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JAHA: The relationship between visceral adipose tissue and skeletal muscle density and stroke, myocardial infarction, and all-cause death
Time of Update: 2021-04-23
The researchers collected strokes, myocardial infarctions, and all-cause deaths through the National Registry, and used Cox regression to calculate the risk ratio (HR) and 95% CI for VAT not increasing by 1 SD and muscle density by 1 SD.
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JNNP: Inhomogeneous distribution of tau pathology in Alzheimer's disease behavioral variants
Time of Update: 2021-04-23
The pathological distribution of tau in the brains of Alzheimer's disease behavior variants (bvAD, shown separately) and Alzheimer's disease subjects (tAD, shown as the average of the group).
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Cell: Who said that pressure is motivation?
Time of Update: 2021-04-23
The study showed that stress-induced hormones (glucocorticoids) can weaken the anti-cancer ability of innate-like T cells, leading to accelerated development and spread of cancer cells.
However, this study by Cell Reports shows that congenital T cells do not actually die due to chronic stress, but their anti-cancer ability is greatly impaired by stress-induced hormones (glucocorticoids).
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Science contention | The core position of the biological clock "conductor" BMAL1 gene shakes?
Time of Update: 2021-04-23
This study found that Bmal1 knockout mice In the case of skin fibroblasts and liver slice tissues without any external driving factors (such as daily light or temperature cycles), their transcriptome, proteome and phosphorylated proteome can all show 24h oscillations, Bmal1 It does not seem to be a necessary regulator to control the body's circadian rhythm.
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Nat Commun: Depleting B cells can reverse the progression of Alzheimer's disease
Time of Update: 2021-04-23
Despite the expression of a transgene that promotes AD, the loss of B cells alone is sufficient to reduce the burden of Aβ plaques and disease-related microglia .
Loss of B cells alone is sufficient to reduce the burden of Aβ plaques and disease-related microglia.
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[Two breakthrough new studies] One is a new technology to reduce Alzheimer’s disease β-amyloid protein, and the other is a new link between the subgingival microflora imbalance and Alzheimer’s disease biomarkers
Time of Update: 2021-04-23
Recently, scientists published a paper entitled "Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer's disease mice" in the journal "Brain".
Coincidentally, recently, researchers at New York University discovered that the increase in "bad" bacteria in the gums and the decrease in "good" bacteria are related to the brain's beta-amyloid protein.
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China Voice|Is there a causal relationship between linoleic acid and ischemic stroke?
Time of Update: 2021-04-23
This study aims to evaluate whether there is a potential causal relationship between circulating linoleic acid (LA) levels and ischemic stroke (IS) through Mendelian randomization (MR).
The study concluded that there is a causal relationship between circulating LA level and IS risk, especially with aortic stroke.
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The peculiar case of always not getting enough food has unlocked a secret for scientists who developed weight-loss drugs
Time of Update: 2021-04-23
Scientists from the Weizmann Institute of Science in Israel, Queen Mary University of London, and Hebrew University of Jerusalem have collaborated to clarify a highly anticipated How innovative weight-loss drugs regulate the "hunger" switch in the brain, so as to control appetite and treat obesity.
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Lu Yuanqiang, Zhejiang University, etc.: Clinical analysis of eight cases of peripheral neuropathy caused by n-hexane poisoning
Time of Update: 2021-04-23
Content Introduction Chinese Abstract: Objective: To investigate the clinical features, diagnosis and treatment of peripheral neuropathy caused by subacute n-hexane poisoning.
JZUS-B welcomes outstanding scholars at home and abroad to contribute the latest scientific research results, controversial topics, review papers, and organize the publication of hot albums.
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Muscle weakness stupidly confused? I will teach you!
Time of Update: 2021-04-23
Figure 2: The general idea of the clinical diagnosis of muscle weakness.
For the diagnosis of muscle weakness, whether it is peripheral nerve or muscle disease, there is actually a phenomenon-the coexistence of multiple diagnoses.
