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Noninvasive neuroimaging studies in humans and primates have shown that anesthesia-induced unconsciousness is related to the extensive destruction of neural activity and large-scale brain network functional connections.
The purpose of the study was to compare the time course of functional magnetic resonance imaging-based neural activity in healthy volunteers before, during and after the use of propofol at a gradually adjusted target concentration.
The study used functional magnetic resonance imaging (fMRI) data obtained before, during, and after injection of propofol in healthy volunteers with target concentrations adjusted in increments.
Figure 1.
Figure 1.
Figure 2 Induction of brain activity-emergence, retardation and global changes.
Figure 2 Induction of brain activity-emergence, retardation and global changes.
Figure 3 Network changes of brain activity during state transition.
Figure 3 Network changes of brain activity during state transition.
Shown in Figure 4.
Shown in Figure 4.
Figure 5.
Figure 5.
In the process of unconsciousness, the local neural time scale of the entire brain gradually increases, while the distant functional connections gradually decrease.
The rapid increase in cortical nerve processing speed and the rapid activation of subcortical cortical functional connections may be the reason for the restart of consciousness after anesthesia.
Huang Z, Tarnal V, Vlisides PE, et al.
Huang Z, Tarnal V, Vlisides PE, et al.
Asymmetric neural dynamics characterize loss and recovery of consciousness [published online ahead of print, 2021 Apr 10].
Neuroimage .
2021;118042.
doi:10.
1016/j.
neuroimage.
2021.
118042 Huang Z , Tarnal V, Vlisides PE, et al.
Asymmetric neural dynamics characterize loss and recovery of consciousness [published online ahead of print, 2021 Apr 10].
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