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Everyone wants to see the prosperity of the world, but can't escape birth, old age, sickness and death.
The traditional view is that after death, the body will permanently stop working irreversibly, but the latest research has found that this is not the case.
Recently, researchers from the University of Illinois at Chicago (Salute Church) published an article in Scientific Reports entitled Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain.
This kind of "zombie gene", this gene is not only still active within a few hours after death, but its expression level has increased! https://doi.
org/10.
1038/s41598-021-85801-6 In order to verify that this magical phenomenon is not a fantasy, researchers used fresh human brain tissue collected during routine brain surgery to conduct a simulated death experiment.
First, the researchers compared the gene regulation differences of RNAseq at the transcript level in brain tissue before and after death, and found that the key gene "RBFOX1" in the brain tissue after death has greatly reduced splicing complexity, which shows that the important genes in brain tissue There is a significant difference in the complexity of transcription before and after death.
Selective time-dependent changes in human brain activity and cell-specific gene expression after death Next, the researchers performed histological observations on brain tissue samples within 24 hours of brain death and discovered three types of genes.
The first type of genes in HE staining of brain tissue samples are called "gene housekeepers", which account for about 80% of all analyzed gene types.
The expression of these genes in the brain remains relatively stable while maintaining the basic functions of cells.The second type of genes are mainly found in neurons and have a complex relationship with human brain activities (such as memory, thinking, and seizure activity).
Their expression activity will decline rapidly within a few hours after death.
The third type of genes are "zombie genes".
These genes are derived from glial cells that play an important role in the inflammation of the central nervous system.
After the death of humans, these cells will grow arm-like attachments, which are found in neurons.
When gene activity is weakened, agitation begins, and its activity reaches its peak 12 hours after brain death.
The "zombie gene" restores life after the death of the human brain.
Researchers said that this human brain test is of special significance for the development of new therapies for neurological diseases.
It is understood that autism, schizophrenia and Alzheimer's disease, etc.
Diseases are studied using human brain tissue after death.
Therefore, this new discovery can provide new ideas for finding potential treatments for such diseases.
End reference materials: [1]
The traditional view is that after death, the body will permanently stop working irreversibly, but the latest research has found that this is not the case.
Recently, researchers from the University of Illinois at Chicago (Salute Church) published an article in Scientific Reports entitled Selective time-dependent changes in activity and cell-specific gene expression in human postmortem brain.
This kind of "zombie gene", this gene is not only still active within a few hours after death, but its expression level has increased! https://doi.
org/10.
1038/s41598-021-85801-6 In order to verify that this magical phenomenon is not a fantasy, researchers used fresh human brain tissue collected during routine brain surgery to conduct a simulated death experiment.
First, the researchers compared the gene regulation differences of RNAseq at the transcript level in brain tissue before and after death, and found that the key gene "RBFOX1" in the brain tissue after death has greatly reduced splicing complexity, which shows that the important genes in brain tissue There is a significant difference in the complexity of transcription before and after death.
Selective time-dependent changes in human brain activity and cell-specific gene expression after death Next, the researchers performed histological observations on brain tissue samples within 24 hours of brain death and discovered three types of genes.
The first type of genes in HE staining of brain tissue samples are called "gene housekeepers", which account for about 80% of all analyzed gene types.
The expression of these genes in the brain remains relatively stable while maintaining the basic functions of cells.The second type of genes are mainly found in neurons and have a complex relationship with human brain activities (such as memory, thinking, and seizure activity).
Their expression activity will decline rapidly within a few hours after death.
The third type of genes are "zombie genes".
These genes are derived from glial cells that play an important role in the inflammation of the central nervous system.
After the death of humans, these cells will grow arm-like attachments, which are found in neurons.
When gene activity is weakened, agitation begins, and its activity reaches its peak 12 hours after brain death.
The "zombie gene" restores life after the death of the human brain.
Researchers said that this human brain test is of special significance for the development of new therapies for neurological diseases.
It is understood that autism, schizophrenia and Alzheimer's disease, etc.
Diseases are studied using human brain tissue after death.
Therefore, this new discovery can provide new ideas for finding potential treatments for such diseases.
End reference materials: [1]