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Nat Neurosci | Zhou Zikai/Ji Minjun's team proposes potential treatment strategies for immune abnormal autism
Time of Update: 2021-04-23
On April 15, 2021, Professor Zhou Zikai from the Shanghai Mental Health Center-Shanghai Institute of Materia Medica of the Chinese Academy of Sciences and Professor Ji Minjun from the State Key Laboratory of Reproductive Medicine of Nanjing Medical University and Professor Ji Minjun from the Department of Pathogenic Biology published a report on Nature Neuroscience Research paper Rescue of maternal immune activation-induced behavioral abnormalities in adult mouse offspring by pathogen-activated maternal Treg cells.
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Qiang Liu's research group Science Translational Medicine discovered a new function of the bone marrow hematopoietic system after brain injury-inhibiting neuroinflammation
Time of Update: 2021-04-23
On April 14, 2021, Professor Liu Qiang's team from the Department of Neurology, Tianjin Medical University General Hospital published a study titled "Brain injury instructs bone marrow cellular lineage to reduce neuroinflammation" in Science Translational Medicine.
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Express | A new generation of CD20 antibodies reached the primary endpoint of two phase 3 clinical trials, significantly reducing the annual recurrence rate of MS disease
Time of Update: 2021-04-23
▎The content team editor of WuXi AppTec today, TG Therapeutics announced that its innovative glycoengineered anti-CD20 antibody ublituximab has reached the primary endpoint in two phase 3 clinical trials, significantly reducing multiple sclerosis (MS) compared with the active control group The patient’s annual disease recurrence rate (ARR).
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Cell Death Differ︱ Song Xiaoyuan’s team reported on the molecular mechanism of long non-coding RNA Synage regulating synaptic structure and neuronal function in the cerebellum
Time of Update: 2021-04-23
On March 24, 2021, Professor Song Xiaoyuan’s research team from the School of Life Sciences of the University of Science and Technology of China published a research paper entitled The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum online in Cell Death & Differentiation, reporting lncRNA Synage regulates the molecular mechanism of synaptic structure and neuronal function in the cerebellum.
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Nat Immunol | Huang Youtong and others reveal the molecular mechanism of microglia recognition and response to β amyloid precipitation
Time of Update: 2021-04-23
Huang Youtong) published an article Microglia use TAM receptors to detect and engulf amyloid β plaques in Nature Immunology, revealing that Mer and Axl recognize and respond to microglia It plays an important role in the precipitation of Abeta amyloid associated with Alzheimer's disease.
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Science Sub-Journal: Stop working and rest upside down!
Time of Update: 2021-04-23
This study shows that in a mouse melanoma model, compared with the normal light-dark cycle (LD), the circadian rhythm disorder will lead to the loss or reversal of the levels of macrophages and cytokines in the liver and tumor tissues of the mice.
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Nature and Science jointly reveal the secret of hunger!
Time of Update: 2021-04-23
And now the results of the study clearly show that compared with the initial peak blood glucose response after eating, the drop in sugar is more predictive of hunger and subsequent calorie intake, which also changes our perception of blood sugar levels and foods eaten.
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Sub-Journal of "Nature": There are "zombie genes" in the brain. People die, but they live
Time of Update: 2021-04-23
Selective time-dependent changes in human brain activity and cell-specific gene expression after death Next, the researchers performed histological observations on brain tissue samples within 24 hours of brain death and discovered three types of genes.
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【Nature】Heavyweight | Scientists from New York University Discover New Tumor Suppressors, Becoming Potential Treatments
Time of Update: 2021-04-23
This article is converted Medicine original, reproduced please indicate the source Author: Yun Introduction: The recent study found that during embryonic development, a kind of enzyme protein on the cell cycle control for normal cell growth is essential, it The dysfunction can lead to fatal cell overgrowth.
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Knowing the article: the clinical classification of motor neuron disease
Time of Update: 2021-04-23
Except for amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), progressive bulbar palsy (PBP) and primary lateral sclerosis (PLS) ) In addition to the 4 main clinical types, there are also relatively rare special types such as flail arm/leg syndrome.
