI model, it was found that a single silver staining of mTBI 1 week after mTBI did not show diffuse axonal damage to the corpus callosum of mice.
The severity of repetitive mild traumatic brain injury (rmTBIs) is not enough to reach the diagnostic threshold of concussion and will have long-term consequences.
Diagnose that rmTBI produces diffuse axonal injury, transient inflammatory response, and diffusion tensor imaging (DTI) changes, and subsides over time, rmTBI produces diffuse axonal injury, transient inflammatory response, and diffusion tensor imaging (DTI) changes, and Over time , changes in magnetic resonance spectroscopy (MRS), changes in synaptic protein levels, behavioral defects such as attention and spatial memory, accumulation of pathological phosphorylated tau, changes in blood metabolism, and white matter ultrastructural abnormalities, magnetic resonance spectroscopy (MRS) Changes in synaptic protein levels, behavioral defects such as attention and spatial memory, accumulation of pathological phosphorylated tau, changes in blood metabolism and abnormal white matter ultrastructure
However, the mild and transient inflammatory response triggered by the rmTBI model described herein tends to explain that rmTBI is indeed mild, but still triggers pathophysiological changes that change over time and last for several months .
rmTBI is indeed mild, but still triggers pathophysiological changes that change over time and last for several months.
biomedcentral.
biomedcentral.
com/articles/10.
1186/s40478-021-01161-2" target="_blank" rel="noopener">.
Xu Xiaoyun, Cowan Matthew, Beraldo Flavio et al Repetitive mild traumatic brain injury in mice triggers a slowly developing cascade of long-term and persistent behavioral deficits and pathological changes [J] .
Acta Neuropathol Commun, 2021, 9:.
60.
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